Oklahoma Rheumatic Disease Research Cores Center

俄克拉荷马州风湿病研究核心中心

• 批准号: 10704387
• 负责人: JUDITH A JAMES
• 金额: $ 85.25万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704387
• 关键词: Address; Aliquot; American; Applications Grants; Basic Science; Biological Markers; Caring; Cells; Certification; Clinical; Clinical Data; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Design; Cohort Studies; Collaborations; Collection; Communication; Complex; Cytometry; Data; Development; Diagnosis; Disease; Distant; Educational workshop; Electronics; Enrollment; Evaluation; Fostering; Funding; Genetic; Goals; Health; Heterogeneity; Human; Human Resources; Immunologic Monitoring; Immunologics; Individual; Information Systems; Infrastructure; Institution; Institutional Review Boards; Investigation; Investments; Leadership; Lupus; Manuscripts; Mediator; Mentors; Mission; Molecular; Monitor; Morbidity - disease rate; National Institute of Allergy and Infectious Disease; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Oklahoma; Participant; Pathogenesis; Pathologic; Pathologist; Patient Selection; Patient-Focused Outcomes; Patients; Phenotype; Pilot Projects; Precision therapeutics; Preparation; Prevention; Procedures; Process; Prognosis; Program Development; Proteomics; Protocols documentation; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Rheumatism; Sampling; Scholars Program; Science; Scientist; Seasons; Selection for Treatments; Services; Symptoms; Technology; Testing; Training; Training Programs; Underrepresented Populations; Underserved Population; Visit; Work; Writing; assay development; base; biobank; career; career development; clinical phenotype; cohort; college; data warehouse; disease classification; empowerment; experience; forging; high dimensionality; improved; innovation; inter-institutional; investigator-initiated trial; molecular phenotype; mortality; multidimensional data; multidisciplinary; multiple omics; next generation; novel; outreach; patient subsets; phenotypic data; precision medicine; programs; recruit; sample collection; skills; success; systems research; technology platform; transcriptomics; web-enabled; young woman

Oklahoma Rheumatic Disease Research Cores Center: Overall The mission of the Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) is to support and optimize interactions between basic, clinical, and analytical scientists focused on the pathogenesis, prediction, prevention, and precision therapeutic selection for rheumatic diseases. Towards this aim, the ORDRCC integrates 26 established center investigators, 22 junior center investigators (12 within and 10 outside Oklahoma), and 12 potential scholars to develop early-stage investigators with outstanding promise in rheumatic disease research. The ORDRCC infrastructure, collections, Cores and Enrichment Program have helped successfully launch the independent careers of 33 former New Investigators. In addition, our CAP- certified Biorepository within the Clinical Characterization and Biorepository Core (CCBC) provides access to well-phenotyped cross-sectional and longitudinal rheumatic disease sample collections. The ORDRCC- supported collections and biorepository infrastructure are critical resources for many established rheumatic disease investigators from within the ORDRCC and through inter-institutional rheumatic disease collaborations and clinical trials. In the past 4 years, the CCBC personnel have assisted with 151 IRB study protocols, recruitment of 1,282 participants, performed 2,648 cohort study visits and collected/processed 66,068 new sample aliquots, as well as fulfilled 571 samples or data requests. The CCBC will continue to expand these collections while providing clinical research units for study recruitment and regulatory assistance. Furthermore, the CCBC will develop an Innovation Hub to pilot novel clinical research approaches and a clinical trialist development program. The Human Phenotyping Core (HPC) provides experienced technical personal, standard operating procedures, training, and analytical expertise to empower ORDRCC investigators to use cutting-edge technologies, including high-dimensional cytometry, single-cell multi-omics, transcriptomics, spatial multi-omics, and high-throughput testing of soluble mediators. Together, the CCBC and HPC transform rheumatic disease investigation and clinical trials by integrating clinical and molecular information to identify molecularly homogeneous subsets of subjects for use in innovative study design. The Administrative Core serves as the central management and communication hub for the ORDRCC and co-ordinates a multi- disciplinary Enrichment Program, including a new rheumatic disease pipeline development program for underrepresented groups, a mentoring program, a new Science Writing Success Center to assist investigators with developing robust manuscripts and competitive grant applications, and Expanding Rheumatic Disease Research Colloquiums to increase outreach and forge interactions between ORDRCC scientists and other NIAMS Centers. Together, the ORDRCC facilitates and expands collaborative rheumatic disease research by providing career development, cutting-edge technologies, well-phenotyped clinical data, and fostering collaborations to improve patients’ lives.

俄克拉荷马州风湿性疾病研究核心中心：总体 俄克拉荷马州风湿病核心研究中心（ordrcc）的使命是支持和 优化基础，临床和分析科学家之间的互动，重点是发病机制，预测， 预防和精确治疗选择风湿性疾病。为了实现这一目标， 整合了26名已建立的中心研究者、22名初级中心研究者（12名内部研究者和10名外部研究者 俄克拉荷马州），和12名潜在的学者，以发展早期阶段的调查与杰出的承诺， 风湿病研究。该中心的基础设施、藏品、核心和浓缩计划， 帮助33名前新调查员成功开展独立职业生涯。此外，我们的CAP- 临床表征和生物储存库核心（CCBC）内的认证生物储存库提供了访问 良好表型的横截面和纵向风湿性疾病样本收集。该委员会- 支持的收集和生物储存基础设施是许多已建立的风湿性关节炎的关键资源， 疾病研究者从内部的ordrcc和通过机构间的风湿性疾病合作 和临床试验。在过去的4年里，CCBC人员协助了151项IRB研究方案， 招募了1，282名参与者，进行了2，648次队列研究访视，收集/处理了66，068名新的 样本等分试样，以及满足571个样本或数据请求。CCBC将继续扩大这些 收集，同时为临床研究单位提供研究招募和监管协助。此外，委员会认为， CCBC将建立一个创新中心，以试点新的临床研究方法和临床试验 发展计划。人类表型核心（HPC）提供经验丰富的技术人员， 标准操作程序、培训和分析专业知识，使ORDCC调查人员能够使用 尖端技术，包括高维细胞计数，单细胞多组学，转录组学， 空间多组学和可溶性介质的高通量测试。CCBC和HPC共同实现了 风湿性疾病的调查和临床试验，通过整合临床和分子信息， 用于创新研究设计的受试者的分子同质子集。行政核心 作为该协调中心的中央管理和通讯枢纽，并协调多个 学科丰富计划，包括一个新的风湿性疾病管道开发计划， 代表性不足的群体，辅导计划，一个新的科学写作成功中心，以协助调查人员 开发强大的手稿和有竞争力的赠款申请，并扩大风湿性疾病 研究座谈会，以增加外联和建立ORDRC科学家和其他 NIAMS中心。通过以下方式，ORDRCC共同促进和扩大了风湿性疾病的合作研究 提供职业发展，尖端技术，良好的表型临床数据， 合作改善患者的生活。

项目成果

Nucleic Acid-Sensing and Interferon-Inducible Pathways Show Differential Methylation in MZ Twins Discordant for Lupus and Overexpression in Independent Lupus Samples: Implications for Pathogenic Mechanism and Drug Targeting.

• DOI: 10.3390/genes12121898
• 发表时间: 2021-11-26
• 期刊: Genes
• 影响因子: 3.5
• 作者: Marion MC;Ramos PS;Bachali P;Labonte AC;Zimmerman KD;Ainsworth HC;Heuer SE;Robl RD;Catalina MD;Kelly JA;Howard TD;Lipsky PE;Grammer AC;Langefeld CD
• 通讯作者: Langefeld CD