Oklahoma Rheumatic Disease Research Cores Center

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Oklahoma Rheumatic Disease Research Cores Center: Overall The mission of the Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) is to support and optimize interactions between basic, clinical, and analytical scientists focused on the pathogenesis, prediction, prevention, and precision therapeutic selection for rheumatic diseases. Towards this aim, the ORDRCC integrates 26 established center investigators, 22 junior center investigators (12 within and 10 outside Oklahoma), and 12 potential scholars to develop early-stage investigators with outstanding promise in rheumatic disease research. The ORDRCC infrastructure, collections, Cores and Enrichment Program have helped successfully launch the independent careers of 33 former New Investigators. In addition, our CAP- certified Biorepository within the Clinical Characterization and Biorepository Core (CCBC) provides access to well-phenotyped cross-sectional and longitudinal rheumatic disease sample collections. The ORDRCC- supported collections and biorepository infrastructure are critical resources for many established rheumatic disease investigators from within the ORDRCC and through inter-institutional rheumatic disease collaborations and clinical trials. In the past 4 years, the CCBC personnel have assisted with 151 IRB study protocols, recruitment of 1,282 participants, performed 2,648 cohort study visits and collected/processed 66,068 new sample aliquots, as well as fulfilled 571 samples or data requests. The CCBC will continue to expand these collections while providing clinical research units for study recruitment and regulatory assistance. Furthermore, the CCBC will develop an Innovation Hub to pilot novel clinical research approaches and a clinical trialist development program. The Human Phenotyping Core (HPC) provides experienced technical personal, standard operating procedures, training, and analytical expertise to empower ORDRCC investigators to use cutting-edge technologies, including high-dimensional cytometry, single-cell multi-omics, transcriptomics, spatial multi-omics, and high-throughput testing of soluble mediators. Together, the CCBC and HPC transform rheumatic disease investigation and clinical trials by integrating clinical and molecular information to identify molecularly homogeneous subsets of subjects for use in innovative study design. The Administrative Core serves as the central management and communication hub for the ORDRCC and co-ordinates a multi- disciplinary Enrichment Program, including a new rheumatic disease pipeline development program for underrepresented groups, a mentoring program, a new Science Writing Success Center to assist investigators with developing robust manuscripts and competitive grant applications, and Expanding Rheumatic Disease Research Colloquiums to increase outreach and forge interactions between ORDRCC scientists and other NIAMS Centers. Together, the ORDRCC facilitates and expands collaborative rheumatic disease research by providing career development, cutting-edge technologies, well-phenotyped clinical data, and fostering collaborations to improve patients’ lives.