Applied Physiology and Mechanisms

应用生理学和机制

• 批准号: 10293642
• 负责人: ALICE S. RYAN
• 金额: $ 16.72万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10293642
• 关键词: Acute; Aerobic; Aging; Alzheimer' s disease related dementia; American; Animal Model; Arthritis; Atrial Fibrillation; Basic Science; Biochemical; Biological Assay; Blood; Body Composition; COVID-19; Capsicum; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular system; Chronic; Chronic Disease; Clinical; Clinical Research; Congestive Heart Failure; Consultations; Development; Diabetes Mellitus; Disabled Persons; Disease; Elderly; Eligibility Determination; Endocrine; Ensure; Event; Evidence based intervention; Exercise; Faculty; Funding; Goals; Grant; HIV; Hip Fractures; Home; Human; In Vitro; Individual; Inflammation; Intensive Care Units; Interdisciplinary Study; Intervention; Knowledge; Link; Maryland; Measures; Medical; Mentors; Metabolic dysfunction; Methodology; Mission; Modeling; Molecular; Muscle; Musculoskeletal; Obesity; Older Population; Osteoporosis; Outcome; Outcome Measure; Paper; Participant; Patients; Performance; Peripheral arterial disease; Phenotype; Physical activity; Physiological; Physiology; Pilot Projects; Prevention; Property; Protocols documentation; Publications; Quality of life; Recovery; Rehabilitation therapy; Research; Research Design; Research Personnel; Research Support; Resistance; Resources; Rodent Model; Services; Severities; Stroke; System; Testing; Tissues; Training; Translating; Translational Research; Traumatic Brain Injury; United States National Institutes of Health; Universities; Work; age related; animal tissue; base; burden of illness; cardiometabolism; cardiovascular fitness; clinical center; clinical outcome measures; clinical translation; clinically relevant; clinically translatable; community setting; comorbidity; deconditioning; disability; disability risk; disabling disease; disorder risk; economic impact; exercise rehabilitation; exercise training; falls; functional decline; functional disability; functional independence; functional restoration; human tissue; improved; in vivo; innovation; laboratory experience; metabolic phenotype; mode of exercise; multidisciplinary; multimodality; neuromuscular; novel; patient safety; pre-clinical; prevent; rehabilitation strategy; research and development; restoration; sarcopenia; screening; socioeconomics; ward

Project Summary: RC-2 Age-related functional decline is accelerated by acute events by disabling conditions (e.g., stroke, hip fracture, arthritis, peripheral arterial disease) and chronic disease (e.g., cardiovascular disease, diabetes). These conditions predispose a multi-system decline that severely reduces functional independence and quality of life. The overarching goal of the UM-OAIC is to accelerate the development of meaningful interventions to improve disability related functional declines in older individuals. Evidence from studies by UM-OAIC investigators and others has linked the benefits of exercise to a reduction in the inflammation and endocrine- metabolic dysfunction that accompany disabling conditions in the older adults. These works inform our overarching hypothesis that exercise, activity-based, and multi-modal rehabilitation can improve multiple physiological systems in older mobility-limited individuals which in turn can improve functional performance, reduce cardiometabolic disease risk, and prevent functional decline. In this renewal, the RC-2 expands its clinical outcome measures and extends its support to parallel outcome measures in pre-clinical rodent models. RC-2 will be led by a multi-disciplinary team made up of Drs. Ryan, Katzel and Ward. Specific Aim 1 is to advance research focused on the mechanisms of functional decline in older persons with disability and the mitigation of decline with exercise or activity-based or multi-modal rehabilitation strategies. Specific Aim 2 is to provide mentoring and training to REC Scholars, affiliated faculty, and UM-OAIC researchers in the performance of aging research relevant to exercise and rehabilitation-based restoration of function and the prevention of functional declines in older people with chronic disabling diseases. Through RC-2’s support of REC Scholars, pilot projects, development projects, and external projects, we will advance the UM-OAIC mission to reduce disability and restore function in older individuals with disabling conditions and translate our discoveries toward impactful evidence-based interventions.

项目概要：RC-2 致残性疾病的急性事件加速了与糖尿病相关的功能下降（例如，髋关节中风 骨折、关节炎、外周动脉疾病）和慢性疾病（例如，心血管疾病、糖尿病）。 这些条件使多系统衰退，严重降低功能独立性和质量 生命UM-OAIC的总体目标是加快制定有意义的干预措施， 改善老年人与残疾相关的功能下降。来自UM-OAIC研究的证据 研究人员和其他人将运动的好处与炎症和内分泌的减少联系起来， 代谢功能障碍伴随着老年人的残疾状况。这些作品告诉我们， 总体假设，运动，活动为基础的，多模式的康复可以改善多种 生理系统在老年活动受限的个人，这反过来又可以提高功能性能， 降低心脏代谢疾病风险，预防功能衰退。在这次更新中，RC-2扩展了其 临床结果测量，并将其支持扩展到临床前啮齿动物模型中的平行结果测量。 RC-2将由一个多学科小组领导，该小组由Ryan博士、Katzel博士和Ward博士组成。具体目标1是 高级研究侧重于残疾老年人功能衰退的机制， 通过运动或基于活动或多模式康复策略缓解衰退。具体目标二是 为REC学者，附属教师和UM-OAIC研究人员提供指导和培训， 与基于运动和康复的功能恢复相关的衰老研究的表现， 预防患有慢性致残性疾病的老年人的功能衰退。通过RC-2的支持， REC学者，试点项目，发展项目和外部项目，我们将推进UM-OAIC 使命是减少残疾和恢复功能的老年人与残疾条件，并翻译我们的 发现有影响力的循证干预措施。