Applied Physiology and Mechanisms

项目概要：RC-2 致残性疾病的急性事件加速了与糖尿病相关的功能下降（例如，髋关节中风 骨折、关节炎、外周动脉疾病）和慢性疾病（例如，心血管疾病、糖尿病）。 这些条件使多系统衰退，严重降低功能独立性和质量 生命UM-OAIC的总体目标是加快制定有意义的干预措施， 改善老年人与残疾相关的功能下降。来自UM-OAIC研究的证据 研究人员和其他人已经将运动的好处与炎症和内分泌的减少联系起来， 代谢功能障碍伴随着老年人的残疾状况。这些作品告诉我们， 总体假设，运动，活动为基础的，多模式的康复可以改善多种 生理系统在老年活动受限的个人，这反过来又可以提高功能性能， 降低心脏代谢疾病风险，预防功能衰退。在这次更新中，RC-2扩展了其 临床结果测量，并将其支持扩展到临床前啮齿动物模型中的平行结果测量。 RC-2将由一个多学科小组领导，该小组由Ryan博士、Katzel博士和Ward博士组成。具体目标1是 高级研究侧重于残疾老年人功能衰退的机制， 通过运动或基于活动或多模式康复策略缓解衰退。具体目标二是 为REC学者，附属教师和UM-OAIC研究人员提供指导和培训， 与基于运动和康复的功能恢复相关的衰老研究的表现， 预防患有慢性致残性疾病的老年人的功能衰退。通过RC-2的支持， REC学者，试点项目，发展项目和外部项目，我们将推进UM-OAIC 使命是减少残疾和恢复功能的老年人与残疾条件，并翻译我们的 发现有影响力的循证干预措施。

Project Summary: RC-2 Age-related functional decline is accelerated by acute events by disabling conditions (e.g., stroke, hip fracture, arthritis, peripheral arterial disease) and chronic disease (e.g., cardiovascular disease, diabetes). These conditions predispose a multi-system decline that severely reduces functional independence and quality of life. The overarching goal of the UM-OAIC is to accelerate the development of meaningful interventions to improve disability related functional declines in older individuals. Evidence from studies by UM-OAIC investigators and others has linked the benefits of exercise to a reduction in the inflammation and endocrine- metabolic dysfunction that accompany disabling conditions in the older adults. These works inform our overarching hypothesis that exercise, activity-based, and multi-modal rehabilitation can improve multiple physiological systems in older mobility-limited individuals which in turn can improve functional performance, reduce cardiometabolic disease risk, and prevent functional decline. In this renewal, the RC-2 expands its clinical outcome measures and extends its support to parallel outcome measures in pre-clinical rodent models. RC-2 will be led by a multi-disciplinary team made up of Drs. Ryan, Katzel and Ward. Specific Aim 1 is to advance research focused on the mechanisms of functional decline in older persons with disability and the mitigation of decline with exercise or activity-based or multi-modal rehabilitation strategies. Specific Aim 2 is to provide mentoring and training to REC Scholars, affiliated faculty, and UM-OAIC researchers in the performance of aging research relevant to exercise and rehabilitation-based restoration of function and the prevention of functional declines in older people with chronic disabling diseases. Through RC-2’s support of REC Scholars, pilot projects, development projects, and external projects, we will advance the UM-OAIC mission to reduce disability and restore function in older individuals with disabling conditions and translate our discoveries toward impactful evidence-based interventions.