Applied Physiology and Mechanisms

应用生理学和机制

基本信息

批准号：
10670298
负责人：
ALICE S. RYAN
金额：
$ 20.65万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670298
关键词：
Acceleration Acute Aerobic Aging Alzheimer&apos s disease related dementia American Animal Model Arthritis Atrial Fibrillation Basic Science Biochemical Biological Assay Blood Body Composition COVID-19 Capsicum Cardiometabolic Disease Cardiovascular Diseases Cardiovascular system Chronic Chronic Disease Clinical Clinical Research Congestive Heart Failure Development Diabetes Mellitus Disabled Persons Disease Elderly Eligibility Determination Endocrine Ensure Event Evidence based intervention Exercise Faculty Funding Goals Grant HIV Hip Fractures Home Human In Vitro Individual Inflammation Intensive Care Units Interdisciplinary Education Interdisciplinary Study Intervention Knowledge Link Malignant Neoplasms Maryland Measures Medical Mentors Metabolic dysfunction Methodology Mission Modeling Molecular Muscle Musculoskeletal Obesity Older Population Osteoporosis Outcome Outcome Measure Paper Participant Patients Performance Peripheral arterial disease Phenotype Physical activity Physiological Physiology Pilot Projects Prevention Property Protocols documentation Publications Quality of life Recovery Rehabilitation therapy Research Research Design Research Personnel Research Support Resistance Resources Rodent Model Services Severities Stroke System Testing Tissues Training Translating Translational Research Traumatic Brain Injury United States National Institutes of Health Universities Work age related animal tissue burden of illness cardiometabolism cardiovascular fitness clinical center clinical outcome measures clinical translation clinically relevant community setting comorbidity deconditioning disability disability risk disabling disease disorder risk economic impact exercise training falls functional decline functional disability functional independence functional restoration human tissue improved in vivo innovation laboratory experience metabolic phenotype mode of exercise multidisciplinary multimodality neuromuscular novel patient safety pre-clinical prevent rehabilitation strategy restoration sarcopenia screening socioeconomics ward

项目摘要

Project Summary: RC-2 Age-related functional decline is accelerated by acute events by disabling conditions (e.g., stroke, hip fracture, arthritis, peripheral arterial disease) and chronic disease (e.g., cardiovascular disease, diabetes). These conditions predispose a multi-system decline that severely reduces functional independence and quality of life. The overarching goal of the UM-OAIC is to accelerate the development of meaningful interventions to improve disability related functional declines in older individuals. Evidence from studies by UM-OAIC investigators and others has linked the benefits of exercise to a reduction in the inflammation and endocrine- metabolic dysfunction that accompany disabling conditions in the older adults. These works inform our overarching hypothesis that exercise, activity-based, and multi-modal rehabilitation can improve multiple physiological systems in older mobility-limited individuals which in turn can improve functional performance, reduce cardiometabolic disease risk, and prevent functional decline. In this renewal, the RC-2 expands its clinical outcome measures and extends its support to parallel outcome measures in pre-clinical rodent models. RC-2 will be led by a multi-disciplinary team made up of Drs. Ryan, Katzel and Ward. Specific Aim 1 is to advance research focused on the mechanisms of functional decline in older persons with disability and the mitigation of decline with exercise or activity-based or multi-modal rehabilitation strategies. Specific Aim 2 is to provide mentoring and training to REC Scholars, affiliated faculty, and UM-OAIC researchers in the performance of aging research relevant to exercise and rehabilitation-based restoration of function and the prevention of functional declines in older people with chronic disabling diseases. Through RC-2’s support of REC Scholars, pilot projects, development projects, and external projects, we will advance the UM-OAIC mission to reduce disability and restore function in older individuals with disabling conditions and translate our discoveries toward impactful evidence-based interventions.

项目摘要：RC-2 与年龄相关的功能下降通过禁用条件（例如中风，臀部）加速了急性事件骨折，关节炎，周围动脉疾病）和慢性疾病（例如心血管疾病，糖尿病）。这些条件易于多系统下降，从而严重降低了功能独立性和质量生活。 UM-OAIC的总体目标是加速有意义的干预措施改善老年人与残疾相关的功能下降。 UM-OAIC研究的证据调查人员和其他人将运动的好处与减少炎症和内分泌之间的益处联系在一起 - 适应老年人残疾条件的代谢功能障碍。这些作品告诉我们总体假设，即运动，基于活动和多模式康复可以改善多重较旧的移动性限制个人的物理系统又可以提高功能性能，降低心脏代谢疾病的风险，并防止功能下降。在此续约中，RC-2扩展了临床结果度量并将其支持扩展到临床前啮齿动物模型中的平行结局指标。 RC-2将由由DRS组成的多学科团队领导。瑞安（Ryan），卡兹尔（Katzel）和沃德（Ward）。具体目标1是预先研究的重点是残疾老年人功能下降的机制和通过锻炼或基于活动或多模式康复策略来缓解下降。具体目标2是为REC学者，会员教师和UM-OAIC研究人员提供心理和培训与基于运动和康复的功能恢复有关的衰老研究的表现预防慢性残疾疾病的老年人的功能下降。通过RC-2的支持 REC学者，试点项目，开发项目和外部项目，我们将推进UM-OAIC 在患有残疾状况的老年人中减少残疾和恢复功能的使命并将我们的转化发现有影响力的基于证据的干预措施。