Applied Physiology and Tissue Mechanisms

应用生理学和组织机制

• 批准号: 9545631
• 负责人: ALICE S. RYAN
• 金额: $ 22.7万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9545631
• 关键词: Acute; Adipose tissue; Aerobic; Aging; American; Biological Assay; Biomedical Research; Capsicum; Cardiovascular Deconditioning; Cardiovascular system; Chronic; Chronic Disease; Chronic Kidney Failure; Clinical; Clinical Trials; Collaborations; Communities; Consultations; Development; Elderly; Eligibility Determination; Endocrine; Ensure; Event; Exercise; Exercise stress test; Faculty; Functional disorder; Funding; Gene Expression; Grant; HIV-1; Hip Fractures; Impairment; Individual; Inflammation; Insulin Resistance; Intervention; Leadership; Maryland; Medical; Mentors; Metabolic; Metabolic dysfunction; Metabolic syndrome; Metabolism; Methodology; Modality; Molecular; Muscle; Musculoskeletal; Obesity; Outcome; Paper; Parkinson Disease; Patient Recruitments; Performance; Peripheral arterial disease; Physical Function; Physiological; Physiology; Pilot Projects; Population; Prevention; Prevention strategy; Preventive; Protocols documentation; Publications; Rehabilitation therapy; Research; Research Personnel; Research Support; Resistance; Resources; Risk; Scientist; Skeletal Muscle; Standardization; Stroke; System; Testing; Tissues; Training; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Vascular Endothelium; Work; base; bench to bedside; cardiometabolic risk; cardiometabolism; cardiovascular disorder risk; cardiovascular fitness; clinical phenotype; design; diabetes risk; disability; disabling disease; disorder risk; exercise intervention; exercise rehabilitation; exercise training; falls; fitness; functional decline; improved; innovation; laboratory experience; metabolic phenotype; mode of exercise; multidisciplinary; muscular structure; novel; patient safety; programs; protein expression; rehabilitation science; rehabilitation strategy; research and development; research study; response; restoration; sarcopenia; screening; volunteer; working group

7. Project Summary- Resource Core 2 Cardiovascular deconditioning, chronic inflammation, and endocrine-metabolic dysfunction are inherent to the pathophysiology of the physical impairments in older persons hindered by disabling chronic diseases of aging. Sarcopenia, poor fitness, inflammation, and acute events causing disability -- such as falls, stroke, and hip fracture -- occur with advancing age and may worsen mobility and increase risk for cardiovascular disease (CVD) and metabolic abnormalities. The Applied Physiology and Tissue Mechanisms Resource Core’s (RC-2) hypothesis is that exercise and activity-based rehabilitation can improve multiple physiological systems in older, mobility-limited individuals, leading to improved functional performance, reduced cardiometabolic disease risk, and prevention of functional decline. This core focuses on the following specific aims: 1)To facilitate the conduct of musculoskeletal and tissue mechanistic exercise rehabilitation and preventive biomedical research in aging and disability across the UM-OAIC pilot projects, UM-OAIC scholars’ research, Development Projects (DPs), and external NIH and VA funded research; and 2)To provide research support, mentoring, and training to UM-OAIC scholars, junior faculty, and UM-OAIC researchers in the performance of aging research relevant to exercise and rehabilitation-based restoration of function and the prevention of functional declines in older people with chronic disabling diseases. RC-2 leadership and investigators represent a multidisciplinary team of basic scientists with clinical geriatricians who have worked together for 15-20 years. The characterization of the clinical and metabolic phenotype(s) of individuals with stroke, hip fracture, and other chronic disabling diseases in RC-2 have allowed UM-OAIC investigators to develop successful specific exercise rehabilitation strategies to improve functional and clinical outcomes. Thus this core, in collaboration with the other UM-OAIC cores, will continue to support innovative research studies examining the mechanisms and physiological effects of multisystem rehabilitation and preventive strategies on functional and physiological outcomes in older adults aging with chronic disabilities, with translation of these outcomes in novel clinical trials.

7.项目摘要--资源核心2 心血管去条件性疾病、慢性炎症和内分泌-代谢功能障碍是 老年人身体损伤的病理生理学，因慢性老年病致残而受阻。 骨质疏松症、健康状况不佳、炎症和导致残疾的急性事件--如跌倒、中风和髋关节 骨折--随着年龄的增长而发生，可能会使行动不便，增加患心血管疾病的风险 (CVD)和代谢异常。应用生理学与组织机制资源库(RC-2) 假设运动和以活动为基础的康复可以改善多个生理系统 老年人，行动受限，导致功能表现改善，心脏代谢减少 疾病风险，防止功能衰退。这一核心侧重于以下具体目标：1) 促进进行肌肉骨骼和组织机械运动的康复和预防 UM-OAIC试点项目中关于老龄化和残疾的生物医学研究，UM-OAIC学者的研究， 开发项目(DP)，以及由国家卫生研究院和退伍军人事务部资助的外部研究；以及2)提供研究支持， 指导和培训UM-OAIC学者、初级教员和UM-OAIC研究人员 与运动和康复相关的衰老研究--基于功能的恢复和预防 患有慢性致残疾病的老年人的功能衰退。 RC-2领导层和研究人员代表了一个由基础科学家和临床研究人员组成的多学科团队 在一起工作了15-20年的老年医生。临床和代谢的特征 中风、髋部骨折和其他慢性致残性疾病患者的表型(S)在RC-2中允许 UM-OAIC调查人员开发成功的特定运动康复策略以改善功能 和临床结果。因此，该核心将与UM-OAIC的其他核心协作，继续支持 探索多系统康复机制和生理效应的创新性研究 老年慢性衰老患者的功能和生理结局及预防策略 残疾，并在新的临床试验中翻译这些结果。