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Early joint cranial and brain development from fetal and pediatric imaging

胎儿和儿科成像的早期关节颅骨和大脑发育

基本信息

批准号：
10299359
负责人：
Natasha Lepore
金额：
$ 78.61万
依托单位：
CHILDREN'S HOSPITAL OF LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10299359
关键词：
3-Dimensional Accounting Address Affect Age Ants Arizona Birth Bone Development Brain Brodmann&apos s area Cephalic Child Childhood Clinical Clinical Management Cognition Colorado Craniosynostosis Data Data Set Databases Deformity Development Diagnosis Diffusion Disease Evolution Face Fetal Development Fetal Growth Fetus Funding Future Goals Growth Head Health Hospitals Image Imaging Device Imaging Techniques Impaired cognition Individual Infant Institution Intracranial Hypertension Joints Knowledge Live Birth Logistic Regressions Los Angeles Magnetic Resonance Imaging Manuals Measures Methodology Methods Modeling Morphology Motion Motor Multiple Pregnancy National Institute of Child Health and Human Development National Institute of Dental and Craniofacial Research Neurologic Organ Patients Pediatric Hospitals Physicians Positioning Attribute Pregnancy Research Research Personnel Resources Sampling Shapes Standardization Surgical sutures Syndrome System Testing Thick Time Universities Variant Work X-Ray Computed Tomography aged automated segmentation base bone brain abnormalities brain morphology brain shape brain tissue brain volume cortex mapping cranium design developmental disease disability early childhood fetal graphical user interface imaging modality improved improved outcome in utero in vivo indexing model development morphometry multidisciplinary programs quantitative imaging sex success tool treatment planning user-friendly

项目摘要

PROJECT SUMMARY The devastating impacts of early-childhood cranial and skull deformities affect nearly 25% of infants from single pregnancies and 50% of those from multiple pregnancies. If not diagnosed early and treated effectively, these abnormalities can impact brain development, leading to cognitive impairment, elevated intracranial pressure, and motor disabilities. Clinicians’ capacity to effectively diagnose and treat these disorders is hindered by two things: first, a limited understanding of how the cranium and brain normally grow and co- develop; and, second, a dearth of imaging techniques that are sensitive enough to analyze joint cranial and brain development in both healthy and abnormal instances. To address these limitations, a strong, interdisciplinary, collaborative team from Children’s National Hospital, Children’s Hospital Los Angeles, Brown University, University of Colorado and Arizona State University proposes the current R01 aimed at developing the first normative joint model of brain and cranium development before and after birth. This work is f ueled by the team’s robust prior efforts, in which they independently collected large, normative datasets of computed tomography (CT) and magnetic resonance (MR) images of infants and fetuses, and implemented preliminary tools to analyze them as a starting point for new methods to be developed as part of this project . The team’s hypothesis is that the development of regional cortical and cranial morphologies will be strongly associated. It will be tested using the following aims: (1) Develop quantitative imaging tools to model healthy cranial development in infants; (2) Determine the joint development of cranial and cortical shape and thickness in infants; (3) Develop a preliminary model of fetal brain and cranial growth across gestation; and (4) Build and disseminate a user-friendly toolbox for clinicians and researchers. This project will be the ﬁrst systematic in-vivo study of joint healthy cranial and brain development before and after birth. As such, it will determine typical variations of the cranial shape and their correlations with brain parameters, adjusted for age and sex. The normative models generated here will serve as clinical resources for matched comparisons in individual children with suspected disorders that involve abnormal cranial shapes. Additionally, precise in-vivo quantitative imaging methods for assessing joint cranial and brain shape in inf ants will be developed in this project and will serve as invaluable tools for physicians to better assess, diagnose, and plan treatment for infant cranial deformities in the future.

项目总结