Chronic Kidney Diseases of Uncertain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium - SDCC

农业社区病因不明的慢性肾脏病 (CKDu) (CURE) 研究联盟 - SDCC

基本信息

批准号：
10300125
负责人：
DANIEL R BROOKS
金额：
$ 123.8万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-25 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10300125
关键词：
Address Affect Agreement Asia Behavioral Biological Biological Markers Biometry Biopsy Specimen Boston Case-Control Studies Central America Central Asia Chronic Kidney Failure Clinical Clinical Treatment Collaborations Colorado Communication Consensus Coordination and Collaboration Data Data Analyses Data Collection Data Coordinating Center Data Reporting Data Science Decision Making Development Diabetes Mellitus Disease Disease Progression Doctor of Philosophy El Salvador Eligibility Determination Enrollment Ensure Environmental Health Environmental Monitoring Environmental Pollution Environmental Risk Factor Epidemiologist Epidemiology Equipment Ethics Etiology Family health status Fostering Generations Genetic Genetic Determinism Geography Health Healthcare Systems Human Hypertension India Individual Infection Infrastructure International Intervention Kidney Kidney Diseases Laboratories Lead Leadership Life Logistics Longitudinal Studies Management Information Systems Manuals Medical Monitor Morbidity - disease rate Nephrology Nicaragua Occupational Occupational Health Outcome Pathway interactions Patients Policies Principal Investigator Privatization Procedures Productivity Protocols documentation Questionnaires Recording of previous events Reporting Research Research Design Research Personnel Research Support Resources Risk Risk Factors Role Science Services Shipping Site Specific qualifier value Specimen Sri Lanka System Technology Training United States National Institutes of Health Universities Variant Vision Visualization software Work agricultural community analytical method biobank cohesion cohort community based participatory research data dissemination data tools data visualization disorder control electronic data capture system epidemiology study experience follow-up human subject protection interest kidney biopsy kidney dysfunction local economy meetings men mortality multidisciplinary novel programs public health intervention research study sample collection scientific organization sound therapeutic target tool web site

项目摘要

PROJECT SUMMARY/ABSTRACT A growing number of geographically diverse regions around the world report increasing rates of chronic kidney disease of uncertain or unknown etiology (CKDu), a life-threatening condition not attributable to traditional chronic kidney disease risk factors. Yet, the etiology of CKDu remains unclear and data are lacking on CKDu progression, biological manifestations, genetic determinants, and risk factors that may explain regional variations. To address these challenges, the National Institutes of Health has formed the Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium. The Consortium will develop a harmonized study protocol that can be implemented in multiple endemic regions to understand the etiologies of CKDu and disease progression and to identify potential therapeutic targets and public health interventions. RTI International and Boston University along with our partners from Harvard University, National Autonomous University of Nicaragua, University of Colorado, and Stanford University, propose to establish the CURE Research Consortium Scientific Data Coordinating Center (SDCC). The SDCC will provide the leadership, infrastructure, and tools to unite the Field Epidemiology Sites, Renal Science Core, Human Health Exposure Analysis Resource, and NIH into a cohesive whole by promoting consensus building and collaborative decision making. The SDCC's role in cultivating a common research agenda is crucial to the CURE Research Consortium's ability to implement ethical epidemiology research designs; common approaches for data collection, and biological and environmental assessments; best practices for data analysis and dissemination; and ancillary research studies. Specifically, the SDCC will support the Research Consortium by accomplishing the following aims: (1) elucidate the likely multifactorial etiologies of CKDu development and progression in endemic regions by integrating a classic case-control study with longitudinal assessments of cases to assess factors for disease progression and controls to capture CKDu development; (2) promote consensus building and foster collaboration and coordination by providing scientific leadership, expertise in data science and robust analytical methods, and communication, logistical, and operational support; and (3) enhance Consortium research efficiency, productivity, and scientific rigor by providing sound study monitoring and oversight and establishing efficient data and specimen management systems using relevant technology and data visualization tools. Together with a multidisciplinary team of Co-investigators, the SDCC multiple PIs, Jill Lebov, PhD (contact PI), Marie Gantz, PhD, and Daniel Brooks, PhD, bring the required scientific and organizational capabilities in Consortium coordination, project management, epidemiology, biostatistics, data science, nephrology and kidney disease research, environmental and occupational health, genetics, and ethical conduct of international research in resource-limited settings to effectively manage the activities of the SDCC, the CURE Research Consortium, and the CURE Study.

项目摘要/摘要越来越多的世界各地的地理不同地区报告提高了慢性肾脏的速度不确定或未知病因（CKDU）的疾病，这种威胁生命的疾病不归因于传统慢性肾脏疾病危险因素。然而，CKDU的病因尚不清楚，并且缺乏CKDU的数据进展，生物表现，遗传决定因素和危险因素可能解释区域变化。为了应对这些挑战，美国国立卫生研究院已经形成了慢性肾脏农业社区（治疗）研究联盟中不确定病因（CKDU）的疾病。这财团将制定一个协调的研究方案，可以在多个地方性地区实施了解CKDU和疾病进展的病因，并确定潜在的治疗靶标和公共卫生干预措施。 RTI国际大学和波士顿大学以及哈佛大学的合作伙伴大学，尼加拉瓜国家自治大学，科罗拉多大学和斯坦福大学提议建立CURE研究联盟科学数据协调中心（SDCC）。 SDCC 将提供领导，基础设施和工具，以团结现场流行病学网站，肾科学核心，人类健康暴露分析资源，并通过促进共识建设来融入整体和协作决策。 SDCC在培养共同研究议程中的作用对治愈研究联盟实施道德流行病学研究设计的能力；常见的数据收集以及生物和环境评估的方法；数据分析的最佳实践和传播；和辅助研究。具体而言，SDCC将支持研究通过实现以下目的，财团：（1）阐明CKDU的可能多因素病因通过将经典的病例对照研究与纵向整合到地方性地区的发展和发展评估案例以评估疾病进展和对照因素以捕获CKDU发育的因素；（2）通过提供科学领导才能促进共识建立和促进协作和协调数据科学和强大的分析方法以及沟通，后勤和运营方面的专业知识支持; （3）通过提供声音来提高财团的研究效率，生产力和科学严格性研究监控和监督，并使用相关技术和数据可视化工具。与一个跨学科的共同评估者团队一起， SDCC多个PIS，Jill Lebov，博士（联系PI），PI），Marie Gantz，PhD和Daniel Brooks，PhD，带来在财团协调，项目管理中，需要科学和组织能力流行病学，生物统计学，数据科学，肾脏病和肾脏疾病研究，环境和环境在资源有限的环境中，国际研究的职业健康，遗传学和道德行为有效地管理SDCC，CURE研究联盟和治疗研究的活动。