Third International Workshop on Mesoamerican Nephropathy and Other CKDu

摘要 原因不明的慢性肾脏病（CKDu）的流行，也称为 中美洲的中美洲肾病（Mesoamerican Nephropathy，MeN）， 生活在沿着太平洋沿岸贫困条件下的工人和其他体力劳动者 墨西哥和中美洲。自1990年代对这一流行病的认识出现以来， 造成成千上万人死亡，特别是年轻人的死亡。 尽管研究取得了进展，但这种疾病的病因仍不清楚。类似的爆发， 世界其他地区，如斯里兰卡和印度，提出了一个问题， 疾病可能发生在中美洲以外。基于医生的轶事证据 报道称，美国也可能受到影响。了解这种疾病 仍然是一个谜，有一件事是明确的：为了解决研究问题和解决 病人的需要，需要国际和跨学科的合作。基础上 第三届中美洲肾病国际研讨会， 其他CKDu将汇集大约120名研究人员，临床医生和公共卫生 来自世界各地的专家。乘务员将总结和更新当前状态的 知识，并将其转化为研究议程，以确定疾病的原因， 针对初级预防、筛查和监测的干预措施， 和负担得起的治疗方案。会议将围绕四个科学主题组织： 病因/机制、临床方面、疾病负担（包括监测）和社会 （三）预防措施（包括预防措施和政策）。本次研讨会将超越 从中美洲到其他受影响区域，特别是南亚。另外两项活动是 为接触关键人群而规划：为100名初级保健人员举办讲习班前课程 在受影响最严重的哥斯达黎加省， 中美洲的政策制定者。有几项活动专门针对青少年 培训班包括一次海报展示会和三次研讨会。会后 传播产品包括为关键行为者，包括决策者， 研究人员、卫生保健提供者和受影响的社区。

Abstract The epidemic of chronic kidney disease of unknown origin (CKDu), also referred to as Mesoamerican Nephropathy (MeN) in Central America, disproportionally affects agricultural workers and other manual laborers living in conditions of poverty along the Pacific coast of Mexico and Central America. Since awareness of the epidemic emerged in the 1990s, it has been responsible for many tens of thousands of deaths, particularly among young adults. Despite advances in research, the etiology of this disease remains unclear. Similar outbreaks in other parts of the world such as Sri Lanka and India raise the question of whether the same disease might be occurring outside Mesoamerica. Anecdotal evidence based on physician reports suggest that the United States may also be affected. Understanding this disease remains an enigma and one thing is clear: in order to solve research questions and address patient needs, there is a need for international and interdisciplinary collaboration. Building on previous workshops, the Third International Workshop on Mesoamerican Nephropathy and Other CKDu will bring together approximately 120 researchers, clinicians, and public health specialists from around the world. Attendess will summarize and update the current state of the knowledge and translate it into research agendas for identifying the cause(s) of the disease and for interventions directed towards primary prevention, screening, and surveillance, and effective and affordable treatment protocols. The meeting will be organized around four scientific themes: etiology/mechanisms, clinical aspects, disease burden (including surveillance), and societal response (including preventive interventions and policies). This workshop will reach beyond Mesoamerica to other affected regions, particularly South Asia. Two additional activities are planned in order to reach key populations: a pre-workshop course for 100 primary care providers in the most affected province of Costa Rica and a post-workshop session for high- level policy makers in Central America. Several activities are aimed specifically at junior investigators and trainees, including a poster session and three seminars. Post-conference dissemination products include executive summaries for key actors, including policy makers, researchers, health care providers and affected communities.