Effects of daily low oxygen exposure on weight status, body composition, and metabolic health

每日低氧暴露对体重状况、身体成分和代谢健康的影响

• 批准号: 10299211
• 负责人: Claire E. Berryman
• 金额: $ 43.76万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-20 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10299211
• 关键词: Accelerometer; Adolescent; Affect; Altitude; American; Atmospheric Pressure; Blood; Body Composition; Body Weight; Body Weight decreased; Body fat; Caloric Restriction; Cardiovascular Diseases; Catecholamines; Cholecystokinin; Chronic; Chronic Disease; Desire for food; Diet; Disease; Double-Blind Method; Dual-Energy X-Ray Absorptiometry; Electrocardiogram; Energy Intake; Energy Metabolism; Environment; Exercise; Expenditure; Exposure to; Fasting; Health; Home; Hormones; Hour; Hunger; Hypoxia; Indirect Calorimetry; Individual; Intake; Intervention; Label; Lead; Leptin; Logistics; Malignant Neoplasms; Measures; Metabolic; Methods; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oregon; Outcome Study; Oxygen; Peptide YY; Psychosocial Factor; Public Health; Questionnaires; Randomized; Randomized Clinical Trials; Risk Factors; Sea; Sleep; Standardization; System; Testing; Travel; Water; Weight; Weight maintenance regimen; Wrist; adult obesity; arm; cost; diet and exercise; doubly-labeled water; energy balance; feeding; food consumption; ghrelin; glucagon-like peptide 1; normoxia; obesity prevention; obesity treatment; prospective; remote location; response; tissue oxygenation; urinary; weight loss intervention

Project Summary/Abstract Obesity and associated metabolic conditions are a significant public health burden, costing the U.S. ~$150 billion annually. Obesity is both a disease, affecting 1 in 3 Americans, and a risk factor for other chronic diseases, such as cardiovascular disease, type 2 diabetes, and 13 forms of cancers. Diet and exercise are the cornerstone of obesity prevention and treatment. However, a considerable number of individuals are non-responsive to existing weight-loss interventions and obesity rates continue to rise. Therefore, non-conventional approaches are needed to supplement current weight-loss strategies. Daily exposure to low-oxygen conditions may aid in current weight- loss strategies. Moderate (1500-3500 m) and higher (≥ 3500 m) altitude environments are naturally hypoxic due to the lower atmospheric pressure (for reference, Denver, CO is ~1600 m and Mt. Hood in Oregon is ~3500 m). Studies show that sea-level natives exposed to moderate- or high- altitude continuously for 5 or more days lose weight, which is a consequence of prolonged reductions in blood and tissue oxygenation that lead to increased energy expenditure and decreased appetite. However, implementation of hypoxia as a means for weight loss has been limited, to date, by the logistical constraints of traveling to remote locations or access to an altitude chamber. A safe, less expensive, and more logistically feasible alternative is the use of commercially available, low-oxygen systems at sea level, which create a normobaric hypoxic environment. Whether in-home, overnight, normobaric hypoxic exposure, compared to normobaric normoxic exposure, promotes body mass loss in adults with obesity remains unknown. Furthermore, determinants of energy balance, including energy intake and expenditure, and their relative contribution to normobaric hypoxia-induced weight loss have not been investigated. The objective of the proposed double-blind, parallel-arm, randomized clinical trial is to evaluate changes in body weight and composition, assess determinants of energy balance (intake and expenditure), and measure modulators of energy balance, following 8 wk of calorie restriction (-500 kcal/d) in combination with either overnight exposure to normobaric hypoxia (8 h/night, 15% FiO2, ~2640 m) or normoxia (8 h/night, 21% FiO2), using a commercially available, in-home tent system, in adults with obesity. Chronic (8 weeks), overnight (8 hours/night) low oxygen exposure may provide a non-conventional approach to supplement current weight-loss strategies, inform new strategies to accelerate weight loss, aid long-term weight management efforts, and benefit metabolic health in individuals with obesity.

项目摘要/摘要 肥胖症和相关的代谢状况是伯恩（Burnen）的重要公共卫生，使 美国每年约1500亿美元。肥胖既是一种疾病，影响了三分之一的美国人，又影响了危险因素 用于其他慢性疾病，例如心血管疾病，2型糖尿病和13种形式 癌症。饮食和运动是预防肥胖和治疗的基石。但是， 大量个人对现有减肥干预措施无反应和 肥胖率继续上升。因此，需要非规定的方法来补充 当前的减肥策略。每天暴露于低氧条件可能有助于当前重量 - 损失策略。中度（1500-3500 m）和较高（≥3500m）的高度环境是 由于大气压力较低而自然缺氧（参考，丹佛，CO为〜1600 m 俄勒冈州的胡德山是〜3500 m）。研究表明，暴露于现代的海平面当地人 或连续5天或以上的高海拔减轻体重，这是延长的结果 减少血液和组织氧合，导致能量消耗增加和 食欲下降。但是，实施缺氧作为减肥手段的实施是 迄今为止，受到前往偏远位置或访问高度的后勤约束的限制 腔室。安全，便宜，更逻辑上可行的替代方案是使用 在海平面上的市售低氧系统，这会产生正常的低氧 环境。与内室，一夜，正常的低氧性暴露与 正常的正态暴露，促进肥胖成年人的体重损失仍然存在 未知。此外，确定能量平衡，包括能量摄入和支出， 它们对正常可氧性缺氧诱导的体重减轻的相对贡献尚未 调查。拟议的双盲，平行臂，随机临床试验的目的是 为了评估体重和成分的变化，评估确定能量平衡 （摄入和支出）和能量平衡的测量调节器，加上8周的卡路里 限制（-500 kcal/d）与过夜暴露于正常的缺氧（8个） H/Night，15％FIO2，〜2640 m）或Normoxia（8 h/night，21％fio2），使用市售， 在肥胖的成年人中，内部帐篷系统。慢性（8周），过夜（8小时/晚）低 氧气暴露可能提供一种非规定方法来补充当前体重减轻 策略，为加速体重减轻的新策略提供信息，帮助长期体重管理 努力，并使肥胖者的代谢健康受益。