Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression

青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学

• 批准号: 10597082
• 负责人: Mary Louise Woody
• 金额: $ 16.92万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597082
• 关键词: Address; Adolescence; Adolescent; Adolescent Development; Adult; Affect; Affective; Age; Anxiety; Attention; Biological; Brain; Buffers; Cognitive; Complement; Data Analyses; Daughter; Depressed mood; Development; Diagnostic; Disease; Electroencephalography; Environment; Feedback; Female Adolescents; Foundations; Frequencies; Functional Magnetic Resonance Imaging; Future; Goals; Grant; High Risk Woman; Intervention; Investigational Therapies; Laboratories; Link; Major Depressive Disorder; Measures; Mental Depression; Mentors; Methods; Modality; Modeling; Modification; Moods; Neurons; Neurosciences; Population; Positioning Attribute; Prevention; Price; Procedures; Process; Psychiatry; Randomized; Recording of previous events; Research; Research Personnel; Risk; Role; Sampling; Series; Silk; Specificity; Stimulus; Testing; Therapeutic; Time; Training; Training Activity; Translating; Universities; Visual Cortex; Visual evoked cortical potential; Work; Youth; affective neuroscience; attentional bias; brain based; burden of illness; career development; child depression; cost effective; depression model; depressive symptoms; design; directed attention; feasibility testing; girls; high risk; improved; indexing; longitudinal design; maternal depression; neural; neurofeedback; neurophysiology; novel; personalized intervention; prevent; programs; prospective; recruit; recurrent depression; response; skills; stressor; success; therapeutic target; visual stimulus

PROJECT SUMMARY Depression is a leading contributor to the global burden of disease, and rates of depression increase rapidly during adolescence, particularly for girls. Affect-biased attention is a putative mechanism underlying adolescent depression that may also represent a target for intervention. To better inform experimental therapeutics, this proposal tests a mechanistic model of the visuocortical dynamics underlying the role of affect-biased attention in the development of depression using a risk-enriched sample of adolescent girls with no history of major depression at baseline (n = 90). The proposal will use steady-state visual evoked potentials (SSVEPs), derived from EEG, to provide a temporally-sensitive biological index of attention to competing visual stimuli at the level of neuronal populations in the visual cortex. The candidate proposes that increased stimulus-driven attention to distracting negative stimuli (assessed using SSVEPs as a novel visuocortical probe), which occurs at the expense of goal-directed attention to task-relevant stimuli, serves as a mechanistic precursor in the development of adolescent depression. The study will use a repeated-measures multi-wave assessment of depressive symptoms and SSVEP indices of affect-biased attention. A pilot experimental manipulation will test a novel real time SSVEP neurofeedback training to target affect-biased attention. We hypothesize that SSVEP indices of affect-biased attention will characterize depressive symptoms at baseline (Aim 1) and predict future depressive symptoms (Aim 2) and that real time SSVEP neurofeedback training will ameliorate affect-biased attention and buffer mood reactivity (Aim 3). In the proposed K23, the candidate will expand on her strong foundation in vulnerability models of depression by gaining additional training in: 1) developmental cognitive-affective neuroscience, 2) neurophysiology and advanced SSVEP analysis, 3) longitudinal data analysis, and 4) experimental therapeutics. The Department of Psychiatry at the University of Pittsburgh provides the optimal scientific training environment to meet these career development goals. The candidate's mentors (Drs. Price, Silk, and Salisbury) and consultants (Drs. Akcakaya, Iyengar, Ladouceur, Pine, and Young) are ideally suited to guide the candidate's training given their combined expertise in the neuroscience of youth depression, neurophysiology, longitudinal high risk designs, and experimental therapeutics (including expertise in neurofeedback concepts and methods). This proposal will inform the design of larger R series grants that will test, for example, if SSVEP indices of affect-biased attention predict the onset of youth internalizing disorders and if real time SSVEP neurofeedback training can be used in personalized intervention/prevention. The proposed K23 will prepare the candidate to investigate mechanisms of adolescent depression and position her with the requisite skills to target these mechanisms therapeutically. This program of research has the potential to advance the field by improving the identification of adolescents at high risk for depression and identifying mechanistic targets of intervention during key developmental windows. ! !

项目概要 抑郁症是全球疾病负担的主要原因，并且抑郁症发病率迅速增加 在青春期，尤其是女孩。情感偏向注意力是一种假定的潜在机制 青少年抑郁症也可能是干预的目标。为了更好地为实验提供信息 疗法，该提案测试了视觉皮层动力学的机制模型 使用患有抑郁症的青春期女孩的风险丰富样本来研究抑郁症发展中的情感偏向关注 基线时没有重度抑郁症病史 (n = 90)。该提案将使用稳态视觉诱发电位 （SSVEP），源自脑电图，提供对竞争性视觉注意力的时间敏感的生物指数 视觉皮层神经元群水平的刺激。候选人建议增加 刺激驱动的对分散注意力的负面刺激的注意力（使用 SSVEP 作为一种新型视觉皮层进行评估 探针），其发生以牺牲对任务相关刺激的目标导向注意力为代价，作为一种机制 青少年抑郁症发展的先兆。该研究将使用重复测量的多波 评估抑郁症状和情感偏向注意力的 SSVEP 指数。试点实验 操纵将测试一种新颖的实时 SSVEP 神经反馈训练，以针对情感偏向注意力。我们 假设情绪偏向注意力的 SSVEP 指数将表征基线的抑郁症状 （目标 1）并预测未来的抑郁症状（目标 2）以及实时 SSVEP 神经反馈训练将 改善情感偏向性注意力并缓冲情绪反应（目标 3）。在拟议的 K23 中，候选人将 通过接受以下方面的额外培训，拓展她在抑郁症脆弱性模型方面的坚实基础：1) 发育认知情感神经科学，2) 神经生理学和高级 SSVEP 分析，3) 纵向数据分析，4) 实验疗法。大学精神病学系 匹兹堡提供了最佳的科学培训环境来实现这些职业发展目标。这 候选人的导师（Price、Silk 和 Salisbury 博士）和顾问（Akcakaya、Iyengar、Ladouceur 博士、 鉴于他们在以下方面的综合专业知识，Pine 和 Young）非常适合指导候选人的培训 青少年抑郁症的神经科学、神经生理学、纵向高风险设计和实验 治疗学（包括神经反馈概念和方法方面的专业知识）。该提案将告知 设计更大的 R 系列赠款，例如，将测试情感偏向注意力的 SSVEP 指数是否可以预测 青少年内化障碍的发生以及实时 SSVEP 神经反馈训练是否可以用于 个性化干预/预防。拟议的 K23 将使候选人为调查机制做好准备 青少年抑郁症的研究，并为她提供必要的技能来针对这些机制进行治疗。 该研究计划有可能通过改善青少年的识别来推动该领域的发展 抑郁症的高风险并确定关键发育窗口期间干预的机械目标。 ！ ！

项目成果

Using Neurofeedback from Steady-State Visual Evoked Potentials to Target Affect-Biased Attention in Augmented Reality.

• DOI: 10.1109/embc48229.2022.9871982
• 发表时间: 2022-07
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Racial Stress and Trauma and the Development of Adolescent Depression: A Review of the Role of Vigilance Evoked by Racism-Related Threat.

• DOI: 10.1177/24705470221118574
• 发表时间: 2022-01
• 期刊: Chronic stress (Thousand Oaks, Calif.)
• 作者: Woody, Mary L;Bell, Elizabeth C;Cruz, Nicolas A;Wears, Anna;Anderson, Riana E;Price, Rebecca B
• 通讯作者: Price, Rebecca B