Social and Genetic Contributions to Children's Sleep, Health and Functioning

社会和遗传对儿童睡眠、健康和功能的贡献

• 批准号: 10307117
• 负责人: Leah Darrah Doane Sampey
• 金额: $ 63.75万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-15 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10307117
• 关键词: Accounting; Acute; Address; Adolescence; Adolescent; Adolescent Development; Aerobic; Affect; Age; Anxiety; Arizona; Biological; Biological Markers; Birth Records; Centers for Disease Control and Prevention (U.S.); Characteristics; Child; Child Welfare; Childhood; Cognition; Collaborations; Communities; Complex; Data; Development; Developmental Process; Diagnosis; Disease; Environment; Environmental Exposure; Environmental Risk Factor; Exhibits; Genes; Genetic; Genetic Models; Genetic Risk; Genetic study; Goals; Growth; Health; Health Psychology; Heritability; Home; Hydrocortisone; Inflammation; Inflammatory; Intercept; Intervention; Knowledge; Link; Measurement; Measures; Mediating; Mental Depression; Mental Health; Modeling; Morbidity - disease rate; Muscle; Obesity; Outcome; Outcome Assessment; Pathway interactions; Pattern; Physiological; Physiological Processes; Physiology; Play; Prevention; Process; Psyche structure; Puberty; Reporting; Research; Risk; Risk Factors; Role; Sampling; Sleep; Sleep Disorders; Specific qualifier value; Specificity; Stress; Symptoms; Time; Twin Multiple Birth; Twin Studies; Work; Youth; base; design; experience; genetic approach; health disparity; inattention; infancy; mortality; novel; perceived stress; physical conditioning; poor sleep; preventive intervention; pubertal timing; public health relevance; recruit; resilience; sleep health; sleep quality; social; social culture; social media; socioeconomic disparity; socioeconomics; substance use

Project Summary With our ethnically and socioeconomically diverse longitudinal twin study, in this competing continuation we aim to understand the genetic and environmental mechanisms linking sleep and physical health across pubertal development. We also elucidate mechanisms accounting for longitudinal associations between these health processes and both mental health and inflammation in adolescence. Further, we examine a key proximal sociocultural process - daily media use - which is pervasive in the everyday lives of adolescents. With inflammation and mental health problems on the rise among youth, it is imperative that we utilize a well- powered (N=700 twin youth), representative (recruited from birth records), genetically-informed (twin study), longitudinal (followed since infancy with proposed assessments at 12 and 14 years) design to identify risk and resilience processes across the major transition from childhood to adolescence. To date, our results suggest that sleep is linked with cognition and health for genetic rather than environmental reasons (see C1), suggesting that third variables are involved that may vary by development (puberty). More specifically, we add two follow ups of a diverse twin sample recruited from birth records and assessed at 1, 2, 5, 8, 9, 10 & 11 years (N=700 youth; Arizona Twin Project). At 12 years, we add new assessments of the environment (e.g. media use) and extend our objective measures of sleep and health (aerobic, muscular, adiposity, physiology). At age 14, we add new outcome assessments (inflammatory biomarkers, mental health). Under Aim 1, we use parallel process growth models from childhood into adolescence to determine direction of effects among puberty, sleep, and multiple indicators of health. Under Aim 2, we dynamically extend this work by using intercepts and growth parameters from the parallel process growth models outlined in Aim 1 to predict inflammation and mental health at age 14. Under Aim 3, we examine the genetic and environmental overlap among puberty, sleep, and health and pinpoint aspects of the environment that play a role in health. Such an examination is critical as our work has shown that common risk factors and health are often associated for genetic as opposed to environmental reasons which can shift the focus of potential interventions. Under Aim 4, we disentangle genetic and environmental contributions to associations between daily sociocultural contexts, sleep and health. The proposed study builds on existing collaborations with complementary expertise. The project is notable as it is the only twin sample of youth to obtain longitudinal objective sleep, health, and sociocultural context data, for its developmental cultural and genetic approach that uncovers gene-environment interplay, measurement of physiological and inflammation biomarkers, and examination of proximal sociocultural processes including objective media use in adolescence. Combining these design features exponentially increases the scientific contribution, elucidating processes that support preventive intervention efforts.

项目摘要 通过我们的种族和社会经济多样性的纵向双胞胎研究，在这个竞争性的延续中， 旨在了解将睡眠和身体健康联系起来的遗传和环境机制， 青春期发育我们还阐明了机制占纵向协会之间的这些 健康过程和心理健康和青春期炎症。此外，我们研究了一个关键 最接近的社会文化进程-日常媒体使用-在青少年的日常生活中普遍存在。与 炎症和心理健康问题在年轻人中的上升，我们必须利用一个良好的， 动力（N=700双胞胎青年），代表性（从出生记录中招募），遗传学信息（双胞胎研究）， 纵向设计（从婴儿期开始，在12岁和14岁时进行拟议的评估）， 从童年到青春期的主要过渡期的复原力过程。到目前为止，我们的结果表明， 睡眠与认知和健康的关系是遗传的，而不是环境的原因（见C1）， 这表明第三个变量可能会随着发育（青春期）而变化。更具体地说，我们添加 从出生记录中招募的不同双胞胎样本的两次随访，并在1，2，5，8，9，10和11进行评估 年（N=700青年;亚利桑那州孪生项目）。12年后，我们增加了新的环境评估（例如： 媒体使用），并扩展我们的睡眠和健康的客观措施（有氧，肌肉，肥胖，生理）。 在14岁时，我们增加了新的结果评估（炎症生物标志物，心理健康）。在目标1下，我们使用 从童年到青春期的平行过程增长模型，以确定 青春期、睡眠和多项健康指标。在目标2下，我们通过使用 截距和目标1中概述的并行过程增长模型的增长参数，以预测 炎症和心理健康的关系。在目标3下，我们研究了遗传和环境的重叠 在青春期，睡眠和健康之间，并指出环境在健康中发挥作用的方面。这样的 检查是至关重要的，因为我们的工作表明，常见的风险因素和健康往往与 与环境原因相反，遗传原因可能会改变潜在干预措施的重点。根据目标4， 我们解开了遗传和环境对日常社会文化背景之间联系的贡献， 睡眠与健康拟议的研究建立在现有的具有互补专门知识的合作基础上。的 该项目是值得注意的，因为它是唯一的青年双胞胎样本，以获得纵向客观的睡眠，健康， 社会文化背景数据，其发展的文化和遗传方法，揭示了基因环境 相互作用、生理和炎症生物标志物的测量以及近端 社会文化过程，包括青少年客观使用媒体。结合这些设计特征 成倍增加科学贡献，阐明支持预防性干预的过程 努力