Social and Genetic Contributions to Children's Sleep, Health and Functioning

社会和遗传对儿童睡眠、健康和功能的贡献

• 批准号: 10534668
• 负责人: Leah Darrah Doane Sampey
• 金额: $ 62.19万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-15 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10534668
• 关键词: Accounting; Acute; Address; Adolescence; Adolescent; Adolescent Development; Adult; Aerobic; Affect; Age; Anxiety; Arizona; Biological; Biological Markers; Birth Records; Characteristics; Child; Child Welfare; Childhood; Cognition; Collaborations; Communities; Complex; Data; Development; Developmental Process; Diagnosis; Disease; Emotional; Environment; Environmental Exposure; Environmental Risk Factor; Ethnic Origin; Exhibits; Genes; Genetic; Genetic Models; Genetic Risk; Genetic study; Goals; Growth; Health; Health Psychology; Heritability; Home; Hydrocortisone; Inflammation; Inflammatory; Intercept; Intervention; Knowledge; Link; Measurement; Measures; Mediating; Mental Depression; Mental Health; Modeling; Morbidity - disease rate; Muscle; Obesity; Outcome; Outcome Assessment; Pathway interactions; Pattern; Physiological; Physiological Processes; Physiology; Prevention; Process; Puberty; Reporting; Research; Risk; Risk Factors; Role; Sampling; Sleep; Sleep Disorders; Specific qualifier value; Specificity; Stress; Symptoms; Time; Twin Multiple Birth; Twin Studies; Weight; Work; Youth; conduct problem; design; experience; genetic approach; health disparity; inattention; infancy; mortality; novel; perceived stress; physical conditioning; poor sleep; preventive intervention; pubertal timing; public health relevance; recruit; resilience; sleep health; sleep quality; social; social culture; social media; socioeconomic disparity; socioeconomics; substance use

Project Summary With our ethnically and socioeconomically diverse longitudinal twin study, in this competing continuation we aim to understand the genetic and environmental mechanisms linking sleep and physical health across pubertal development. We also elucidate mechanisms accounting for longitudinal associations between these health processes and both mental health and inflammation in adolescence. Further, we examine a key proximal sociocultural process - daily media use - which is pervasive in the everyday lives of adolescents. With inflammation and mental health problems on the rise among youth, it is imperative that we utilize a well- powered (N=700 twin youth), representative (recruited from birth records), genetically-informed (twin study), longitudinal (followed since infancy with proposed assessments at 12 and 14 years) design to identify risk and resilience processes across the major transition from childhood to adolescence. To date, our results suggest that sleep is linked with cognition and health for genetic rather than environmental reasons (see C1), suggesting that third variables are involved that may vary by development (puberty). More specifically, we add two follow ups of a diverse twin sample recruited from birth records and assessed at 1, 2, 5, 8, 9, 10 & 11 years (N=700 youth; Arizona Twin Project). At 12 years, we add new assessments of the environment (e.g. media use) and extend our objective measures of sleep and health (aerobic, muscular, adiposity, physiology). At age 14, we add new outcome assessments (inflammatory biomarkers, mental health). Under Aim 1, we use parallel process growth models from childhood into adolescence to determine direction of effects among puberty, sleep, and multiple indicators of health. Under Aim 2, we dynamically extend this work by using intercepts and growth parameters from the parallel process growth models outlined in Aim 1 to predict inflammation and mental health at age 14. Under Aim 3, we examine the genetic and environmental overlap among puberty, sleep, and health and pinpoint aspects of the environment that play a role in health. Such an examination is critical as our work has shown that common risk factors and health are often associated for genetic as opposed to environmental reasons which can shift the focus of potential interventions. Under Aim 4, we disentangle genetic and environmental contributions to associations between daily sociocultural contexts, sleep and health. The proposed study builds on existing collaborations with complementary expertise. The project is notable as it is the only twin sample of youth to obtain longitudinal objective sleep, health, and sociocultural context data, for its developmental cultural and genetic approach that uncovers gene-environment interplay, measurement of physiological and inflammation biomarkers, and examination of proximal sociocultural processes including objective media use in adolescence. Combining these design features exponentially increases the scientific contribution, elucidating processes that support preventive intervention efforts.

项目摘要 随着我们种族和社会经济多样化的纵向双胞胎研究，在这一竞争的继续中，我们 旨在了解将睡眠和身体健康联系起来的遗传和环境机制 青春期发育。我们还阐明了解释这些之间的纵向关联的机制 健康过程以及青春期的心理健康和炎症。此外，我们还检查了一个密钥 最近的社会文化进程--日常媒体使用--普遍存在于青少年的日常生活中。使用 炎症和心理健康问题在年轻人中不断上升，我们必须充分利用- 有能力(N=700名双胞胎青年)，代表(从出生记录中招募)，遗传知情(双胞胎研究)， 纵向(从婴儿期开始跟踪，建议在12岁和14岁进行评估)旨在识别风险和 复原力在从童年到青春期的主要过渡过程中进行。到目前为止，我们的结果表明 睡眠与认知和健康联系在一起是因为遗传原因，而不是环境原因(见c1)， 这表明涉及的第三个变量可能会因发育(青春期)而异。更具体地说，我们添加了 从出生记录中招募的不同双胞胎样本的两次随访，分别在1、2、5、8、9、10和11岁进行评估 年(N=700名青年；亚利桑那州双胞胎计划)。在12年后，我们增加了新的环境评估(例如 媒体使用)，并扩展我们对睡眠和健康(有氧、肌肉、肥胖、生理学)的客观衡量标准。 在14岁时，我们增加了新的结果评估(炎症生物标记物、精神健康)。在目标1下，我们使用 从童年到青春期的平行过程生长模型确定影响的方向 青春期、睡眠和多种健康指标。在目标2下，我们通过使用 从目标1中概述的并行过程生长模型中截获和生长参数以预测 14岁时的炎症和心理健康。在目标3下，我们检查了遗传和环境的重叠 在青春期、睡眠和健康之间，并准确地找出环境中对健康起作用的方面。这样的一种 检查是至关重要的，因为我们的研究表明，常见的风险因素和健康通常与 遗传原因，而不是环境原因，这可能会转移潜在干预的重点。在目标4下， 我们解开了遗传和环境对日常社会文化背景之间的联系的贡献， 睡眠和健康。拟议的研究建立在现有合作的基础上，具有互补的专业知识。这个 项目是值得注意的，因为它是唯一的双胞胎青年样本，获得纵向目标睡眠，健康，和 社会文化背景数据，因为其发展的文化和遗传方法揭示了基因环境 相互作用，生理和炎症生物标记物的测量，以及近端的检查 社会文化过程，包括青春期的客观媒体使用。将这些设计特点结合起来 成倍地增加科学贡献，阐明支持预防性干预的过程 努力。