Oral Microbiome: Beyond Bacteria

口腔微生物组：超越细菌

• 批准号: 10318787
• 负责人: Xuesong He
• 金额: $ 0.9万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318787
• 关键词: Bacteria; Bacteriophages; Biological; Communities; Culture-independent methods; Dental Research; Diagnosis; Disease; Ecosystem; Female; Health; Infection; Institutes; International; Knowledge; Methods; Minority Groups; Molecular; Oral; Oral cavity; Organism; Radiation; Research; Research Personnel; Scientist; System; Underrepresented Populations; Viral; Virus; Work; Yang; bacteriome; biological research; career; disability; fungus; host-microbe interactions; improved; insight; member; microbial; microbiome research; microorganism; mycobiome; nanosized; oral microbial community; oral microbiome; posters; symposium

This R13 proposal seeks support for Forsyth Symposium 2021 “Oral Microbiome: Beyond Bacteria” at the Forsyth Institute on October 28-29, 2021. The overall objective of the symposium is to promote better understanding of oral microbiome from a holistic perspective. Oral microbiome is composed of diverse bacterial species, fungal and viral (bacteriophage) components, as well as recently identified nano-sized parasitic Candidate Phyla Radiation (CPR) organisms. Effective management of oral microbiome-related diseases calls for a more comprehensive understanding of the impact of the oral microbiota on host health and disease, which requires a holistic view of intra- and cross-kingdom interactions among different members of the oral microbiome (including bacteria, fungi, phages and CPR organisms), as well as microbial-host interaction. The symposium will bring together a group of scientists with diverse research backgrounds in oral microbiome (including oral bacsteriome, mycobiome, phageome and CPR) and different career stages to share their research and ideas. The Symposium will include poster presentations by attendees and talks by: Ann Griffen, Matthew M. Ramsey, Hyun (Michel) Koo, Jill Banfield, Mircea Podar, Jeff McLean, Xuesong He, Kathryn Kauffman, David Moyes, Mahmoud Ghannoum, Patricia Diaz, Jessica Mark Welch, Yang-Yu Liu, and Anna Edlund. Another key objective is to identify biological questions and technical roadblocks that must be overcome to achieve a more comprehensive understanding of the impact of the oral microbiota on host health and disease from a holistic point of view. Meanwhile, the symposium will promote new collaborative researches which will expand from bacterial interspecies interactions to inter-kingdom interactions which include bacteria, CPR, fungi, and phages. It will also provide a great opportunity for trainees to interact with experts in the field and promote their research. More importantly, by encouraging female trainees and trainees with disabilities or of minority groups, the symposium aims to promote the engagement of underrepresented groups in dental research. The conference will create a community of investigators who have previously resided in scientific silos that did not meet or communicate with each other: oral bacteriome, mycobiome, phageome and CPR. These investigators will now communicate and hopefully develop collaborative research to achieve a fundamental understanding of oral microbiome from a holistic perspective, which will ultimately improve our ability to diagnose and treat microbial infections.

本R13提案寻求对福赛斯2021年研讨会“口腔微生物组：超越细菌”的支持， 2021年10月28日至29日，福赛斯研究所。研讨会的总体目标是更好地促进 从整体角度理解口腔微生物组。口腔微生物组由多种 细菌物种、真菌和病毒（噬菌体）成分，以及最近鉴定的纳米尺寸的 寄生候选辐射门（CPR）生物。有效管理口腔微生物组相关疾病 疾病需要更全面地了解口腔微生物群对宿主健康的影响 和疾病，这需要对不同成员之间的内部和跨王国相互作用的整体观点 口腔微生物组（包括细菌、真菌、真菌和CPR生物）以及微生物宿主 互动研讨会将汇集一批具有不同研究背景的科学家， 微生物组（包括口腔细菌组，真菌组，噬菌体组和CPR）和不同的职业阶段， 分享他们的研究和想法。研讨会将包括与会者的海报展示和以下人士的讲座： 放大图片作者：Ann格里芬，Matthew M. Ramsey，Hyun（Michel）Koo，Jill Banfield，Mircea Podar，Jeff姆克林，Xuesong He， 凯瑟琳·考夫曼、大卫·莫耶斯、马哈茂德·加努姆、帕特里夏·迪亚兹、杰西卡·马克·韦尔奇、刘洋宇和 安娜艾德伦德。另一个关键目标是确定必须解决的生物学问题和技术障碍。 更全面地了解口腔微生物群对宿主健康的影响 和疾病的关系。同时，研讨会将促进新的合作， 研究将从细菌种间相互作用扩展到王国间相互作用， 包括细菌、CPR、真菌和真菌。它还将为学员提供一个很好的机会， 该领域的专家，并促进他们的研究。更重要的是，通过鼓励女性学员和 研讨会的目的，是促进残疾人士或少数族裔人士的参与， 牙科研究中代表性不足的群体。会议将创建一个调查人员社区， 以前居住在科学筒仓，没有满足或相互沟通：口腔细菌组， 真菌组噬菌体组和心肺复苏术这些调查人员现在将进行交流， 合作研究，从整体角度对口腔微生物组进行基本了解， 这将最终提高我们诊断和治疗微生物感染的能力。