Lakeside Conference on Protein Toxins and Effectors 2021

2021 年湖畔蛋白质毒素和效应物会议

• 批准号: 10318832
• 负责人: Karla J F Satchell
• 金额: $ 0.8万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318832
• 关键词: Address; American; Area; Award; Bacteria; Biochemical; Biology; COVID-19 pandemic; Cell physiology; Cells; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communicable Diseases; Communication; Communities; Cryoelectron Microscopy; Disease; Ecosystem; Ensure; Eukaryotic Cell; Feedback; Fees; Funding; Future; Goals; Growth; Hybrids; Illinois; Intention; Knowledge; Laboratories; Lead; Microbe; Microscopy; Minority; Modeling; National Institute of Allergy and Infectious Disease; North America; Oral; Organism; Participant; Pathogenesis; Persons; Phylogenetic Analysis; Postdoctoral Fellow; Proteins; Proteomics; Request for Applications; Research; Resolution; Resort; Resources; Rod; Role; Scholarship; Scientist; Services; Shapes; Structural Biologist; Structure; Students; Surveys; Syringes; System; Testing; Texas; Toxin; Translations; Travel; Type IV Secretion System Pathway; Underrepresented Minority; United States National Institutes of Health; Universities; Vaccines; Videoconferencing; Virulence Factors; Wisconsin; Woman; base; cytotoxic; fascinate; fighting; graduate student; human disease; innovation; interest; live stream; meetings; member; microbial; microbial community; microbial genomics; pathogen; pathogenic bacteria; posters; programs; screening; structural biology; success; symposium; virtual

PROJECT SUMMARY/ABSTRACT Protein toxins and effectors are primary virulence factors of many bacterial pathogens. They cause diseases by targeting and disrupting key cellular functions. Historically, research on toxins/effectors has focused on only a few major toxins, which has achieved tremendous successes in establishing the framework of their mechanisms and in eradicating many devastating infectious diseases. Building on these earlier successes, the field has gone through a great resurgence and expansion in the past 20 years, transforming from a narrow focus on a few human diseases to much broader areas of biology, centering on understanding “protein-based” fight-and- defense communications between co-evolving organisms. For instance, recent advances in microbial genomics and discovery-based screening approaches have led to a dramatic increase in the number of toxins and effector systems being studied. New research has also revealed that microbes secrete and inject toxins and effectors not only to target eukaryotic cells during pathogenesis, but also to engage in interbacterial competition. Technological advances in high-resolution microscopy, structural biology, cryo-electron microscopy, proteomics, and CRISPR have rapidly advanced our understanding of toxins/effectors action. Despite the growth of both the depth and breadth of the field, there is currently no meeting in North America centered on toxins/effectors that can bring people together from diverse fields. To address this gap, we are launching a reconfigured and reimagined “in person-virtual” hybrid conference, “Lakeside Conference on Protein Toxins and Effectors” (#LakesidePTE) to be held October 3-6, 2021 at the Abbey Resort in Lake Geneva, Wisconsin, USA, leveraging the participation and enthusiastic feedback received during our inaugural meeting in October 2020, which was entirely on-line. This newly hybrid conference will focus on the cellular, structural, and biochemical mechanisms of protein toxin and effector action and the translation of these proteins for treatment of human disease. The conference will be organized by Chair Karla Satchell at Northwestern University and Vice-Chair Steven Blanke at University of Illinois at Urbana-Champaign. A ten member scientific advisory board will assist in selection of speakers and abstract review. There will be 5 sessions and three keynote addresses (Dr. Rod Welch from University of Wisconsin; Dr. Theresa Koehler from University of Texas-Houston, and Dr. Craig Roy from Yale University). Ten additional invited speakers will anchor five scientific sessions that will be filled out with talks selected from abstracts. Here we are seeking NIAID funds 1) to support registration fee and travel for keynote and invited speakers, (2) to offer registration scholarship awards for underrepresented minority post-docs and graduate students and (3) for audiovisual support for a hybrid meeting that will be simultaneously live streamed. This support from NIAID will bring together microbiologists, biochemists, structural biologists, and biophysicists to encourage new collaborations across disease and phylogenetic boundaries and test an innovative model for the future of this conference as a hybrid conference that will reach a global audience.

项目总结/摘要 蛋白质毒素和效应物是许多细菌病原体的主要毒力因子。它们引起疾病的原因是 瞄准并破坏关键的细胞功能从历史上看，对毒素/效应物的研究只集中在一个 在建立其机制框架方面取得了巨大成功 以及根除许多毁灭性的传染病。在这些早期成功的基础上， 在过去的20年里，通过一个伟大的复兴和扩张，从一个狭隘的集中在少数几个 将人类疾病扩展到更广泛的生物学领域，以理解“基于蛋白质的”战斗和 共同进化的生物体之间的防御通信。例如，微生物基因组学的最新进展 基于发现的筛选方法导致毒素和效应物的数量急剧增加， 正在研究的系统。新的研究还揭示了微生物分泌和注入毒素和效应物 不仅在发病过程中靶向真核细胞，而且参与细菌间的竞争。 高分辨率显微镜、结构生物学、低温电子显微镜、蛋白质组学、 和CRISPR迅速推进了我们对毒素/效应物作用的理解。尽管两者的增长 由于该领域的深度和广度，目前在北美没有以毒素/效应物为中心的会议， 可以将不同领域的人聚集在一起。为了弥补这一差距，我们正在启动一个重新配置的， 重新想象“在人虚拟”混合会议，“湖畔会议蛋白质毒素和效应器” （#LakesidePTE）将于2021年10月3日至6日在美国威斯康星州日内瓦湖的修道院度假村举行，利用 我们在2020年10月的首次会议上收到的参与和热情反馈， 完全在线。这个新的混合会议将集中在细胞，结构和生化机制 蛋白质毒素和效应物作用的研究以及这些蛋白质的翻译用于治疗人类疾病。的 会议将由西北大学的主席卡拉·萨塔和副主席史蒂文·布兰克组织 伊利诺伊大学厄巴纳-香槟分校一个由十名成员组成的科学咨询委员会将协助挑选 演讲者和摘要评论将有5个会议和三个主题演讲（博士罗德韦尔奇从 威斯康星州大学;德克萨斯大学休斯顿分校的Theresa Koehler博士和耶鲁大学的克雷格罗伊博士 大学）。另外十位受邀演讲者将锚五场科学会议，会议将充满演讲 选自抽象。在这里，我们正在寻求NIAID资金1）支持注册费和主题演讲的差旅费 并邀请演讲者，（2）为代表性不足的少数民族博士后提供注册奖学金， 研究生;（3）为混合会议提供视听支持，同时进行流媒体直播。 来自NIAID的支持将汇集微生物学家，生物化学家，结构生物学家和生物制药学家 鼓励跨越疾病和系统发育界限的新合作，并测试一种创新模式， 这次会议的未来是一个混合会议，将达到全球观众。