Lakeside Conference on Protein Toxins and Effectors 2021

2021 年湖畔蛋白质毒素和效应物会议

• 批准号: 10318832
• 负责人: Karla J F Satchell
• 金额: $ 0.8万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318832
• 关键词: Address; American; Area; Award; Bacteria; Biochemical; Biology; COVID-19 pandemic; Cell physiology; Cells; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communicable Diseases; Communication; Communities; Cryoelectron Microscopy; Disease; Ecosystem; Ensure; Eukaryotic Cell; Feedback; Fees; Funding; Future; Goals; Growth; Hybrids; Illinois; Intention; Knowledge; Laboratories; Lead; Microbe; Microscopy; Minority; Modeling; National Institute of Allergy and Infectious Disease; North America; Oral; Organism; Participant; Pathogenesis; Persons; Phylogenetic Analysis; Postdoctoral Fellow; Proteins; Proteomics; Request for Applications; Research; Resolution; Resort; Resources; Rod; Role; Scholarship; Scientist; Services; Shapes; Structural Biologist; Structure; Students; Surveys; Syringes; System; Testing; Texas; Toxin; Translations; Travel; Type IV Secretion System Pathway; Underrepresented Minority; United States National Institutes of Health; Universities; Vaccines; Videoconferencing; Virulence Factors; Wisconsin; Woman; base; cytotoxic; fascinate; fighting; graduate student; human disease; innovation; interest; live stream; meetings; member; microbial; microbial community; microbial genomics; pathogen; pathogenic bacteria; posters; programs; screening; structural biology; success; symposium; virtual

PROJECT SUMMARY/ABSTRACT Protein toxins and effectors are primary virulence factors of many bacterial pathogens. They cause diseases by targeting and disrupting key cellular functions. Historically, research on toxins/effectors has focused on only a few major toxins, which has achieved tremendous successes in establishing the framework of their mechanisms and in eradicating many devastating infectious diseases. Building on these earlier successes, the field has gone through a great resurgence and expansion in the past 20 years, transforming from a narrow focus on a few human diseases to much broader areas of biology, centering on understanding “protein-based” fight-and- defense communications between co-evolving organisms. For instance, recent advances in microbial genomics and discovery-based screening approaches have led to a dramatic increase in the number of toxins and effector systems being studied. New research has also revealed that microbes secrete and inject toxins and effectors not only to target eukaryotic cells during pathogenesis, but also to engage in interbacterial competition. Technological advances in high-resolution microscopy, structural biology, cryo-electron microscopy, proteomics, and CRISPR have rapidly advanced our understanding of toxins/effectors action. Despite the growth of both the depth and breadth of the field, there is currently no meeting in North America centered on toxins/effectors that can bring people together from diverse fields. To address this gap, we are launching a reconfigured and reimagined “in person-virtual” hybrid conference, “Lakeside Conference on Protein Toxins and Effectors” (#LakesidePTE) to be held October 3-6, 2021 at the Abbey Resort in Lake Geneva, Wisconsin, USA, leveraging the participation and enthusiastic feedback received during our inaugural meeting in October 2020, which was entirely on-line. This newly hybrid conference will focus on the cellular, structural, and biochemical mechanisms of protein toxin and effector action and the translation of these proteins for treatment of human disease. The conference will be organized by Chair Karla Satchell at Northwestern University and Vice-Chair Steven Blanke at University of Illinois at Urbana-Champaign. A ten member scientific advisory board will assist in selection of speakers and abstract review. There will be 5 sessions and three keynote addresses (Dr. Rod Welch from University of Wisconsin; Dr. Theresa Koehler from University of Texas-Houston, and Dr. Craig Roy from Yale University). Ten additional invited speakers will anchor five scientific sessions that will be filled out with talks selected from abstracts. Here we are seeking NIAID funds 1) to support registration fee and travel for keynote and invited speakers, (2) to offer registration scholarship awards for underrepresented minority post-docs and graduate students and (3) for audiovisual support for a hybrid meeting that will be simultaneously live streamed. This support from NIAID will bring together microbiologists, biochemists, structural biologists, and biophysicists to encourage new collaborations across disease and phylogenetic boundaries and test an innovative model for the future of this conference as a hybrid conference that will reach a global audience.

项目概要/摘要 蛋白质毒素和效应子是许多细菌病原体的主要毒力因子。它们通过以下方式引起疾病 靶向和破坏关键的细胞功能。从历史上看，对毒素/效应物的研究仅集中于 少数主要毒素在建立其机制框架方面取得了巨大成功 并消除许多毁灭性的传染病。在这些早期成功的基础上，该领域已经发展起来 经过过去20年的伟大复兴和扩张，从狭隘地关注少数人转变为 人类疾病扩展到更广泛的生物学领域，重点是理解“基于蛋白质的”斗争 共同进化生物之间的防御通讯。例如，微生物基因组学的最新进展 基于发现的筛选方法导致毒素和效应物的数量急剧增加 正在研究的系统。新的研究还表明微生物会分泌和注入毒素和效应物 不仅在发病过程中靶向真核细胞，而且还参与细菌间的竞争。 高分辨率显微镜、结构生物学、冷冻电子显微镜、蛋白质组学、 和 CRISPR 迅速增进了我们对毒素/效应子作用的理解。尽管两者均有所增长 从该领域的深度和广度来看，目前北美还没有以毒素/效应物为中心的会议 可以将不同领域的人们聚集在一起。为了解决这一差距，我们正在启动一个重新配置和 重新构想的“面对面-虚拟”混合会议“蛋白质毒素和效应物湖畔会议” (#LakesidePTE) 将于 2021 年 10 月 3 日至 6 日在美国威斯康星州日内瓦湖修道院度假村举行，利用 2020 年 10 月首次会议期间的参与和热情反馈 完全在线。这次新的混合会议将重点关注细胞、结构和生化机制 蛋白质毒素和效应器作用的研究以及这些蛋白质用于治疗人类疾病的翻译。这 会议将由西北大学主席 Karla Satchell 和副主席 Steven Blanke 组织 在伊利诺伊大学厄巴纳-香槟分校。十名成员的科学顾问委员会将协助选择 演讲者和摘要评论。将举行 5 场会议和 3 场主题演讲（来自 威斯康星大学；德克萨斯大学休斯顿分校的 Theresa Koehler 博士和耶鲁大学的 Craig Roy 博士 大学）。另外十位受邀演讲者将主持五场科学会议，其中将包括演讲 选自摘要。我们在此寻求 NIAID 资金 1) 支持注册费和主题演讲差旅费 并邀请演讲者，(2) 为代表性不足的少数族裔博士后提供注册奖学金， 研究生和 (3) 为将同时进行直播的混合会议提供视听支持。 NIAID 的支持将汇集微生物学家、生物化学家、结构生物学家和生物物理学家 鼓励跨疾病和系统发育边界的新合作，并测试创新模型 未来，本次会议将成为面向全球受众的混合会议。