Frontiers in Fundamental and Translational Immunology

基础和转化免疫学前沿

• 批准号: 10318101
• 负责人: Linda Mac Pherson Bradley
• 金额: $ 14.93万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2023-06-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318101
• 关键词: Immunology; frontier

PROJECT SUMMARY This proposal seeks support to establish an innovative multi-thematic postdoctoral training program in fundamental and translational immunology to address the role of innate and adaptive immune cells in various disease contexts. Emphasis is placed on understanding the cellular and molecular basis of immune cell activation in the appropriate context of an immune response to infectious organisms and toxins, or the dysregulation that occurs in the context of chronic inflammation and autoimmunity. These fundamental insights provide the basis for novel therapeutic approaches in infectious disease, autoimmunity and cancer that will be tested in pre-clinical models. Sanford Burnham Prebys Medical Discovery Institute (SBP) recently implemented its 10-year strategic vision, which focuses on four disease priorities (cancer, autoimmunity, metabolic and neurological disorders) and four cross-cutting scientific themes including epigenetics, metabolism, proteostasis and immunomodulation. The proposed Program is an important element of this vision as we strive to provide the best training environment for postdoctoral scientists interested in immunology research. Scientific research at the Institute is supported by an infrastructure that includes multiple core facilities, thereby providing access to advanced technologies and expert, dedicated personnel. SBP emphasizes a collaborative approach to biomedical research, where teams of scientists with expertise in the biological sciences work together with chemists, structural biologists, engineers, and computational biologists to achieve synergistic accomplishments. This collaborative approach to science is intimately integrated into the culture of the Institute, as demonstrated by the fact that ~30% of all SBP publications are the result of inter- and intra- programmatic collaborations. Notably, 35% of over 500 publications from the preceptors' laboratories are led by postdoctoral trainees who serve as first authors. Postdoctoral trainees in this T32 will join one of 13 research groups focused on aspects of immunology. The trainees will be guided by mentoring committees focused on promoting scientific progress and career development. Seminar programs, workshops, retreats and journal clubs will enrich research training. The trainees will be selected based on scientific and academic accomplishments, suitability for research projects in the thematic areas and commitment to a scientific career that builds upon the postdoc experience. Trainees will be supported for an average of 2 years, but will remain with the program upon achieving independent support. The Program will support three trainees within the network of postdoctoral researchers at SBP. It is expected that matriculants who have completed this Program will have received a well-rounded training experience in cutting-edge patient-focused immunology research and will be well prepared to embark on a variety of independent research and research-related careers in fundamental and translational immunology.

项目摘要 该提案寻求支持，以建立一个创新的多主题博士后培训计划， 基础和翻译免疫学，以解决先天性和适应性免疫细胞在各种疾病中的作用。 疾病背景。重点放在了解免疫细胞的细胞和分子基础 在对感染性生物体和毒素的免疫应答的适当背景下激活，或 在慢性炎症和自身免疫的背景下发生的失调。这些基本的见解 为传染病、自身免疫和癌症的新治疗方法提供了基础， 在临床前模型中测试。Sanford Burnham Prebys医学发现研究所（SBP）最近实施了 其10年战略愿景，重点是四个疾病优先事项（癌症，自身免疫，代谢和 神经系统疾病）和四个交叉科学主题，包括表观遗传学、代谢、蛋白质稳态 和免疫调节。拟议的计划是这一愿景的重要组成部分，因为我们努力提供 对免疫学研究感兴趣的博士后科学家的最佳培训环境。科研 研究所的基础设施包括多个核心设施， 先进的技术和专业的、敬业的人才。战略和业务计划强调采取协作办法， 生物医学研究，具有生物科学专业知识的科学家团队与 化学家，结构生物学家，工程师和计算生物学家，以实现协同 成就。这种合作的科学方法是密切融入文化的 研究所，这一事实表明，约30%的SBP出版物是机构间和机构内的结果， 方案合作。值得注意的是，在导师实验室的500多篇出版物中， 由博士后实习生担任第一作者。博士后培训生在此T32将加入其中的13个 研究小组专注于免疫学方面。学员将由辅导委员会指导 着力推动科技进步和事业发展。研讨会计划，讲习班，务虚会和 期刊俱乐部将丰富研究培训。受训人员将根据科学和学术标准进行挑选。 成就，适合专题领域的研究项目和对科学事业的承诺 建立在博士后经验的基础上。受训人员将获得平均两年的支助，但将继续 在获得独立支持后，该计划将支持三名学员在 SBP的博士后研究人员网络。预计完成该计划的学生 将在以患者为中心的前沿免疫学研究方面获得全面的培训经验 并将做好充分准备，开始各种独立的研究和研究相关的职业生涯， 基础和转化免疫学。

项目成果

GLUT1 is a highly efficient L-fucose transporter.

• DOI: 10.1016/j.jbc.2022.102738
• 发表时间: 2023-01
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Ng, Bobby G.;Sosicka, Paulina;Xia, Zhijie;Freeze, Hudson H.
• 通讯作者: Freeze, Hudson H.

Homozygous truncating variant in MAN2A2 causes a novel congenital disorder of glycosylation with neurological involvement.

MAN2A2 中的纯合截短变异会导致一种新型先天性糖基化疾病，并累及神经系统。

• DOI: 10.1136/jmg-2022-108821
• 发表时间: 2023
• 期刊: Journal of medical genetics
• 影响因子: 4
• 作者: Mahajan,Sonal;Ng,BobbyGeorge;AlAbdi,Lama;Earnest,PaulDanielJames;Sosicka,Paulina;Patel,Nisha;Helaby,Rana;Abdulwahab,Firdous;He,Miao;Alkuraya,FowzanS;Freeze,HudsonH
• 通讯作者: Freeze,HudsonH