Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells
视网膜中的脂肪酸结合蛋白和内源性大麻素;
基本信息
- 批准号:10320023
- 负责人:
- 金额:$ 36.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-01 至 2025-11-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteBiological ModelsBiologyBirdsBloodCandidate Disease GeneCellsChickChick modelDataDegenerative DisorderDevelopmentDiseaseEndocannabinoidsEye diseasesFABP5 geneFailureFishesGene ExpressionGene Expression ProfileGlaucomaGoalsGrowth FactorInvestigationLinkMacular degenerationMammalsMetabolismMolecularMuller&aposs cellMusNatural regenerationNerve RegenerationNeurogliaNeuronsPathway interactionsPharmacologyPhenotypeProliferatingReporterReportingResearchResolutionRetinaRetinal DiseasesRetinitis PigmentosaRodent ModelRoleSignal PathwaySignal TransductionSourceStressTestingUp-RegulationVertebratesVisioncold blooded vertebratecomparativeendocannabinoid signalingexperimental studyfatty acid-binding proteinsgene networkgenetic approachhuman diseasein vivomouse modelneurogenesisneuron regenerationnovelnovel therapeuticsprogenitorprogramsregeneration potentialregenerativeretinal damageretinal neuronretinal progenitor cellretinal regenerationsight restorationsingle-cell RNA sequencingstem cellstranscriptomics
项目摘要
Project Summary: There is a rapidly growing body of evidence that Müller glia can are a source of retinal
progenitors to promote neural regeneration. Many studies have demonstrated that Müller glia can become
proliferating progenitor cells in the retinas of different vertebrate species. Most reports have studied Müller
glia-derived progenitors in acutely damaged retinas. However, little is known about the mechanisms that
stimulate neurogenesis from Müller glia-derived progenitors in undamaged retinas or retinas undergoing slow,
progressive degeneration. Furthermore, the regeneration of retinal neurons in warm-blooded vertebrates is
limited compared to that seen in cold-blooded vertebrates. Therefore, the identification of the secreted factors
and signaling pathways that block or stimulate neural regeneration from Müller glia-derived progenitors is
crucially important to developing new therapies to treat degenerative diseases of the human retina. We have
obtained compelling novel preliminary data indicating that Fatty acid-binding proteins (FABPs) and
endocannabinoids impact the de-differentation and reprogramming of Müller glia into proliferating, neurogenic
retinal progenitors in chicks and mice. We will investigate how the phenotype and plasticity of the Müller glia
are regulated by FABPs and endocannabinoids in normal, damaged and growth factor-treated retinas. We will
use a combination of pharmacological and genetic approaches to selectively activate or inhibit FABPs and
endocannabinoid-signaling. We will compare and contrast how FABPs and endocannabinoid-signaling impacts
the formation of Müller glia-derived progenitors in chick and rodent model systems with different inherent
capacities for retinal regeneration. We expect that the completion of the experiments described in this
proposal will provide significant new information regarding how mature Müller glia can be reprogrammed into
Müller glia-derived progenitors that regenerate retinal neurons. Identification and understanding of the
mechanisms that enhance the neurogenic potential of Müller glia is required to develop new therapies for sight-
threatening diseases, such as glaucoma, retinitis pigmentosa and macular degeneration that involve the loss of
retinal neurons.
项目总结:越来越多的证据表明,神经胶质细胞是视网膜的来源之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('ANDY J FISCHER', 18)}}的其他基金
Core A. Structural and Functional Assessments (SFA)
核心 A. 结构和功能评估 (SFA)
- 批准号:
10707326 - 财政年份:2022
- 资助金额:
$ 36.83万 - 项目类别:
Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells
视网膜中的脂肪酸结合蛋白和内源性大麻素;
- 批准号:
10094598 - 财政年份:2021
- 资助金额:
$ 36.83万 - 项目类别:
Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells
视网膜中的脂肪酸结合蛋白和内源性大麻素;
- 批准号:
10544488 - 财政年份:2021
- 资助金额:
$ 36.83万 - 项目类别:
Muller glia: roles in retinal homeostasis and neuronal regeneration
Muller 胶质细胞:在视网膜稳态和神经元再生中的作用
- 批准号:
8368871 - 财政年份:2012
- 资助金额:
$ 36.83万 - 项目类别:
Muller glia: roles in retinal homeostasis and neuronal regeneration
Muller 胶质细胞:在视网膜稳态和神经元再生中的作用
- 批准号:
8511663 - 财政年份:2012
- 资助金额:
$ 36.83万 - 项目类别:
Muller glia: roles in retinal homeostasis and neuronal regeneration
Muller 胶质细胞:在视网膜稳态和神经元再生中的作用
- 批准号:
9810726 - 财政年份:2012
- 资助金额:
$ 36.83万 - 项目类别:
Muller glia: roles in retinal homeostasis and neuronal regeneration
Muller 胶质细胞:在视网膜稳态和神经元再生中的作用
- 批准号:
10019557 - 财政年份:2012
- 资助金额:
$ 36.83万 - 项目类别:
Muller glia: roles in retinal homeostasis and neuronal regeneration
Muller 胶质细胞:在视网膜稳态和神经元再生中的作用
- 批准号:
10203990 - 财政年份:2012
- 资助金额:
$ 36.83万 - 项目类别:
Muller glia: roles in retinal homeostasis and neuronal regeneration
Muller 胶质细胞:在视网膜稳态和神经元再生中的作用
- 批准号:
8699779 - 财政年份:2012
- 资助金额:
$ 36.83万 - 项目类别:
Muller glia and neuronal regeneration in the retina
米勒神经胶质细胞和视网膜神经元再生
- 批准号:
7409563 - 财政年份:2006
- 资助金额:
$ 36.83万 - 项目类别:
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