Core A. Structural and Functional Assessments (SFA)

核心 A. 结构和功能评估 (SFA)

• 批准号: 10707326
• 负责人: ANDY J FISCHER
• 金额: $ 21.29万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707326
• 关键词: Agreement; Angiography; Animal Model; Arts; Blindness; Cell model; Cells; Clinical Research; Collaborations; Communities; Complex; Consultations; Data; Data Science; Educational Status; Electrophysiology (science); Eligibility Determination; Engineering; Ensure; Environment; Equipment; Experimental Designs; Eye diseases; Faculty; Faculty Recruitment; Fluorochrome; Funding; Fundus photography; Future; Goals; Grant; High Performance Computing; Image; Individual; Institution; Lasers; Leadership; Letters; Medicine; Microscope; Mission; Neurosciences; Ohio; Ophthalmology; Optometry; Outcome; Pediatric Hospitals; Pediatrics; Preparation; Proteins; Protocols documentation; Psychology; Quality Control; Research; Research Personnel; Research Project Grants; Reservations; Retina; Science; Scientist; Services; Specimen; Surveys; System; Technical Expertise; Testing; Training; Universities; Veterinary Medicine; Vision; Vision research; clinical translation; cluster computing; college; cost; data acquisition; design; equipment acquisition; experience; experimental study; high standard; image guided; instrument; manufacture; meetings; new technology; prevent; programs; sight restoration; structural imaging; supercomputer; synergism; tonometry; vision science

CORE A. STRUCTURAL AND FUNCTIONAL ASSESSMENTS (SFA) abstract The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP) has established scientific connections among the vision researchers across five academic units (i.e., College of Medicine (COM), College of Optometry (COO), College of Engineering, College of Veterinary Medicine, College of Arts and Sciences) and newly engaged Nationwide Children’s Hospital. Program Director (PD) Dr. Moroi has support and commitment from Deans and Chairs to purchase equipment (i.e., a new confocal microscope for Core A), support for data science needs, assigned space for three newly recruited faculty to Dept. Ophthalmology and Visual Sciences (DOVS), new and existing programs to enhance collaborations among NEI-funded PIs, and facilitate gathering pilot data for future PIs. Core A is called the Structural and Functional Assessments (SFA) Core and was determined from a survey administered to 61 OSU vision scientists who are NEI-funded Users and eligible investigators as unfunded Users. The leadership of Core A is Director Dr. Fischer, who has two NEI R01 grants and is an experienced retina cell biologist, and Co-director Dr. Cebulla, who has her first NEI R01 grant and is an outstanding retina clinician scientist. Core A’s purpose is to provide technical expertise and state-of-the-art and properly maintained equipment for imaging and functional assessment of fixed and living cells and for animal models. The equipment includes: (a) wide-field epifluorescence microscope, (b) confocal microscopes, (c) OCT, (d) tonometry, (e) Topcon fundus photography, angiography, and operating microscope, (f) electrophysiology equipment, and (g) a Micron IV ImageGuided Laser System. Successful implementation of Core A SFA will be conducted in the following two aims: Aim 1. To provide training and access to structural imaging equipment and functional testing equipment. Aim 2. To provide consultation and assistance with experiments. Another major added value is the ability to provide machine shop services. PD Dr. Moroi has arranged an agreement with The OSU Center for Design and Manufacturing Excellence (CDME) to provide faculty with new technologies and manufactured products to enhance funded research projects. CDME Executive Director Mr. Nate Ames has provided a letter of support and has indicated that meeting the vision scientist User needs aligns with the mission for CDME. This proposed P30 Core A, SFA, intends to maximize efficiency, offer centralized access to equipment and expertise that would be difficult, costly or impractical to duplicate in individual labs, and use protocols to ensure best practices to perform science at the highest standard. Credit to Core A Director Fischer and Co-director Cebulla for setting the collaborative culture of equipment sharing to enable initiating OSU-VSRCP. The expected outcome is increased collaboration for successful new proposals with the shared overarching goal to prevent blindness, restore vision and develop cures for eye diseases.

核心A.结构和功能评估（SFA）摘要 俄亥俄州立大学愿景科学研究核心计划（OSU-VSRCP）已经建立了科学 跨五个学术单位的远见研究人员之间的联系（即医学院（COM）， 验光学院（COO），工程学院，兽医学院，艺术学院和 科学）和新订婚的全国儿童医院。计划总监（PD）Moroi博士有支持 以及院长和椅子购买设备的承诺（即，核心A的新共聚焦显微镜）， 支持数据科学需求，为三个新招募的教职员工分配空间 视觉科学（DOV），新的和现有的计划，以增强Nei资助的PI之间的合作以及 促进将未来PI的试点数据收集。核心称为结构和功能评估 （SFA）核心，并根据对61位OSU视觉科学家进行的调查确定 用户和符合条件的调查人员是无资金的用户。核心A的领导是菲舍尔博士，他 两项NEI R01赠款，是一位经验丰富的视网膜细胞生物学家，塞布拉（Cebulla）博士，她是她的第一个 NEI R01 Grant是一位杰出的视网膜临床科学家。核心A的目的是提供技术 专业知识，最先进的以及适当维护的设备，用于成像和功能评估 固定和活细胞以及动物模型。设备包括：（a）宽场落荧光 显微镜，（b）共聚焦显微镜，（c）OCT，（d）TONOMETIRE，（e）Topcon底部摄影，血管造影，血管造影， 和操作显微镜，（F）电生理设备，以及（g）微米IV Imagegued激光系统。 在以下两个目的中，将成功实施核心A SFA：目标1。 培训和使用结构成像设备和功能测试设备。目标2 为实验提供咨询和协助。另一个主要的附加值是提供 机械车间服务。 PD Moroi博士已与OSU设计中心安排了一项协议， 卓越制造业（CDME）为教师提供新技术和制造产品 增强的研究项目。 CDME执行董事Nate Ames先生提供了一封信 支持，并表明与愿景科学家用户满足需要与CDME的任务保持一致。 该拟议的P30核A，SFA打算最大化效率，提供集中的设备访问权限和 在单个实验室中复制并使用协议来确保的专业知识将是困难，昂贵或不切实际的 以最高标准执行科学的最佳实践。核心核心董事菲舍尔和联合导演 Cebulla设置设备共享的协作文化，以启动OSU-VSRCP。这 预期的结果是通过共享总体目标的成功新提案的合作增加 为了防止失明，恢复视力并为眼部疾病发展治愈。