Core A. Structural and Functional Assessments (SFA)

核心A.结构和功能评估(SFA)摘要 俄亥俄州立大学视觉科学研究核心计划(OSU-VSRCP)已经建立了科学 视觉研究人员在五个学术单位(即，医学院(COM)， 验光学院(COO)，工程学院，兽医学院，艺术和 科学)和新加入的全国儿童医院。项目主管(PD)Moroi博士表示支持 以及院长和教席对购买设备的承诺(即为A芯购买新的共焦显微镜)， 支持数据科学的需求，为三名新招聘的教职员工分配了空间。眼科和眼科 视觉科学(DOVS)，新的和现有的计划，以加强NEI资助的PI之间的合作，以及 促进为未来的PI收集试点数据。核心A称为结构和功能评估 (SFA)Core，这是通过对61名由NEI资助的俄亥俄州立大学视觉科学家进行的调查确定的 用户和符合条件的调查人员被视为无资金用户。核心A的领导层是主任费舍尔博士，他有 两位NEI R01获奖者，是一位经验丰富的视网膜细胞生物学家，以及第一位获得 NEI R01获奖，是一位杰出的视网膜临床科学家。核心A的目的是提供技术支持 用于成像和功能评估的专业知识、最先进的和适当维护的设备 固定细胞和活细胞以及动物模型。该设备包括：(A)广场荧光 显微镜，(B)共焦显微镜，(C)OCT，(D)眼压计，(E)Topcon眼底照相，血管造影术， 和手术显微镜，(F)电生理设备，和(G)一个Micron IV图像引导激光系统。 将在以下两个目标下成功实施核心A SFA：目标1.提供 培训和接触结构成像设备和功能测试设备。目标2.目标 提供实验咨询和帮助。另一个主要的附加值是能够提供 机械修理店服务。帕特里克·莫罗伊博士已与俄亥俄州立大学设计中心达成协议 卓越制造(CDME)为教师提供新技术和制造产品，以 加强资助研究项目。CDME执行董事Nate Ames先生提供了一封 支持并表示，满足视觉科学家的用户需求与CDME的使命一致。 建议的P30核心A(SFA)旨在最大限度地提高效率，提供对设备的集中访问，并 在单个实验室中复制将是困难、昂贵或不切实际的专业知识，并使用协议来确保 以最高标准开展科学研究的最佳实践。归功于核心A董事费舍尔和联席董事 CeBulla用于建立设备共享的协作文化，以启动OSU-VSRCP。这个 预期结果是为成功的新提案增加协作，实现共同的总体目标 预防失明，恢复视力，开发治疗眼病的方法。

CORE A. STRUCTURAL AND FUNCTIONAL ASSESSMENTS (SFA) abstract The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP) has established scientific connections among the vision researchers across five academic units (i.e., College of Medicine (COM), College of Optometry (COO), College of Engineering, College of Veterinary Medicine, College of Arts and Sciences) and newly engaged Nationwide Children’s Hospital. Program Director (PD) Dr. Moroi has support and commitment from Deans and Chairs to purchase equipment (i.e., a new confocal microscope for Core A), support for data science needs, assigned space for three newly recruited faculty to Dept. Ophthalmology and Visual Sciences (DOVS), new and existing programs to enhance collaborations among NEI-funded PIs, and facilitate gathering pilot data for future PIs. Core A is called the Structural and Functional Assessments (SFA) Core and was determined from a survey administered to 61 OSU vision scientists who are NEI-funded Users and eligible investigators as unfunded Users. The leadership of Core A is Director Dr. Fischer, who has two NEI R01 grants and is an experienced retina cell biologist, and Co-director Dr. Cebulla, who has her first NEI R01 grant and is an outstanding retina clinician scientist. Core A’s purpose is to provide technical expertise and state-of-the-art and properly maintained equipment for imaging and functional assessment of fixed and living cells and for animal models. The equipment includes: (a) wide-field epifluorescence microscope, (b) confocal microscopes, (c) OCT, (d) tonometry, (e) Topcon fundus photography, angiography, and operating microscope, (f) electrophysiology equipment, and (g) a Micron IV ImageGuided Laser System. Successful implementation of Core A SFA will be conducted in the following two aims: Aim 1. To provide training and access to structural imaging equipment and functional testing equipment. Aim 2. To provide consultation and assistance with experiments. Another major added value is the ability to provide machine shop services. PD Dr. Moroi has arranged an agreement with The OSU Center for Design and Manufacturing Excellence (CDME) to provide faculty with new technologies and manufactured products to enhance funded research projects. CDME Executive Director Mr. Nate Ames has provided a letter of support and has indicated that meeting the vision scientist User needs aligns with the mission for CDME. This proposed P30 Core A, SFA, intends to maximize efficiency, offer centralized access to equipment and expertise that would be difficult, costly or impractical to duplicate in individual labs, and use protocols to ensure best practices to perform science at the highest standard. Credit to Core A Director Fischer and Co-director Cebulla for setting the collaborative culture of equipment sharing to enable initiating OSU-VSRCP. The expected outcome is increased collaboration for successful new proposals with the shared overarching goal to prevent blindness, restore vision and develop cures for eye diseases.