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Development and Sex Differentiation of Context Fear Neural Circuits

情境恐惧神经回路的发育和性别分化

基本信息

批准号：
10319976
负责人：
ANDREW M POULOS
金额：
$ 37.85万
依托单位：
STATE UNIVERSITY OF NEW YORK AT ALBANY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10319976
关键词：
ARHGEF5 gene Adolescence Adolescent Adult Affective Age Amygdaloid structure Animal Model Animals Anxiety Anxiety Disorders Architecture Behavior Behavioral Mechanisms Brain Brain region Castration Child Childhood Clinical Cognitive Colon Complex Dangerousness Data Databases Deep Brain Stimulation Development Education Elements Emotional Environment Estrus Exhibits Female Freezing Fright Funding Gonadal Hormones Growth Hippocampus (Brain)Hybrids Immunohistochemistry Infant Knowledge Lead Learning Literature Longevity Maps Medial Memory Mental Health Methods Mission Modeling Neonatal Neural Pathways Neuroanatomy Neurons Neurosciences Pathway interactions Pattern Perceptual learning Perinatal Population Post-Traumatic Stress Disorders Procedures Rattus Risk Factors Role Running Sex Differentiation Shapes System Testing Testosterone Time United States National Institutes of Health Woman base childhood adversity classical conditioning cognitive function cognitive system conditioned fear conditioning connectome fear memory functional status infancy juvenile animal learned behavior male mature animal neural circuit neuromechanism novel postnatal development preadolescence recruit relating to nervous system sex sexual dimorphism tool

项目摘要

Understanding the post-natal emergence and progression of episodic/hippocampal based and affective/amygdala based learning and memory systems in male and female animals can lead to significant advances in education, anxiety disoders and a detailed understanding of neural basis of learning and memory. We start off with the basic observation that learning and memory in children and young animals are particulary distinct when compared to adult mammalian counterparts. Our central hypothesis is that early in development, affective neural circuits dominate learning and that later, cognitive neural circuits emerge to further regulate learned behaviors. Moreover, the development and function of each these memory systems are influenced by perinatal gonadal hormones, resulting in sex differentiation of learning and memory. This hypothesis is grounded in the knowledge that late maturing hippocampal and prefrontal cortical circuits are fine-tuned to encode patterns of contextual-spatial elements and at test are capable to sufficiently retrieve this same pattern of elements.This pattern completion view of perceptual learning is combined with the knowledge that the basolateral and central amygdala microcircuits emerge earlier in development and are crucial for emotional learning including fear. We approach these questions by using standard and modified Contextual Fear Conditioning procedures in combination with neuroanatomical tools to create whole-brain functional neural acitivity maps underlying learning and memory across developmental lifespan of the male and female rat. These data will be used to create an open access database of all raw data, functional maps and group analytics. In addition, these data will be used to target inactivation of key neural pathways in the acquisition, retention and retriveal of contextual fear memories.

了解出生后偶发性/海马性脑卒中的出现和发展