Channel structure-based tools for precise interrogation of circuitry and behavior

基于通道结构的工具，用于精确询问电路和行为

• 批准号: 10319554
• 负责人: Karl A. Deisseroth
• 金额: $ 80.22万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-12 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10319554
• 关键词: Affinity; Algae; Amino Acids; Animals; Anxiety; Behavior; Behavioral; Binding; Binding Sites; Brain; Brain region; Cations; Cells; Chlorides; Closure by clamp; Color; Crystallization; Data; Data Set; Detection; Development; Dimensions; Disease; Distant; Electroencephalography; Electrostatics; Elements; Engineering; Environment; Foundations; Fright; Functional Magnetic Resonance Imaging; Funding; Generations; Genomics; Goals; Grant; Image; Integral Membrane Protein; Ion Pumps; Ions; Light; Literature; Mammals; Mental disorders; Methods; Modeling; Molecular; Molecular Structure; Mutation; Nature; Neurosciences; Opsin; Optics; Paper; Pattern; Photons; Polyenes; Positioning Attribute; Positron-Emission Tomography; Property; Proteins; Publishing; Pump; Reporting; Research; Resistance; Resolution; Retina; Science; Side; Structure; Surface; Technology; Testing; Tissues; Triplet Multiple Birth; Variant; Viral Vector; Work; X-Ray Crystallography; anxiety-related behavior; base; design; experimental study; insight; mind control; neural circuit; novel; optogenetics; prevent; redshift; tool; voltage

No abstract provided

未提供摘要

项目成果

Leptin regulates the reward value of nutrient.

• DOI: 10.1038/nn.2977
• 发表时间: 2011-11-13
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Domingos AI;Vaynshteyn J;Voss HU;Ren X;Gradinaru V;Zang F;Deisseroth K;de Araujo IE;Friedman J
• 通讯作者: Friedman J

Crystal structure of the natural anion-conducting channelrhodopsin GtACR1.

• DOI: 10.1038/s41586-018-0511-6
• 发表时间: 2018-09
• 期刊: Nature
• 影响因子: 64.8
• 作者: Kim YS;Kato HE;Yamashita K;Ito S;Inoue K;Ramakrishnan C;Fenno LE;Evans KE;Paggi JM;Dror RO;Kandori H;Kobilka BK;Deisseroth K
• 通讯作者: Deisseroth K

Structural mechanisms of selectivity and gating in anion channelrhodopsins.

• DOI: 10.1038/s41586-018-0504-5
• 发表时间: 2018-09
• 期刊: Nature
• 影响因子: 64.8
• 作者: Kato HE;Kim YS;Paggi JM;Evans KE;Allen WE;Richardson C;Inoue K;Ito S;Ramakrishnan C;Fenno LE;Yamashita K;Hilger D;Lee SY;Berndt A;Shen K;Kandori H;Dror RO;Kobilka BK;Deisseroth K
• 通讯作者: Deisseroth K