Research Project 1 - Developing and applying tools to probe internal state dynamics of perception and motivation
研究项目 1 - 开发和应用工具来探测感知和动机的内部状态动态
基本信息
- 批准号:10047732
- 负责人:
- 金额:$ 43.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-17 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAnimal BehaviorAreaBehaviorBehavioralBehavioral ModelBiologicalBrainBrain regionCaliberCell NucleusCellsCommunitiesComplexDataData SetDevelopmentDimensionsDoctor of PhilosophyEducation and OutreachEnsureEventFire - disastersGene ExpressionIndividualLaboratoriesLeadLearningLinkMeasuresMethodsMissionModelingMolecularMotivationMusNeuromodulatorNeuronsNoiseOutputPatternPerceptionPlayPopulation DynamicsPositioning AttributePreparationPrimatesProbabilityPropertyPupilReaction TimeResearch Project GrantsResolutionRodentRoleSatiationSensorySignal TransductionSourceSpecific qualifier valueSpeedStimulusStructureTechnologyTestingTextThirstTimeTrainingTypologyVisual PerceptionWorkWritingalertnessarea striatabasecell typedata modelingdesignexperimental studyinterestmolecular phenotypenetwork modelsnonhuman primateoptogeneticsrelating to nervous systemsensory cortexsensory inputtheoriestoolvigilancevisual stimulus
项目摘要
Research Project 1 - Internal state dynamics of perception and motivati0n
Lead: Karl Deisseroth MD PhD
Summary
This project is focused on development and application of technology for probing the interaction of external
sensory input with internal states of the mammalian brain. The unique leverage of our team is technology-driven
experimental access to new regimes of speed, scope, and resolution in defining and tuning these internal states.
First, we will quantify the population dynamics and statistical structure of time-varying spontaneous activity
across the volume of primary visual cortex (with individual cells defined by position and wiring in 3D space, and
by molecular identity) to test impact of spontaneous fluctuations on environmental stimulus-triggered neuronal
activity and animal behavior. Next, we will quantify cortical activity during transitions among internal states
(along with behaviors), impose precisely-defined ensemble activity to assess impact of state transitions on
evoked population dynamics and behavior, and quantify endogenous activity influencing these states to assess
natural mechanisms and effects. Finally, we will integrate our biological findings and new technological
capabilities to directly and precisely impose more complex temporal dynamics of interest by controlling multiple
single cells in multiple cortical regions over time. The same cells observed to be active and important in behavior
will be made available for molecular phenotyping analysis, so that cell typology may be linked to the specific
natural and causal roles of cells in this important domain of circuit computation and behavior.
研究项目1 -感知和动机的内部状态动力学
负责人:Karl Deisseroth MD PhD
总结
该项目的重点是开发和应用技术,以探索外部环境的相互作用。
感觉输入与哺乳动物大脑的内部状态。我们团队的独特优势是技术驱动
在定义和调整这些内部状态时,实验性地获得新的速度、范围和分辨率。
首先,我们将量化随时间变化的自发活动的种群动力学和统计结构
跨初级视觉皮层的体积(具有由3D空间中的位置和布线定义的单个细胞,以及
以测试自发波动对环境刺激触发的神经元的影响
活动和动物行为。接下来,我们将量化在内部状态之间转换期间的皮质活动
(沿着行为),施加精确定义的集成活动,以评估状态转换对
诱发种群动态和行为,并量化影响这些状态的内源性活动,以评估
自然机制和效果。最后,我们将把我们的生物学发现和新技术结合起来,
能够通过控制多个时间动态来直接和精确地施加感兴趣的更复杂的时间动态,
单个细胞在多个皮层区域的生长。同样的细胞被观察到在行为中是活跃和重要的
将可用于分子表型分析,以便细胞类型学可以与特定的
细胞在电路计算和行为的这个重要领域中的自然和因果作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Karl A. Deisseroth其他文献
Karl A. Deisseroth的其他文献
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{{ truncateString('Karl A. Deisseroth', 18)}}的其他基金
An optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primates
用于监测和控制灵长类动物复杂行为的多种神经调节回路的光遗传工具箱
- 批准号:
10650669 - 财政年份:2023
- 资助金额:
$ 43.51万 - 项目类别:
Interaction of external inputs with internal dynamics: influence of brain states on neural computation and behavior
外部输入与内部动态的相互作用:大脑状态对神经计算和行为的影响
- 批准号:
10698364 - 财政年份:2021
- 资助金额:
$ 43.51万 - 项目类别:
Interaction of external inputs with internal dynamics: influence of brain states on neural computation and behavior
外部输入与内部动态的相互作用:大脑状态对神经计算和行为的影响
- 批准号:
10047726 - 财政年份:2021
- 资助金额:
$ 43.51万 - 项目类别:
Research Project 1 - Developing and applying tools to probe internal state dynamics of perception and motivation
研究项目 1 - 开发和应用工具来探测感知和动机的内部状态动态
- 批准号:
10490239 - 财政年份:2021
- 资助金额:
$ 43.51万 - 项目类别:
Research Project 1 - Developing and applying tools to probe internal state dynamics of perception and motivation
研究项目 1 - 开发和应用工具来探测感知和动机的内部状态动态
- 批准号:
10687144 - 财政年份:2021
- 资助金额:
$ 43.51万 - 项目类别:
Interaction of external inputs with internal dynamics: influence of brain states on neural computation and behavior
外部输入与内部动态的相互作用:大脑状态对神经计算和行为的影响
- 批准号:
10687134 - 财政年份:2021
- 资助金额:
$ 43.51万 - 项目类别:
Interaction of external inputs with internal dynamics: influence of brain states on neural computation and behavior
外部输入与内部动态的相互作用:大脑状态对神经计算和行为的影响
- 批准号:
10490233 - 财政年份:2021
- 资助金额:
$ 43.51万 - 项目类别:
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