Biobehavioral Factors and their Impact on Stress-Related Eating in Obesity

生物行为因素及其对肥胖者压力相关饮食的影响

• 批准号: 10336861
• 负责人: SCOTT G ENGEL
• 金额: $ 72.96万
• 依托单位: SANFORD RESEARCH NORTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10336861
• 关键词: Affect; American; Behavior assessment; Behavioral; Binge Eating; Biological; Biological Factors; Body Weight decreased; Brain; Calories; Carbohydrates; Complex; Consumption; Data; Data Collection; Data Reporting; Dietary intake; Eating; Eating Behavior; Economics; Energy Intake; Exhibits; Fatty acid glycerol esters; Feeding behaviors; Food; Food Selections; Genes; Health; Human; Hydrocortisone; Hyperphagia; Individual; Intake; Intervention; Investigation; Knowledge; Laboratories; Lead; Link; Mental Health; Methodology; Methods; Modeling; Negative Reinforcements; Obesity; Obesity Epidemic; Overweight; Participant; Patient Self-Report; Pattern; Physiological; Population; Prevention; Process; Quality of life; Research; Rewards; Risk; Role; Stress; Techniques; Testing; Time; United States; Weight Gain; base; biobehavior; dietary; experience; food consumption; gut microbiome; gut microbiota; high reward; indexing; microbiome; microbiota; novel; obese person; obesity prevention; perceived stress; personalized medicine; physical conditioning; prevent; prospective; psychologic; psychological stressor; response; stress reactivity; stressor; therapy development; trait

PROJECT SUMMARY/ABSTRACT Elucidating the biobehavioral factors that lead to problematic eating, and ultimately increase the risk for weight gain, is critically needed given the epidemic of obesity in the United States. While the relationship between stress and problematic eating has been well-established, other factors that impact this association remain poorly understood. One important variable that appears to impact the stress-eating relationship is the manner in which one responds to stressful situations. Stress reactivity is commonly assessed by the manner in which cortisol changes in response to a stressor. For those who tend to be highly reactive to stress, in moments of high stress, they appear to be more likely to overeat. Evidence suggests that the gut microbiota influences stress reactivity, and this appears to be an important biological factor that influences the stress-eating relationship. Additionally, individuals who place a high reward value on food may be more impacted in moments of stress and may ultimately overeat or make problematic food choices in those instances. In this study, we propose to pair biological and behavioral assessment to examine the novel Biobehavioral Model of Stress-Related Eating. Through a combined laboratory and naturalistic approach, we will investigate the extent to which specific taxa and genes of the gut microbiota, stress reactivity, and the reward value of food moderate the stress-eating relationship. Through this multi-method approach, we will also use a combination of momentary and daily assessment to collect real-time data on stress and its association with dietary intake. This study will overcome limitations of prior research through its use of momentary data collection and novel pairing of biological and behavioral variables. Elucidating key factors that lead to problematic eating in moments of high stress has the potential to lead to personalized treatment approaches for weight reduction and the prevention of obesity.

项目摘要/摘要 阐明导致问题饮食的生物行为因素，并最终增加体重的风险 考虑到美国肥胖症的流行，这是非常必要的。虽然， 压力和饮食问题已经得到了很好的证实，其他影响这种联系的因素仍然很差 明白一个影响压力和进食关系的重要变量是， 一个人会对压力做出反应应激反应通常是通过皮质醇 对压力的反应。对于那些对压力反应强烈的人来说，在压力很大的时候， 他们似乎更有可能吃得过多。有证据表明，肠道微生物群影响应激反应， 这似乎是一个重要的生物因素，影响压力和进食的关系。此外，本发明还 对食物给予高奖励价值的人在压力时刻可能受到更大的影响， 在这些情况下，最终会吃得过多或做出有问题的食物选择。在这项研究中，我们建议对 生物和行为评估，以检查新的压力相关饮食的生物行为模型。 通过实验室和自然主义相结合的方法，我们将调查特定类群在多大程度上 肠道微生物群的基因、应激反应和食物的奖励值调节了应激性进食 关系通过这种多方法的方式，我们也会采用瞬间和日常相结合的方式 评估，以收集有关压力及其与饮食摄入量的关联的实时数据。这项研究将克服 通过使用瞬时数据收集和生物学和生物学的新配对， 行为变量阐明导致高压力下饮食问题的关键因素， 有可能导致减肥和预防肥胖的个性化治疗方法。