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Biobehavioral Factors and their Impact on Stress-Related Eating in Obesity

生物行为因素及其对肥胖者压力相关饮食的影响

基本信息

批准号：
10490390
负责人：
SCOTT G ENGEL
金额：
$ 68.9万
依托单位：
SANFORD RESEARCH NORTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-21 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10490390
关键词：
Affect American Behavior assessment Behavioral Binge Eating Biological Biological Factors Body Weight decreased Brain Calories Carbohydrates Complex Consumption Data Data Collection Data Reporting Dietary intake Eating Eating Behavior Economics Energy Intake Exhibits Fatty acid glycerol esters Feeding behaviors Food Food Selections Genes Health Human Hydrocortisone Hyperphagia Individual Intake Intervention Investigation Knowledge Laboratories Lead Link Mental Health Methodology Methods Modeling Negative Reinforcements Obesity Obesity Epidemic Overweight Participant Patient Self-Report Pattern Physiological Population Prevention Process Quality of life Research Rewards Risk Role Stress Techniques Testing Time United States Weight Gain base biobehavior dietary experience food consumption gut microbiome gut microbiota high reward indexing microbiome microbiota novel obese person obesity prevention perceived stress personalized medicine physical conditioning prevent prospective psychologic psychological stressor response stress reactivity stressor therapy development trait

项目摘要

PROJECT SUMMARY/ABSTRACT Elucidating the biobehavioral factors that lead to problematic eating, and ultimately increase the risk for weight gain, is critically needed given the epidemic of obesity in the United States. While the relationship between stress and problematic eating has been well-established, other factors that impact this association remain poorly understood. One important variable that appears to impact the stress-eating relationship is the manner in which one responds to stressful situations. Stress reactivity is commonly assessed by the manner in which cortisol changes in response to a stressor. For those who tend to be highly reactive to stress, in moments of high stress, they appear to be more likely to overeat. Evidence suggests that the gut microbiota influences stress reactivity, and this appears to be an important biological factor that influences the stress-eating relationship. Additionally, individuals who place a high reward value on food may be more impacted in moments of stress and may ultimately overeat or make problematic food choices in those instances. In this study, we propose to pair biological and behavioral assessment to examine the novel Biobehavioral Model of Stress-Related Eating. Through a combined laboratory and naturalistic approach, we will investigate the extent to which specific taxa and genes of the gut microbiota, stress reactivity, and the reward value of food moderate the stress-eating relationship. Through this multi-method approach, we will also use a combination of momentary and daily assessment to collect real-time data on stress and its association with dietary intake. This study will overcome limitations of prior research through its use of momentary data collection and novel pairing of biological and behavioral variables. Elucidating key factors that lead to problematic eating in moments of high stress has the potential to lead to personalized treatment approaches for weight reduction and the prevention of obesity.

项目总结/文摘