Admin-Core-001

国际淋球菌疫苗发现、制剂和 实施（ICGV）是利用我们建立的疫苗抗原发现管道，以优化 我们选择的外膜蛋白抗原的抗原特性作为可能的疫苗组分。 此外，我们的中心将利用抗原多样性、全球菌株异质性和公众接受度 信息来生成改进的计算机模型，使我们能够预测任何非政府组织疫苗的成功 部署。本文档中描述的支持项目和核心取得成功的基础架构和协作 中心已经到位。行政核心的目标是确保ICGV在其 我们的目标是合理设计我们选择的Ngo外膜蛋白抗原， 预测建模方法，将序列和菌株多样性与公众对STI疫苗的意见相结合。 行政核心由项目和核心领导以及核心管理员组成， 将由一个由著名疫苗专家组成的小组作为外部科学咨询委员会予以补充。的 行政核心的具体目标如下：目标1。提供协调、监督和 简化中心活动监督的管理，同时激励协同和创造性 实现项目里程碑和目标的方法。目标2.协调以下各方的监管职责 中心，包括人类受试者、动物受试者、培训、依从性和NIH相关活动，包括 编制进度报告。目标3：促进与其他核心的协作，包括规划和支持 多中心会议。目标4。作为项目、核心、科学咨询委员会、 CRC执行委员会和NIH/NIAID工作人员。目标5。制定现实的时间表并监测进展情况 实现这些目标。必要时，将实施替代战略以达到项目 里程碑目标6。对所有项目和核心进行财务监督。目标7。提供一个环境 有利于核心和项目研究者之间的合作，确保研究者获得 对他们在这个复杂的团队项目中所做的贡献给予适当的认可。目标8。贯彻 发展和研究计划（DRP），以允许竞争性的应用程序，将确定 有前途的年轻研究人员并资助他们基于非政府组织的疫苗开发项目，这些项目最终将为 我们的生产线和模型。行政核心的创新方面包括： 主要研究者以及主要研究者与项目/核心负责人的良好合作;疫苗的既定渠道 抗原发现;整合和部署外部科学咨询委员会;以及 研究办公室承诺的发展和研究计划的补充资金， 弗吉尼亚联邦大学的创新。

The overall goal of the International Center for Gonococcal Vaccine Discovery, Formulation and Implementation (ICGV) is to employ our established pipeline for vaccine antigen discovery to optimize the antigenic properties of our selected outer membrane protein antigens as possible vaccine components. Furthermore, our Center will utilize antigen diversity, global strain heterogeneity, and public acceptance information to generate improved computer models that allow us to predict the success of any Ngo vaccine deployed. The infrastructure and collaborations to enable success for projects and cores described in this Center are already in place. The goal of the Administrative Core is to ensure that the ICGV is productive in its goals towards rational engineering of our selected Ngo outer membrane protein antigens and deploying predictive modeling approaches to integrate sequence and strain diversity with public opinion on STI vaccines. The Administrative Core consists of the project and core leadership and a Core Administrator, and this group will be supplemented by a panel of renowned vaccine experts as an external Scientific Advisory Board. The specific aims of the Administrative Core are as follows: Aim 1. Provide coordination, supervision and management that streamlines oversight of Center activities, while incentivizing synergistic and creative approaches to achieving project milestones and objectives. Aim 2. Coordinate regulatory responsibilities of the Center, including human subjects, animal subjects, training, compliance and NIH-related activities including production of progress reports. Aim 3. Foster collaboration with other cores, including planning and supporting multi-Center meetings. Aim 4. Function as an interface between projects, cores, the Scientific Advisory Board, CRC executive committee and NIH/NIAID staff. Aim 5. Establish realistic timelines and monitor progress towards these goals. When necessary, alternative strategies will be implemented to reach the project milestones. Aim 6. Provide financial oversight of all projects and cores. Aim 7. Provide an environment conducive to collaboration among the Core and Project investigators, ensuring investigators receive appropriate recognition for their contributions to this complex team-based project. Aim 8. Implement the Development and Research Program (DRP) to permit a competitive application process that will identify promising young investigators and fund their Ngo-based vaccine development projects that will ultimately feed into our pipeline and modeling. Innovative aspects of the Administrative Core include: the highly experienced PI and the well-established collaborations of PI with the project/core leads; the established pipeline for vaccine antigen discovery; the integration and deployment of an external Scientific Advisory Board; and the supplemental funding for the Development and Research Program committed by the Office of Research and Innovation at Virginia Commonwealth University.