Core-001
Core-001
批准号:
10330125
负责人:
CYNTHIA N CORNELISSEN
金额:
$2.75万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-03-25 至 2024-02-29
关键词:
Antigen TargetingAntigensBacteriaBacterial AdhesinsBacterial Attachment SiteBase SequenceBinding ProteinsBioinformaticsBloodCellsComplementComplement Factor HCore ProteinDataData ProtectionDetectionDevelopmentDiseaseEngineeringEnzyme-Linked Immunosorbent AssayEpidemiologyEpithelialFemaleGonorrheaHerd ImmunityHumanImmuneImmune responseImmunityImmunizationImmunologicsImmunologyIn VitroIndividualInfectionIronIron-Binding ProteinsLactoferrinLeukocyte L1 Antigen ComplexLibrariesMeasuresMediatingMembrane ProteinsModelingMucous MembraneMusNeisseria gonorrhoeaeNutrientPathway interactionsPelvic Inflammatory DiseasePopulationProteinsS100A7SiteSourceStructureTestingTissuesTransferrinTransgenic MiceTreesUrethraVaccine DesignVaccinesVariantZincbactericidebasecomplement 4b-binding proteincross reactivitydesignepidemiological modelhumanized mouseimmunogenicityinnovationmalemathematical modelmouse modelpathogenprotective efficacyreproductive tracttooltransmission processvaccine developmentvaccine efficacyvaccine evaluation
中文摘要
这一核心组件将利用我们建立的疫苗评估渠道,其中包括我们的
创新的高通量方法有助于我们的抗原工程工作,同时允许
抗血清对给定蛋白质的所有已知抗原变体的反应性,以及我们的
人性化的基于老鼠的感染模型,使我们能够测试疫苗在
淋球菌无症状定植和疾病。这个核心产生的结果是疫苗的核心
项目1和项目2正在进行设计和配方工作,并将用于为疫苗提供信息
正在项目3中执行影响建模。
英文摘要
This Core component will take advantage of our established vaccine evaluation pipeline, which includes our
innovative high throughput approaches facilitate our antigen engineering efforts by simultaneously allowing the
reactivity of antiserum to be measured against all known antigenic variants of a given protein, and our
humanized mouse-based infection models, which allow us to test the protective efficacy of vaccines during
gonococcal asymptomatic colonization and disease. The results generated by this Core are central to vaccine
design and formulation efforts being undertaken in Projects 1 and 2, and will be used to inform the vaccine
impact modeling being performed in Project 3.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
-
批准号:10595567
-
项目类别:
-
资助金额:$180.83万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Rational design of transferrin binding protein-based vaccines to combat gonorrhea
-
批准号:9888316
-
项目类别:
-
资助金额:$62.67万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
-
批准号:10355467
-
项目类别:
-
资助金额:$180.61万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Project-003
-
批准号:10330128
-
项目类别:
-
资助金额:$27.71万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Project-002
-
批准号:10330127
-
项目类别:
-
资助金额:$10.05万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Administrative Core
-
批准号:10595568
-
项目类别:
-
资助金额:$86.64万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Using gonococcal TonB-dependent transporters as vaccine antigens
-
批准号:10560825
-
项目类别:
-
资助金额:$42.34万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Rational design of transferrin binding protein-based vaccines to combat gonorrhea
-
批准号:10088372
-
项目类别:
-
资助金额:$62.8万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
ConProject-005
-
批准号:10311807
-
项目类别:
-
资助金额:$8.83万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Core-002
-
批准号:10330126
-
项目类别:
-
资助金额:$8.29万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
-
批准号:10116966
-
项目类别:
-
资助金额:$186.65万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
-
批准号:9899916
-
项目类别:
-
资助金额:$181.98万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Admin-Core-001
-
批准号:10330124
-
项目类别:
-
资助金额:$48.53万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
ConProject-006
-
批准号:10311808
-
项目类别:
-
资助金额:$9.95万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Using gonococcal TonB-dependent transporters as vaccine antigens
-
批准号:10595578
-
项目类别:
-
资助金额:$60.59万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Administrative Core
-
批准号:10355468
-
项目类别:
-
资助金额:$33.41万
-
财政年份:2019
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Neisseria gonorrhoeae metal transporters that subvert nutritional immunity
-
批准号:10585577
-
项目类别:
-
资助金额:$81.64万
-
财政年份:2017
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Neisseria gonorrhoeae metal transporters that subvert nutritional immunity
-
批准号:9218801
-
项目类别:
-
资助金额:$66.27万
-
财政年份:2017
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Neisseria gonorrhoeae metal transporters that subvert nutritional immunity
-
批准号:10707199
-
项目类别:
-
资助金额:$78.93万
-
财政年份:2017
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
Administrative Diversity Supplement for Aimee Potter
-
批准号:10818164
-
项目类别:
-
资助金额:$13.7万
-
财政年份:2017
-
负责人:CYNTHIA N CORNELISSEN
-
依托单位:
国内基金
海外基金
Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
-
批准号:2022J011295
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:王亚伟
-
依托单位:
结核分枝杆菌持续感染期抗原(latency antigens)的重组BCG疫苗研究
-
批准号:30801055
-
项目类别:青年科学基金项目
-
资助金额:19.0万元
-
批准年份:2008
-
负责人:王丽梅
-
依托单位: