Core-001
核心001
基本信息
- 批准号:10330125
- 负责人:
- 金额:$ 2.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-03-25 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:Antigen TargetingAntigensBacteriaBacterial AdhesinsBacterial Attachment SiteBase SequenceBinding ProteinsBioinformaticsBloodCellsComplementComplement Factor HCore ProteinDataData ProtectionDetectionDevelopmentDiseaseEngineeringEnzyme-Linked Immunosorbent AssayEpidemiologyEpithelialFemaleGonorrheaHerd ImmunityHumanImmuneImmune responseImmunityImmunizationImmunologicsImmunologyIn VitroIndividualInfectionIronIron-Binding ProteinsLactoferrinLeukocyte L1 Antigen ComplexLibrariesMeasuresMediatingMembrane ProteinsModelingMucous MembraneMusNeisseria gonorrhoeaeNutrientPathway interactionsPelvic Inflammatory DiseasePopulationProteinsS100A7SiteSourceStructureTestingTissuesTransferrinTransgenic MiceTreesUrethraVaccine DesignVaccinesVariantZincbactericidebasecomplement 4b-binding proteincross reactivitydesignepidemiological modelhumanized mouseimmunogenicityinnovationmalemathematical modelmouse modelpathogenprotective efficacyreproductive tracttooltransmission processvaccine developmentvaccine efficacyvaccine evaluation
项目摘要
This Core component will take advantage of our established vaccine evaluation pipeline, which includes our
innovative high throughput approaches facilitate our antigen engineering efforts by simultaneously allowing the
reactivity of antiserum to be measured against all known antigenic variants of a given protein, and our
humanized mouse-based infection models, which allow us to test the protective efficacy of vaccines during
gonococcal asymptomatic colonization and disease. The results generated by this Core are central to vaccine
design and formulation efforts being undertaken in Projects 1 and 2, and will be used to inform the vaccine
impact modeling being performed in Project 3.
该核心组件将利用我们已建立的疫苗评估管道,其中包括我们的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CYNTHIA N CORNELISSEN其他文献
CYNTHIA N CORNELISSEN的其他文献
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{{ truncateString('CYNTHIA N CORNELISSEN', 18)}}的其他基金
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
挨饿和杀死:针对淋球菌感染和疾病所必需的营养获取途径的工程抗原
- 批准号:
10595567 - 财政年份:2019
- 资助金额:
$ 2.75万 - 项目类别:
Rational design of transferrin binding protein-based vaccines to combat gonorrhea
合理设计基于转铁蛋白结合蛋白的淋病疫苗
- 批准号:
9888316 - 财政年份:2019
- 资助金额:
$ 2.75万 - 项目类别:
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
挨饿和杀死:针对淋球菌感染和疾病所必需的营养获取途径的工程抗原
- 批准号:
10355467 - 财政年份:2019
- 资助金额:
$ 2.75万 - 项目类别:
Using gonococcal TonB-dependent transporters as vaccine antigens
使用淋球菌 TonB 依赖性转运蛋白作为疫苗抗原
- 批准号:
10560825 - 财政年份:2019
- 资助金额:
$ 2.75万 - 项目类别:
Rational design of transferrin binding protein-based vaccines to combat gonorrhea
合理设计基于转铁蛋白结合蛋白的淋病疫苗
- 批准号:
10088372 - 财政年份:2019
- 资助金额:
$ 2.75万 - 项目类别:
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Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
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- 项目类别:青年科学基金项目
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