Administrative Core
行政核心
基本信息
- 批准号:10595568
- 负责人:
- 金额:$ 86.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-03-25 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AdjuvantAdministratorAnimalsAntigen TargetingAntigensCollaborationsCommunitiesComplexComputer ModelsCreativenessDiseaseDoctor of MedicineDoctor of PhilosophyEngineeringEnsureEnvironmentFemaleFormulationFosteringFundingGoalsGonorrheaHeterogeneityImmunologyInfrastructureInternationalLeadershipMembrane ProteinsModelingMonitorNational Institute of Allergy and Infectious DiseaseNeisseria gonorrhoeaeNutrientPathway interactionsProcessProductionProductivityProgress ReportsPropertyPublic OpinionResearchResearch PersonnelResistanceStarvationSupervisionSurveysTrainingTransferrin-Binding ProteinsUnited States National Institutes of HealthUniversitiesVaccine AntigenVaccinesVirginiacombatexperiencehuman subjectimprovedinfectious disease modelinnovationinternational centermalemeetingspredictive modelingpreventprogramsrational designrecruitreproductive tractresearch and developmentsuccesstimelinevaccine acceptancevaccine developmentvaccine discoveryvaccine distribution
项目摘要
The overall goal of the International Center for Gonococcal Vaccine Discovery, Formulation and
Implementation (ICGV) is to employ our established pipeline for vaccine antigen discovery to optimize the
antigenic properties of our selected outer membrane protein antigens as possible vaccine components.
Furthermore, our Center will utilize antigen diversity, global strain heterogeneity, and public acceptance
information to generate improved computer models that allow us to predict the success of any Ngo vaccine
deployed. The infrastructure and collaborations to enable success for projects and cores described in this
Center are already in place. The goal of the Administrative Core is to ensure that the ICGV is productive in its
goals towards rational engineering of our selected Ngo outer membrane protein antigens and deploying
predictive modeling approaches to integrate sequence and strain diversity with public opinion on STI vaccines.
The Administrative Core consists of the project and core leadership and a Core Administrator, and this group
will be supplemented by a panel of renowned vaccine experts as an external Scientific Advisory Board. The
specific aims of the Administrative Core are as follows: Aim 1. Provide coordination, supervision and
management that streamlines oversight of Center activities, while incentivizing synergistic and creative
approaches to achieving project milestones and objectives. Aim 2. Coordinate regulatory responsibilities of the
Center, including human subjects, animal subjects, training, compliance and NIH-related activities including
production of progress reports. Aim 3. Foster collaboration with other cores, including planning and supporting
multi-Center meetings. Aim 4. Function as an interface between projects, cores, the Scientific Advisory Board,
CRC executive committee and NIH/NIAID staff. Aim 5. Establish realistic timelines and monitor progress
towards these goals. When necessary, alternative strategies will be implemented to reach the project
milestones. Aim 6. Provide financial oversight of all projects and cores. Aim 7. Provide an environment
conducive to collaboration among the Core and Project investigators, ensuring investigators receive
appropriate recognition for their contributions to this complex team-based project. Aim 8. Implement the
Development and Research Program (DRP) to permit a competitive application process that will identify
promising young investigators and fund their Ngo-based vaccine development projects that will ultimately feed
into our pipeline and modeling. Innovative aspects of the Administrative Core include: the highly experienced
PI and the well-established collaborations of PI with the project/core leads; the established pipeline for vaccine
antigen discovery; the integration and deployment of an external Scientific Advisory Board; and the
supplemental funding for the Development and Research Program committed by the Office of Research and
Innovation at Virginia Commonwealth University.
国际淋球菌疫苗发现、配方和研究中心的总体目标
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CYNTHIA N CORNELISSEN其他文献
CYNTHIA N CORNELISSEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CYNTHIA N CORNELISSEN', 18)}}的其他基金
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
挨饿和杀死:针对淋球菌感染和疾病所必需的营养获取途径的工程抗原
- 批准号:
10595567 - 财政年份:2019
- 资助金额:
$ 86.64万 - 项目类别:
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
挨饿和杀死:针对淋球菌感染和疾病所必需的营养获取途径的工程抗原
- 批准号:
10355467 - 财政年份:2019
- 资助金额:
$ 86.64万 - 项目类别:
Rational design of transferrin binding protein-based vaccines to combat gonorrhea
合理设计基于转铁蛋白结合蛋白的淋病疫苗
- 批准号:
9888316 - 财政年份:2019
- 资助金额:
$ 86.64万 - 项目类别:
Using gonococcal TonB-dependent transporters as vaccine antigens
使用淋球菌 TonB 依赖性转运蛋白作为疫苗抗原
- 批准号:
10560825 - 财政年份:2019
- 资助金额:
$ 86.64万 - 项目类别:
Rational design of transferrin binding protein-based vaccines to combat gonorrhea
合理设计基于转铁蛋白结合蛋白的淋病疫苗
- 批准号:
10088372 - 财政年份:2019
- 资助金额:
$ 86.64万 - 项目类别:
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
挨饿和杀死:针对淋球菌感染和疾病所必需的营养获取途径的工程抗原
- 批准号:
10116966 - 财政年份:2019
- 资助金额:
$ 86.64万 - 项目类别:
相似海外基金
EAGER: Toward a Decentralized Cross-administrator Zone Management System: Policy and Technology
EAGER:走向去中心化的跨管理员区域管理系统:政策和技术
- 批准号:
2331936 - 财政年份:2023
- 资助金额:
$ 86.64万 - 项目类别:
Standard Grant
COLLABORATIVE RESEARCH: Social Influence in Eyewitness Identification Procedures: Do Blind Administrator Behaviors Magnify the Effects of Suspect Bias?
合作研究:目击者识别程序中的社会影响:盲目的管理员行为是否会放大嫌疑人偏见的影响?
- 批准号:
2043230 - 财政年份:2021
- 资助金额:
$ 86.64万 - 项目类别:
Continuing Grant
COLLABORATIVE RESEARCH: Social Influence in Eyewitness Identification Procedures: Do Blind Administrator Behaviors Magnify the Effects of Suspect Bias?
合作研究:目击者识别程序中的社会影响:盲目的管理员行为是否会放大嫌疑人偏见的影响?
- 批准号:
2043334 - 财政年份:2021
- 资助金额:
$ 86.64万 - 项目类别:
Continuing Grant
Making of the base for patient safety management skill of visiting nurse administrator by the web conference system
利用网络会议系统构建出诊护士管理者患者安全管理技能基础
- 批准号:
19K10768 - 财政年份:2019
- 资助金额:
$ 86.64万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of the nursing administrator training program to improve leadership behavior focused on emotional intelligence
制定护理管理人员培训计划,以改善以情商为重点的领导行为
- 批准号:
18K17464 - 财政年份:2018
- 资助金额:
$ 86.64万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Automated Network Management that Dynamically Reflects Administrator Intent
动态反映管理员意图的自动化网络管理
- 批准号:
18K18038 - 财政年份:2018
- 资助金额:
$ 86.64万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Administrator support perceived as useful for professional growth by novice psychiatric home-visit nursing staff
新手精神科家访护理人员认为管理员支持对专业成长有用
- 批准号:
17H07005 - 财政年份:2017
- 资助金额:
$ 86.64万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
The Facts and Problems on Management of Public Museums: Validation of Designated Administrator System
公共博物馆管理的事实与问题:指定管理员制度的验证
- 批准号:
17K01212 - 财政年份:2017
- 资助金额:
$ 86.64万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A Study on Transformation of the School Administrator Preparation and Evaluation System in the United States
美国学校管理人员培养与评价体系转型研究
- 批准号:
26780449 - 财政年份:2014
- 资助金额:
$ 86.64万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
The Family Court's Supervision of Property Administrator
家庭法院对财产管理人的监督
- 批准号:
26380108 - 财政年份:2014
- 资助金额:
$ 86.64万 - 项目类别:
Grant-in-Aid for Scientific Research (C)