Administrative Core

行政核心

基本信息

  • 批准号:
    10595568
  • 负责人:
  • 金额:
    $ 86.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-03-25 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

The overall goal of the International Center for Gonococcal Vaccine Discovery, Formulation and Implementation (ICGV) is to employ our established pipeline for vaccine antigen discovery to optimize the antigenic properties of our selected outer membrane protein antigens as possible vaccine components. Furthermore, our Center will utilize antigen diversity, global strain heterogeneity, and public acceptance information to generate improved computer models that allow us to predict the success of any Ngo vaccine deployed. The infrastructure and collaborations to enable success for projects and cores described in this Center are already in place. The goal of the Administrative Core is to ensure that the ICGV is productive in its goals towards rational engineering of our selected Ngo outer membrane protein antigens and deploying predictive modeling approaches to integrate sequence and strain diversity with public opinion on STI vaccines. The Administrative Core consists of the project and core leadership and a Core Administrator, and this group will be supplemented by a panel of renowned vaccine experts as an external Scientific Advisory Board. The specific aims of the Administrative Core are as follows: Aim 1. Provide coordination, supervision and management that streamlines oversight of Center activities, while incentivizing synergistic and creative approaches to achieving project milestones and objectives. Aim 2. Coordinate regulatory responsibilities of the Center, including human subjects, animal subjects, training, compliance and NIH-related activities including production of progress reports. Aim 3. Foster collaboration with other cores, including planning and supporting multi-Center meetings. Aim 4. Function as an interface between projects, cores, the Scientific Advisory Board, CRC executive committee and NIH/NIAID staff. Aim 5. Establish realistic timelines and monitor progress towards these goals. When necessary, alternative strategies will be implemented to reach the project milestones. Aim 6. Provide financial oversight of all projects and cores. Aim 7. Provide an environment conducive to collaboration among the Core and Project investigators, ensuring investigators receive appropriate recognition for their contributions to this complex team-based project. Aim 8. Implement the Development and Research Program (DRP) to permit a competitive application process that will identify promising young investigators and fund their Ngo-based vaccine development projects that will ultimately feed into our pipeline and modeling. Innovative aspects of the Administrative Core include: the highly experienced PI and the well-established collaborations of PI with the project/core leads; the established pipeline for vaccine antigen discovery; the integration and deployment of an external Scientific Advisory Board; and the supplemental funding for the Development and Research Program committed by the Office of Research and Innovation at Virginia Commonwealth University.
国际淋球菌疫苗发现、配制和研究中心的总体目标是 实施(ICGV)是利用我们建立的疫苗抗原发现渠道来优化 我们选择的外膜蛋白抗原作为可能的疫苗成分的抗原性。 此外,我们的中心将利用抗原多样性、全球菌株异质性和公众接受度 用于生成改进的计算机模型的信息,这些模型允许我们预测任何NGO疫苗的成功 已部署。基础架构和协作,使本指南中所述的项目和核心取得成功 中心已经就位。行政核心的目标是确保ICGV在其 我们选择的NGO外膜蛋白抗原的合理工程和部署的目标 将序列和菌株多样性与公众对STI疫苗的意见相结合的预测建模方法。 行政核心由项目和核心领导和一名核心管理员组成,该小组 将有一个由著名疫苗专家组成的小组作为外部科学咨询委员会的补充。这个 行政核心的具体目标如下:目标1.提供协调、监督和 简化对中心活动的监督,同时激励协同和创造性的管理 实现项目里程碑和目标的方法。目标2.协调监管机构的职责 中心,包括人类受试者、动物受试者、培训、遵从性和与NIH相关的活动,包括 制作进度报告。目标3.促进与其他核心部门的合作,包括规划和支助 多中心会议。目标4.作为项目、核心、科学咨询委员会、 儿童权利公约执行委员会和NIH/NIAID的工作人员。目标5.制定切合实际的时间表并监测进展 朝着这些目标前进。必要时,将实施替代战略以达到项目的目的。 里程碑。目标6.为所有项目和核心提供财务监督。目标7.提供环境 有利于核心调查员和项目调查员之间的合作,确保调查员 对他们对这个复杂的基于团队的项目的贡献给予适当的认可。目标8.落实 开发和研究计划(DRP),以允许竞争性申请过程,以确定 并为他们基于NGO的疫苗开发项目提供资金,这些项目最终将 进入我们的流水线和模特。行政核心的创新方面包括:经验丰富的 PI和PI与项目/核心领导的良好合作;已建立的疫苗流水线 抗原发现;整合和部署外部科学咨询委员会; 为研究和研究办公室承诺的开发和研究方案提供补充资金 弗吉尼亚联邦大学的创新。

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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CYNTHIA N CORNELISSEN其他文献

CYNTHIA N CORNELISSEN的其他文献

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{{ truncateString('CYNTHIA N CORNELISSEN', 18)}}的其他基金

Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
挨饿和杀死:针对淋球菌感染和疾病所必需的营养获取途径的工程抗原
  • 批准号:
    10595567
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:
Rational design of transferrin binding protein-based vaccines to combat gonorrhea
合理设计基于转铁蛋白结合蛋白的淋病疫苗
  • 批准号:
    9888316
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
挨饿和杀死:针对淋球菌感染和疾病所必需的营养获取途径的工程抗原
  • 批准号:
    10355467
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:
Project-003
项目-003
  • 批准号:
    10330128
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:
Project-002
项目-002
  • 批准号:
    10330127
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:
Using gonococcal TonB-dependent transporters as vaccine antigens
使用淋球菌 TonB 依赖性转运蛋白作为疫苗抗原
  • 批准号:
    10560825
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:
Rational design of transferrin binding protein-based vaccines to combat gonorrhea
合理设计基于转铁蛋白结合蛋白的淋病疫苗
  • 批准号:
    10088372
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:
ConProject-005
ConProject-005
  • 批准号:
    10311807
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:
Core-002
核心002
  • 批准号:
    10330126
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:
Starve and Kill: Engineered Antigens Targeting Nutrient Acquisition Pathways Essential for Gonococcal Infection and Disease
挨饿和杀死:针对淋球菌感染和疾病所必需的营养获取途径的工程抗原
  • 批准号:
    10116966
  • 财政年份:
    2019
  • 资助金额:
    $ 86.64万
  • 项目类别:

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  • 批准号:
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