Predoctoral Training Program in Molecular Pharmacology

项目总结 我们在药理科学(PS)的项目领域提交这一申请。的主要目标是 梅奥分子药理学与实验治疗(MPET)博士培养计划 临床生物医学研究生院(MCGSBS)是独立研究人员的发展 能够指导学术界、工业界或其他领域的杰出研究项目。教职员工是 由28名资金充足的独立调查人员组成，他们来自世界各地的部门和部门 该机构和世卫组织专注于一系列研究领域，包括基础分子研究 通过药物发现和疾病新疗法的开发，对疾病的遗传方面进行研究。这个 学院提供系统药理学、人工智能、 计算化学，药物作用和耐药的分子机制，代谢组学，新 治疗策略、成瘾遗传学、临床前和临床药理学以及药物基因组学 与药物反应相关的基因。46名博士后(博士生和博士/博士生)， 来自不同背景的学生，目前正在参加MPET博士培训计划。严谨的说教 课程包括一系列核心课程，以确保扎实的基础知识 生物化学、分子生物学、遗传学、统计学、细胞生物学和药理学以及一系列 以辅导为基础的课程，提供药理科学方面的高级培训。在他们的头两年 在学习过程中，学生完成实验室轮换，并选择一个实验室进行论文研究。他们 在第三年年底前完成全面的笔试和口试。严谨和 在整个培训计划中都编织了重复性，预计学生将达到最高 科学诚信的标准。在制定了一份书面论文提案后，列出了问题和 在论文研究中将采取的方法，论文咨询委员会审查了拟议的 在第一次委员会会议上进行研究。学生介绍他们的研究项目的最新工作情况 每年取悦教职员工和学生。受训者被要求培养独立性，并在 至少有一篇第一作者的文章。在过去的15年里，MPET学员平均发表了2.2篇第一作者的文章 论文总数5.6篇)。从三年级开始，学生们与他们的论文咨询委员会在 每年至少两次。完成博士学位的平均时间为5.9年。MPET博士毕业生 培训计划有着出色的记录，许多学生建立了新的研究方向， 对导师的研究项目有长期的影响。他们继续获得博士后奖学金，与 许多人现在担任学术界和工业界的首席研究员。我们需要6个T32资助的职位。

PROJECT SUMMARY We are submitting this application in the program area of Pharmacological Sciences (PS). The primary goal of the PhD Training Program in Molecular Pharmacology and Experimental Therapeutics (MPET) in the Mayo Clinic Graduate School of Biomedical Sciences (MCGSBS) is the development of independent investigators capable of directing outstanding research programs in academia, industry, or other settings. The faculty is comprised of 28 well-funded, independent investigators who are drawn from departments and divisions across the institution and who focus on a continuum of research areas encompassing studies from basic molecular and genetic aspects of disease through drug discovery and development of novel therapies for diseases. The faculty provides training opportunities in areas that include systems pharmacology, artificial intelligence, computational chemistry, molecular mechanisms of drug action and resistance, metabolomics, novel therapeutic strategies, the genetics of addiction, preclinical and clinical pharmacology, and pharmacogenomics of genes associated with drug responses. Forty-six predoctoral students (PhD and MD/PhD in PhD training), from diverse backgrounds, are currently enrolled in the MPET PhD training program. A rigorous didactic curriculum includes a series of Core Curriculum courses that ensures strong fundamental knowledge in biochemistry, molecular biology, genetics, statistics, cell biology and pharmacology as well as a series of tutorial-based courses that provide advanced training in pharmacological sciences. During their first two years of study, students complete laboratory rotations and select a laboratory for their thesis research. They complete comprehensive written and oral qualifying examinations by the end of Year 3. Training in rigor and reproducibility is woven throughout the training program and students are expected to meet the highest standards of scientific integrity. After developing a written thesis proposal delineating the questions and approaches to be pursued in the thesis research, the Thesis Advisory Committee reviews the proposed research at the first committee meeting. Students present work-in-progress updates on their research projects to MPET faculty and students each year. Trainees are required to develop independence and to publish at least one first-author article. In the last 15 years, MPET trainees have averaged over 2.2 first-author articles and 5.6 total articles). Starting in Year 3 and beyond, students meet with their Thesis Advisory Committees at least twice per year. The average time to completion of the PhD is 5.9 years. Graduates of the MPET PhD training program have outstanding track records, with many students establishing new research directions that have long-lasting impacts on the mentor’s research programs. They go on to postdoctoral fellowships, with many now serving as principal investigators in academia and industry. We request 6 T32-funded positions.