Predoctoral Training Program in Molecular Pharmacology

项目摘要 我们在药理学科学（PS）的程序领域提交此申请。的首要目标 马约的分子药理学和实验治疗学（MPET）博士培训计划 临床生物医学科学研究生院（MCGSBS）是独立研究人员的发展 能够指导学术界，工业界或其他环境中的杰出研究计划。该学院是 由28名资金充足的独立调查员组成，他们来自各部门和各司， 这些机构和世卫组织集中于一系列研究领域，包括从基础分子 通过药物发现和疾病新疗法的开发来研究疾病的遗传方面。的 教师提供培训机会，包括系统药理学，人工智能， 计算化学，药物作用和耐药性的分子机制，代谢组学，新 治疗策略、成瘾遗传学、临床前和临床药理学以及药物基因组学 与药物反应相关的基因。46名博士预科生（博士和博士/博士在博士培训）， 来自不同背景，目前正在参加MPET博士培训计划。严格的说教 课程包括一系列核心课程，确保在以下方面有很强的基础知识： 生物化学，分子生物学，遗传学，统计学，细胞生物学和药理学以及一系列 提供药理学高级培训的辅导课程。在头两年里 学生完成实验室轮换，并选择一个实验室进行论文研究。他们 在3年级结束前完成综合笔试和口试。严格培训， 再现性是编织在整个培训计划，学生预计将达到最高 科学诚信的标准。在编写了一份书面论文提案后， 在论文研究中要追求的方法，论文咨询委员会审查了拟议的 在第一次委员会会议上。学生们介绍他们的研究项目的最新进展 教师和学生每年。学员必须培养独立性，并在 至少一篇第一作者文章。在过去的15年里，MPET学员平均发表超过2.2篇第一作者文章 共5.6篇文章）。从3年级及以后开始，学生将在以下地点与他们的论文咨询委员会会面： 每年至少两次。完成博士学位的平均时间为5.9年。MPET博士毕业生 培训计划有出色的跟踪记录，许多学生建立新的研究方向， 对导师的研究计划产生长期影响。他们继续博士后奖学金， 许多人现在担任学术界和工业界的主要研究人员。我们申请6个T32资助的职位。

PROJECT SUMMARY We are submitting this application in the program area of Pharmacological Sciences (PS). The primary goal of the PhD Training Program in Molecular Pharmacology and Experimental Therapeutics (MPET) in the Mayo Clinic Graduate School of Biomedical Sciences (MCGSBS) is the development of independent investigators capable of directing outstanding research programs in academia, industry, or other settings. The faculty is comprised of 28 well-funded, independent investigators who are drawn from departments and divisions across the institution and who focus on a continuum of research areas encompassing studies from basic molecular and genetic aspects of disease through drug discovery and development of novel therapies for diseases. The faculty provides training opportunities in areas that include systems pharmacology, artificial intelligence, computational chemistry, molecular mechanisms of drug action and resistance, metabolomics, novel therapeutic strategies, the genetics of addiction, preclinical and clinical pharmacology, and pharmacogenomics of genes associated with drug responses. Forty-six predoctoral students (PhD and MD/PhD in PhD training), from diverse backgrounds, are currently enrolled in the MPET PhD training program. A rigorous didactic curriculum includes a series of Core Curriculum courses that ensures strong fundamental knowledge in biochemistry, molecular biology, genetics, statistics, cell biology and pharmacology as well as a series of tutorial-based courses that provide advanced training in pharmacological sciences. During their first two years of study, students complete laboratory rotations and select a laboratory for their thesis research. They complete comprehensive written and oral qualifying examinations by the end of Year 3. Training in rigor and reproducibility is woven throughout the training program and students are expected to meet the highest standards of scientific integrity. After developing a written thesis proposal delineating the questions and approaches to be pursued in the thesis research, the Thesis Advisory Committee reviews the proposed research at the first committee meeting. Students present work-in-progress updates on their research projects to MPET faculty and students each year. Trainees are required to develop independence and to publish at least one first-author article. In the last 15 years, MPET trainees have averaged over 2.2 first-author articles and 5.6 total articles). Starting in Year 3 and beyond, students meet with their Thesis Advisory Committees at least twice per year. The average time to completion of the PhD is 5.9 years. Graduates of the MPET PhD training program have outstanding track records, with many students establishing new research directions that have long-lasting impacts on the mentor’s research programs. They go on to postdoctoral fellowships, with many now serving as principal investigators in academia and industry. We request 6 T32-funded positions.