Predoctoral Training Program in Molecular Pharmacology

分子药理学博士前培训项目

• 批准号: 10642662
• 负责人: DOO-SUP CHOI
• 金额: $ 31.83万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642662
• 关键词: Molecular; Pharmacology; Training Programs; pre-doctoral

PROJECT SUMMARY We are submitting this application in the program area of Pharmacological Sciences (PS). The primary goal of the PhD Training Program in Molecular Pharmacology and Experimental Therapeutics (MPET) in the Mayo Clinic Graduate School of Biomedical Sciences (MCGSBS) is the development of independent investigators capable of directing outstanding research programs in academia, industry, or other settings. The faculty is comprised of 28 well-funded, independent investigators who are drawn from departments and divisions across the institution and who focus on a continuum of research areas encompassing studies from basic molecular and genetic aspects of disease through drug discovery and development of novel therapies for diseases. The faculty provides training opportunities in areas that include systems pharmacology, artificial intelligence, computational chemistry, molecular mechanisms of drug action and resistance, metabolomics, novel therapeutic strategies, the genetics of addiction, preclinical and clinical pharmacology, and pharmacogenomics of genes associated with drug responses. Forty-six predoctoral students (PhD and MD/PhD in PhD training), from diverse backgrounds, are currently enrolled in the MPET PhD training program. A rigorous didactic curriculum includes a series of Core Curriculum courses that ensures strong fundamental knowledge in biochemistry, molecular biology, genetics, statistics, cell biology and pharmacology as well as a series of tutorial-based courses that provide advanced training in pharmacological sciences. During their first two years of study, students complete laboratory rotations and select a laboratory for their thesis research. They complete comprehensive written and oral qualifying examinations by the end of Year 3. Training in rigor and reproducibility is woven throughout the training program and students are expected to meet the highest standards of scientific integrity. After developing a written thesis proposal delineating the questions and approaches to be pursued in the thesis research, the Thesis Advisory Committee reviews the proposed research at the first committee meeting. Students present work-in-progress updates on their research projects to MPET faculty and students each year. Trainees are required to develop independence and to publish at least one first-author article. In the last 15 years, MPET trainees have averaged over 2.2 first-author articles and 5.6 total articles). Starting in Year 3 and beyond, students meet with their Thesis Advisory Committees at least twice per year. The average time to completion of the PhD is 5.9 years. Graduates of the MPET PhD training program have outstanding track records, with many students establishing new research directions that have long-lasting impacts on the mentor’s research programs. They go on to postdoctoral fellowships, with many now serving as principal investigators in academia and industry. We request 6 T32-funded positions.

项目概要 我们正在药理学科学 (PS) 项目领域提交此申请。主要目标是 梅奥大学分子药理学和实验治疗学 (MPET) 博士培训项目 临床生物医学科学研究生院（MCGSBS）是独立研究者的发展 能够在学术界、工业界或其他环境中指导杰出的研究项目。院系是 由来自各部门和部门的 28 名资金充足的独立调查员组成 该机构和谁专注于一系列研究领域，包括基础分子研究 通过药物发现和疾病新疗法的开发来了解疾病的遗传方面。这 教师提供系统药理学、人工智能、 计算化学、药物作用和耐药性的分子机制、代谢组学、新颖 治疗策略、成瘾遗传学、临床前和临床药理学以及药物基因组学 与药物反应相关的基因。 46名博士前学生（博士生和博士生/博士生）， 来自不同背景的学生目前正在参加 MPET 博士培训项目。严谨的教学 课程包括一系列核心课程，确保扎实的基础知识 生物化学、分子生物学、遗传学、统计学、细胞生物学和药理学以及一系列 基于教程的课程，提供药理学科学方面的高级培训。在他们的头两年里 在学习过程中，学生完成实验室轮换并选择一个实验室进行论文研究。他们 在第三年年底之前完成全面的笔试和口试资格考试。 可重复性贯穿整个培训计划，学生应达到最高标准 科学诚信的标准。在制定了描述问题的书面论文提案并 论文研究中要采用的方法，论文咨询委员会审查拟议的方法 第一次委员会会议上的研究。学生展示他们研究项目的最新进展 每年向 MPET 教职员工和学生提供。学员必须培养独立性并在以下网站发表文章： 至少一篇第一作者文章。在过去 15 年中，MPET 学员平均发表第一作者文章超过 2.2 篇 总共 5.6 篇文章）。从三年级及以后开始，学生将与他们的论文咨询委员会会面： 每年至少两次。完成博士学位的平均时间为 5.9 年。 MPET 博士毕业生 培训项目有着出色的记录，许多学生建立了新的研究方向 对导师的研究项目产生长期影响。他们继续获得博士后奖学金， 许多人现在担任学术界和工业界的主要研究人员。我们请求 6 个由 T32 资助的职位。