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Project Summary In humans and rodents, abnormal sleep patterns are risk factors for excessive alcohol consumption. Alcohol-dependent subjects, both during a drinking period and during withdrawal, suffer from a multitude of sleep disruptions. During alcohol withdrawal, recovering alcohol-dependent patients commonly experience severe and protracted sleep disruptions manifested by profound insomnia along with excessive daytime sleepiness. Sleep disturbances during alcohol recovery can increase the risk of relapse to alcohol use. However, the neural mechanisms responsible for mediating the effects of ethanol on sleep remain largely unknown. Based on recent findings, we hypothesize that repeated ethanol exposure disrupts sleep patterns through the striato-basal forebrain (NAc-BF) circuit in sex-dependent manner. To test our hypothesis, we will 1) examine the effects of repeated ethanol-withdrawal on sleep disturbance patterns, 2) determine the activities of the NAc-BF circuit in ethanol withdrawal-induced sleep disturbance, and 3) Investigate the effects of the NAc-BF circuit manipulations in ethanol withdrawal-induced sleep disturbance. Our study will reveal neural basis of how NAc-BF circuits contribute to chronic ethanol- induced sleep disturbance. We expect to elucidate the sex-dependent sleep disturbance during the course of ethanol exposures. The outcomes of our study will be a critical research foundation for future R01 research to discover and comprehensively characterize neural circuits and molecular mechanisms underlying ethanol-induced sleep disturbance, which may translate into clinical studies and identify novel therapeutic targets.
期刊论文(7)
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会议论文
DOI: 10.1016/j.jpsychires.2024.02.002
发表时间: 2024-02
期刊: Journal of psychiatric research
影响因子: 4.8
作者: [Humza Haroon;Ada M.-C. Ho;Vinod K. Gupta;Surendra Dasari;Carl M. Sellgren;S. Cervenka;G. Engberg;Feride Eren;Sophie Erhardt;J. Sung;Doo-Sup Choi]
通讯作者: Humza Haroon;Ada M.-C. Ho;Vinod K. Gupta;Surendra Dasari;Carl M. Sellgren;S. Cervenka;G. Engberg;Feride Eren;Sophie Erhardt;J. Sung;Doo-Sup Choi
DOI: 10.3390/cells11020286
发表时间: 2022-01-15
期刊: Cells
影响因子: 6
作者: [Essa H, Peyton L, Hasan W, León BE, Choi DS]
通讯作者: Choi DS
External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice.
帕利德斯外部对背纹状体的输入可调节雄性小鼠的习惯性寻求行为。
DOI: 10.1038/s41467-023-39545-8
发表时间: 2023-07-12
期刊: Nature communications
影响因子: 16.6
作者: [Baker M, Kang S, Hong SI, Song M, Yang MA, Peyton L, Essa H, Lee SW, Choi DS]
通讯作者: Choi DS
Predoctoral Training Program in Molecular Pharmacology
  • 批准号:
    10331450
  • 项目类别:
  • 资助金额:
    $31.22万
  • 财政年份:
    2022
  • 负责人:
    DOO-SUP CHOI
  • 依托单位:
Predoctoral Training Program in Molecular Pharmacology
  • 批准号:
    10642662
  • 项目类别:
  • 资助金额:
    $31.83万
  • 财政年份:
    2022
  • 负责人:
    DOO-SUP CHOI
  • 依托单位:
Neural Basis of Ethanol Withdrawal-Induced Sleep Disturbance
  • 批准号:
    10229117
  • 项目类别:
  • 资助金额:
    $22.86万
  • 财政年份:
    2021
  • 负责人:
    DOO-SUP CHOI
  • 依托单位:
Astrocyte-Neuron Interaction in the Dorsal Striatum and Ethanol-Seeking Behaviors
  • 批准号:
    10414969
  • 项目类别:
  • 资助金额:
    $35.78万
  • 财政年份:
    2021
  • 负责人:
    DOO-SUP CHOI
  • 依托单位:
国内基金
海外基金
湍流和化学交互作用对H2-Air-H2O微混燃烧中NO生成的影响研究
  • 批准号:
    51976048
  • 项目类别:
    面上项目
  • 资助金额:
    61.0万元
  • 批准年份:
    2019
  • 负责人:
    邱朋华
  • 依托单位: