Regulation of spore peptidoglycan modification
Regulation of spore peptidoglycan modification
批准号:
10331314
负责人:
Aimee Shen
金额:
$32.37万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-02-01 至 2024-11-30
关键词:
AcuteAffectAnaerobic BacteriaAttenuatedBacillus subtilisBacteriaBacterial SporesBindingBiochemicalBiologicalBiological AssayCell WallCellsCenters for Disease Control and Prevention (U.S.)Chimeric ProteinsClostridium difficileClostridium perfringensComplementComplexCrystallizationDataDeacetylaseDefectDependenceDevelopmentDigestionDiseaseEnzymesEscherichia coliExhibitsFamilyFamily memberFluorescence Resonance Energy TransferGenomeGerminationGoalsGrowthHealthcare SystemsIn VitroIndividualInfectionLactamsLicensingLipoprotein (a)LipoproteinsLocationLytA enzymeMeasuresMediatingMembraneMetabolicModelingModificationMutationMutation AnalysisN-acetylmuramic acidPatternPeptidoglycanPhysiologyProcessProteinsRecording of previous eventsRecurrenceRegulationReporterReproduction sporesRoleStructureSystemTechniquesTestingThickVirulenceWorkZincamidasebasecomparativedisease transmissioninsightmembermutantpathogenpathogenic bacteriapreventrecruit
中文摘要
摘要
细菌病原体艰难梭状芽孢杆菌被认为是对美国医疗保健的紧急威胁
疾病控制中心的系统。艰难梭菌为了引发感染,其感染性孢子形态
必须在易感人群的肠道中萌发。由于孢子萌发依赖于孢子细胞壁
在经历了特定的修饰之后,确定艰难梭菌中这一过程是如何发生的,可能会让
制定预防艰难梭菌疾病传播和复发的策略。
英文摘要
SUMMARY
The bacterial pathogen, Clostridioides difficile, has been designated an urgent threat to the US healthcare
system by the Centers for Disease Control. In order for C. difficile to initiate infection, its infectious spore form
must germinate in the gut of susceptible individuals. Since spore germination depends on the spore cell wall
undergoing specific modifications, determining how this process occurs in C. difficile could inform the
development of strategies for preventing C. difficile disease transmission and recurrence.
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Regulation of spore peptidoglycan modification
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批准号:10530682
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项目类别:
-
资助金额:$32.37万
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财政年份:2021
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负责人:Aimee Shen
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依托单位:
Linking Gene Expression Profiles to Cell Fate in Clostridioides difficile Using Time-Lapse Microscopy
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批准号:10330034
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项目类别:
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资助金额:$24.36万
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财政年份:2021
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负责人:Aimee Shen
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依托单位:
Regulation of spore peptidoglycan modification
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批准号:10096439
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项目类别:
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资助金额:$35.62万
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财政年份:2021
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负责人:Aimee Shen
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依托单位:
Linking Gene Expression Profiles to Cell Fate in Clostridioides difficile Using Time-Lapse Microscopy
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批准号:10223787
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项目类别:
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资助金额:$21.86万
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财政年份:2021
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负责人:Aimee Shen
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依托单位:
Spore Assembly in Clostridioides difficile
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批准号:10365431
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项目类别:
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资助金额:$43.74万
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财政年份:2016
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负责人:Aimee Shen
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依托单位:
Identifying Factors That Control Germinant Sensitivity During Clostridium Difficile Spore Germination
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批准号:9293255
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项目类别:
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资助金额:$20.12万
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财政年份:2016
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负责人:Aimee Shen
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依托单位:
Spore Assembly in Clostridioides difficile
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批准号:10676850
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项目类别:
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资助金额:$43.74万
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财政年份:2016
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负责人:Aimee Shen
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依托单位:
Spore Assembly in Clostridium Difficile
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批准号:9186980
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项目类别:
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资助金额:$40.87万
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财政年份:2016
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负责人:Aimee Shen
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依托单位:
Spore Assembly in Clostridium Difficile
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批准号:9316207
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项目类别:
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资助金额:$15.78万
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财政年份:2016
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负责人:Aimee Shen
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依托单位:
Regulation of Spore Germination in Clostridioides difficile
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批准号:10743652
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项目类别:
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资助金额:$33.38万
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财政年份:2014
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负责人:Aimee Shen
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依托单位:
Proteolytic Regulation of Spore Germination in Clostridium difficile
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批准号:8889696
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项目类别:
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资助金额:$28.98万
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财政年份:2014
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负责人:Aimee Shen
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依托单位:
Proteolytic Regulation of Spore Germination in Clostridium difficile
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批准号:9341343
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项目类别:
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资助金额:$27.36万
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财政年份:2014
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负责人:Aimee Shen
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依托单位:
Proteolytic Regulation of Spore Germination in Clostridium difficile
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批准号:8760059
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项目类别:
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资助金额:$28.98万
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财政年份:2014
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负责人:Aimee Shen
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依托单位:
Chemically Interrogating Clostridium difficile Glucosylating Toxin Activation
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批准号:7871584
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项目类别:
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资助金额:$8.2万
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财政年份:2010
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负责人:Aimee Shen
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依托单位:
Chemically Interrogating Clostridium difficile Glucosylating Toxin Activation
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批准号:8241337
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项目类别:
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资助金额:$24.9万
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财政年份:2010
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负责人:Aimee Shen
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依托单位:
Chemically Interrogating Clostridium difficile Glucosylating Toxin Activation
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批准号:8457113
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项目类别:
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资助金额:$23.11万
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财政年份:2010
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负责人:Aimee Shen
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依托单位:
Chemically Interrogating Clostridium difficile Glucosylating Toxin Activation
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批准号:8250328
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项目类别:
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资助金额:$24.43万
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财政年份:2010
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负责人:Aimee Shen
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依托单位:
海外基金