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Regulation of spore peptidoglycan modification

Regulation of spore peptidoglycan modification
孢子肽聚糖修饰的调控
批准号：
10096439
负责人：
Aimee Shen
金额：
$35.62万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
已结题
起止时间：
2021-02-01 至 2024-11-30
来源：
https://reporter.nih.gov/project-details/10096439
关键词：
AcuteAffectAnaerobic BacteriaAttenuatedBacillus subtilisBacteriaBacterial SporesBindingBiochemicalBiologicalBiological AssayCell WallCellsCenters for Disease Control and Prevention (U.S.)Chimeric ProteinsClostridium difficileClostridium perfringensComplementComplexCrystallizationDataDeacetylaseDefectDependenceDevelopmentDigestionDiseaseEnzymesEscherichia coliExhibitsFamilyFamily memberFluorescence Resonance Energy TransferGenomeGerminationGoalsGrowthHealthcare SystemsIn VitroIndividualInfectionLactamsLicensingLipoprotein (a)LipoproteinsLocationLytA enzymeMeasuresMediatingMembraneMetabolicModelingModificationMutationMutation AnalysisN-acetylmuramic acidPatternPeptidoglycanPhysiologyProcessProteinsRecording of previous eventsRecurrenceRegulationReporterReproduction sporesRoleStructureSystemTechniquesTestingThickVirulenceWorkZincamidasebasecomparativedisease transmissioninsightmembermutantpathogenpathogenic bacteriapreventrecruit

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SUMMARY The bacterial pathogen, Clostridioides difficile, has been designated an urgent threat to the US healthcare system by the Centers for Disease Control. In order for C. difficile to initiate infection, its infectious spore form must germinate in the gut of susceptible individuals. Since spore germination depends on the spore cell wall undergoing specific modifications, determining how this process occurs in C. difficile could inform the development of strategies for preventing C. difficile disease transmission and recurrence.
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Regulation of spore peptidoglycan modification
  • 批准号：
    10331314
  • 项目类别：
  • 资助金额：
    $32.37万
  • 财政年份：
    2021
  • 负责人：
    Aimee Shen
  • 依托单位：
    TUFTS UNIVERSITY BOSTON
Regulation of spore peptidoglycan modification
  • 批准号：
    10530682
  • 项目类别：
  • 资助金额：
    $32.37万
  • 财政年份：
    2021
  • 负责人：
    Aimee Shen
  • 依托单位：
    TUFTS UNIVERSITY BOSTON
Linking Gene Expression Profiles to Cell Fate in Clostridioides difficile Using Time-Lapse Microscopy
  • 批准号：
    10330034
  • 项目类别：
  • 资助金额：
    $24.36万
  • 财政年份：
    2021
  • 负责人：
    Aimee Shen
  • 依托单位：
    TUFTS UNIVERSITY BOSTON
Linking Gene Expression Profiles to Cell Fate in Clostridioides difficile Using Time-Lapse Microscopy
  • 批准号：
    10223787
  • 项目类别：
  • 资助金额：
    $21.86万
  • 财政年份：
    2021
  • 负责人：
    Aimee Shen
  • 依托单位：
    TUFTS UNIVERSITY BOSTON
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