Illuminating development of infant and toddler brainfunction with DOT

用 DOT 阐明婴幼儿脑功能的发育

• 批准号: 10337335
• 负责人: Adam Thomas Eggebrecht
• 金额: $ 57.96万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10337335
• 关键词: 3-Dimensional; Address; Adult; Affect; Age; Age-Months; Algorithms; Anatomy; Auditory; Award; Basic Science; Behavior; Behavior Therapy; Behavior assessment; Behavioral; Behavioral Assay; Behavioral Symptoms; Biological; Brain; Brain Mapping; Brain imaging; Child; Childhood; Claustrophobias; Clinical; Clinical Research; Clip; Cognitive deficits; Data; Data Set; Development; Diagnosis; Diagnostic; Dimensions; Early Diagnosis; Early Intervention; Educational Intervention; Environment; Eye; Functional Magnetic Resonance Imaging; Future; General Population; Genetic; Goals; Head; Heritability; Image; Impairment; Infant; Infant Development; Intervention; Language; Language Delays; Learning; Life; Light; Linear Regressions; Linguistics; Longitudinal prospective study; Loudness; Magnetic Resonance Imaging; Maps; Measures; Mental disorders; Methodology; Methods; Mission; Modality; Modeling; Monitor; Morphologic artifacts; Motion; Motor; National Institute of Mental Health; Neurocognitive; Neurodevelopmental Disorder; Noise; Optics; Parents; Participant; Pathway interactions; Phenotype; Predisposition; Prevention; Prognosis; Psychopathology; Quality of life; Questionnaires; Recovery; Reporting; Research; Research Personnel; Risk; Risk Marker; Sampling; Scanning; Science; Scientist; Series; Software Tools; Supination; Surface; Techniques; Technology; Temperament; Therapeutic Intervention; Toddler; United States; Visit; Visual; autism spectrum disorder; autistic; awake; base; behavior measurement; behavioral impairment; biobehavior; brain behavior; case control; cohort; cost; density; diffuse optical tomography; early childhood; flexibility; functional near infrared spectroscopy; gaze; improved; improved outcome; individual variation; innovation; interest; male; movie; neuroimaging; novel; optical imaging; patient subsets; predictive test; programs; prospective; relating to nervous system; repetitive behavior; response; social; social communication; social skills; treatment strategy; visual tracking

Project Summary/Abstract The long-term goal of these studies is to advance high-density diffuse optical tomography (HD-DOT) methods for evaluating brain-behavior relationships in infants and toddlers at risk for developing autism spectrum disorder (ASD) while they are awake and engaged within a naturalistic setting. This application is being submitted in response to FOA: RFA-MH-18-200, NIMH Biobehavioral Research Awards for Innovative New Scientists (BRAINS R01), because the PI is an early stage investigator who is building a program of research that is highly innovative, transformative, and has the potential to elucidate underlying mechanisms, inform clinical interventions, and improve outcome of ASD. As such, this research is harmonious with the mission of NIMH: to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. ASD, defined by deficits in social communication and restricted interests/repetitive behaviors, is a serious psychiatric disorder of childhood, is treatable but currently incurable, and affects an estimated 1 in 59 children in the United States at an estimated annual cost of $268B. Early behavioral and educational interventions, starting at 18-24 months of age, improve outcomes in a subset of patients. Neuroimaging methods, including both task-based functional magnetic resonance imaging (fMRI) and task-free functional connectivity MRI, have demonstrated sensitivity to neural signatures of ASD that may inform diagnosis and track responses to interventions. However, the MRI environment can prove intolerable for many children due to noise, claustrophobia, and the need to lie supine and still. HD-DOT provides a compelling alternative that overcomes the significant ergonomic limitations of fMRI and silently images brain function with a wearable cap in a naturalistic setting ideal for studies on awake and engaged infants and toddlers. However, studies in young children over multiple imaging sessions present significant challenges in optical data registration and fidelity that motivate a new set of software tools to enable accurate and reliable mapping of brain function. Here we address these needs by developing novel algorithms for photometric head modeling and data fidelity management. With these advancements, we will conduct a prospective longitudinal study of brain function and behavior in toddlers at risk for developing ASD. Specifically, we will measure neural signatures derived from naturalistic movie viewing, determine the relationship between these signatures and behavioral assays across development, and investigate how these signatures are affected in toddlers at risk for ASD in a case-control sample. These data may provide markers to the specific aspects of impaired behavior observed in ASD, namely affected social communication, receptive and expressive language, motor coordination disruption, and even restricted and repetitive behaviors. Further, this strategy provides a diversified approach to assessment that will be applicable across development, and may facilitate identification of common mechanisms by which disparate genetic pathways to autism result in the broad autistic phenotype.

项目概要/摘要 这些研究的长期目标是推进高密度漫射光学断层扫描（HD-DOT）方法 用于评估有患自闭症谱系障碍风险的婴儿和幼儿的大脑行为关系 （自闭症谱系障碍）当他们醒着并处于自然主义环境中时。该申请正在提交 对 FOA 的回应：RFA-MH-18-200，NIMH 创新新科学家生物行为研究奖 （BRAINS R01），因为 PI 是一名早期研究人员，他正在制定一个高度成熟的研究计划 创新、变革，并有可能阐明潜在机制，为临床提供信息 干预措施，改善自闭症谱系障碍 (ASD) 的结果。因此，这项研究与 NIMH 的使命是一致的： 通过基础和临床研究改变对精神疾病的理解和治疗，为 预防、恢复和治疗的方法。自闭症谱系障碍 (ASD)，定义为社交沟通缺陷和受限 兴趣/重复行为，是一种严重的儿童精神疾病，可以治疗，但目前无法治愈， 估计美国每 59 名儿童中就有 1 人受到影响，估计每年费用为 $268B。早期的 从 18 至 24 个月大时开始的行为和教育干预可以改善部分儿童的结局 患者。神经影像方法，包括基于任务的功能磁共振成像 (fMRI) 和 无任务功能连接 MRI，已证明对自闭症谱系障碍的神经特征敏感，这可能会提供信息 诊断并跟踪干预措施的反应。然而，MRI 环境对于许多人来说可能是无法忍受的 儿童因噪音、幽闭恐惧症以及需要仰卧不动而受到影响。 HD-DOT 提供了引人注目的 克服功能磁共振成像显着的人体工程学限制的替代方案，并通过 在自然环境中佩戴的帽子，非常适合对清醒和参与的婴儿和幼儿进行研究。然而， 对幼儿进行多次成像研究对光学数据配准提出了重大挑战 和保真度激发了一套新的软件工具来实现准确可靠的大脑功能映射。 在这里，我们通过开发用于光度头建模和数据保真度的新颖算法来满足这些需求 管理。凭借这些进展，我们将对大脑功能进行前瞻性纵向研究 有患 ASD 风险的幼儿的行为。具体来说，我们将测量源自 自然主义的电影观看，确定这些特征和行为分析之间的关系 发展，并在病例对照中研究这些特征如何影响有自闭症谱系障碍风险的幼儿 样本。这些数据可以为自闭症谱系障碍中观察到的受损行为的具体方面提供标记，即 影响社交沟通、接受性和表达性语言、运动协调障碍，甚至 限制性和重复性行为。此外，该策略提供了一种多元化的评估方法，将 适用于整个发展，并且可以促进确定不同的共同机制 自闭症的遗传途径导致了广泛的自闭症表型。