Illuminating development of infant and toddler brainfunction with DOT

用 DOT 阐明婴幼儿脑功能的发育

• 批准号: 10553234
• 负责人: Adam Thomas Eggebrecht
• 金额: $ 50.11万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553234
• 关键词: 3-Dimensional; Address; Adult; Affect; Age; Age Months; Algorithms; Anatomy; Auditory; Award; Basic Science; Behavior; Behavior Therapy; Behavior assessment; Behavioral; Behavioral Assay; Behavioral Symptoms; Biological; Brain; Brain Mapping; Brain imaging; Categories; Child; Childhood; Claustrophobias; Clinical; Clinical Research; Clip; Cognitive deficits; Data; Data Set; Development; Diagnosis; Diagnostic; Dimensions; Disparate; Early Diagnosis; Early Intervention; Educational Intervention; Environment; Eye; Functional Magnetic Resonance Imaging; Future; General Population; Genetic; Goals; Head; Heritability; Image; Impairment; Infant; Infant Development; Intervention; Language; Language Delays; Learning; Life; Light; Linear Regressions; Linguistics; Loudness; Magnetic Resonance Imaging; Maps; Measures; Mental disorders; Methodology; Methods; Mission; Modality; Modeling; Monitor; Morphologic artifacts; Motion; Motor; National Institute of Mental Health; Neurocognitive; Neurodevelopmental Disorder; Noise; Optics; Parents; Participant; Pathway interactions; Phenotype; Predisposition; Prevention; Prognosis; Psychopathology; Quality of life; Questionnaires; Recovery; Reporting; Research; Research Personnel; Risk; Risk Marker; Sampling; Scanning; Science; Scientist; Series; Software Tools; Supination; Surface; Techniques; Technology; Temperament; Testing; Therapeutic Intervention; Toddler; United States; Visit; Visual; autism spectrum disorder; autistic; awake; behavior measurement; behavioral impairment; biobehavior; brain behavior; case control; cohort; cost; density; diffuse optical tomography; early childhood; ergonomics; flexibility; functional near infrared spectroscopy; gaze; improved; improved outcome; individual variation; innovation; interest; longitudinal, prospective study; male; movie; neural; neuroimaging; novel; optical imaging; patient subsets; programs; prospective; repetitive behavior; response; social; social communication; social skills; treatment strategy; visual tracking

Project Summary/Abstract The long-term goal of these studies is to advance high-density diffuse optical tomography (HD-DOT) methods for evaluating brain-behavior relationships in infants and toddlers at risk for developing autism spectrum disorder (ASD) while they are awake and engaged within a naturalistic setting. This application is being submitted in response to FOA: RFA-MH-18-200, NIMH Biobehavioral Research Awards for Innovative New Scientists (BRAINS R01), because the PI is an early stage investigator who is building a program of research that is highly innovative, transformative, and has the potential to elucidate underlying mechanisms, inform clinical interventions, and improve outcome of ASD. As such, this research is harmonious with the mission of NIMH: to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. ASD, defined by deficits in social communication and restricted interests/repetitive behaviors, is a serious psychiatric disorder of childhood, is treatable but currently incurable, and affects an estimated 1 in 59 children in the United States at an estimated annual cost of $268B. Early behavioral and educational interventions, starting at 18-24 months of age, improve outcomes in a subset of patients. Neuroimaging methods, including both task-based functional magnetic resonance imaging (fMRI) and task-free functional connectivity MRI, have demonstrated sensitivity to neural signatures of ASD that may inform diagnosis and track responses to interventions. However, the MRI environment can prove intolerable for many children due to noise, claustrophobia, and the need to lie supine and still. HD-DOT provides a compelling alternative that overcomes the significant ergonomic limitations of fMRI and silently images brain function with a wearable cap in a naturalistic setting ideal for studies on awake and engaged infants and toddlers. However, studies in young children over multiple imaging sessions present significant challenges in optical data registration and fidelity that motivate a new set of software tools to enable accurate and reliable mapping of brain function. Here we address these needs by developing novel algorithms for photometric head modeling and data fidelity management. With these advancements, we will conduct a prospective longitudinal study of brain function and behavior in toddlers at risk for developing ASD. Specifically, we will measure neural signatures derived from naturalistic movie viewing, determine the relationship between these signatures and behavioral assays across development, and investigate how these signatures are affected in toddlers at risk for ASD in a case-control sample. These data may provide markers to the specific aspects of impaired behavior observed in ASD, namely affected social communication, receptive and expressive language, motor coordination disruption, and even restricted and repetitive behaviors. Further, this strategy provides a diversified approach to assessment that will be applicable across development, and may facilitate identification of common mechanisms by which disparate genetic pathways to autism result in the broad autistic phenotype.

项目摘要/摘要 这些研究的长期目标是推进高密度弥散光学断层扫描（HD点）方法 用于评估婴儿和幼儿患有自闭症谱系障碍风险的脑行为关系 （ASD）当它们醒着并在自然主义环境中参与其中。此申请正在提交 对FOA的回应：RFA-MH-18-200，NIMH Biobehavioral Research for Innovative新科学家 （Brains R01），因为PI是一名早期阶段调查员，他正在建立一个高度的研究计划 创新，变革性，并有阐明潜在机制的潜力，为临床提供信息 干预措施，并改善ASD的结果。因此，这项研究与NIMH的使命是和谐的： 通过基本和临床研究改变对精神疾病的理解和治疗 预防，恢复和治愈的方法。 ASD，由社会交流中的缺陷定义和受限制 利益/重复行为是一种严重的儿童精神病，是可以治疗但目前无法治愈的， 并影响美国59名儿童中估计有1个，估计每年成本为268B美元。早期的 从18-24个月大的行为和教育干预措施，在一部分 患者。神经影像学方法，包括基于任务的功能磁共振成像（fMRI）和 无任务功能连接性MRI，已经表现出对ASD神经签名的敏感性，可能会告知 诊断和跟踪对干预措施的反应。但是，对于许多人来说，MRI环境可能无法忍受 儿童由于噪音，幽闭恐惧症以及仰卧和静止不动的需要。高清点提供了引人入胜的 克服了fMRI的显着人体工程学局限性和默默地图像脑功能的替代方案 在自然主义环境中可穿戴的帽子非常适合研究清醒和敬业的婴儿和幼儿。然而， 在多个成像课程中对幼儿的研究提出了光学数据注册的重大挑战 和富有促进一套新的软件工具的忠诚度，以实现精确和可靠的大脑功能映射。 在这里，我们通过开发新颖的算法来满足这些需求，用于光度法建模和数据保真度 管理。随着这些进步，我们将对脑功能和 幼儿的行为有发展ASD的风险。具体来说，我们将测量从 自然主义电影观看，确定这些签名与行为分析之间的关系 开发，并调查这些签名如何在病例控制中有ASD风险的幼儿中受到影响 样本。这些数据可能为在ASD中观察到的受损行为的特定方面提供标记，即 影响了社会交流，接受性和表现力的语言，运动协调的破坏，甚至 限制和重复行为。此外，该策略提供了一种多元化的评估方法 在开发中适用，并可能有助于识别常见机制 自闭症的遗传途径导致广泛的自闭症表型。