Illuminating development of infant and toddler brainfunction with DOT

用 DOT 阐明婴幼儿脑功能的发育

• 批准号: 10467604
• 负责人: Adam Thomas Eggebrecht
• 金额: $ 23.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10467604
• 关键词: 3-Dimensional; Address; Adult; Affect; Age; Age-Months; Algorithms; Anatomy; Auditory; Award; Basic Science; Behavior; Behavior Therapy; Behavior assessment; Behavioral; Behavioral Assay; Behavioral Symptoms; Biological; Brain; Brain Mapping; Brain imaging; Child; Childhood; Claustrophobias; Clinical; Clinical Research; Clip; Cognitive deficits; Data; Data Set; Development; Diagnosis; Diagnostic; Dimensions; Early Diagnosis; Early Intervention; Educational Intervention; Environment; Eye; Functional Magnetic Resonance Imaging; Future; General Population; Genetic; Goals; Head; Heritability; Image; Impairment; Infant; Infant Development; Intervention; Language; Language Delays; Learning; Life; Light; Linear Regressions; Linguistics; Longitudinal prospective study; Loudness; Magnetic Resonance Imaging; Maps; Measures; Mental disorders; Methodology; Methods; Mission; Modality; Modeling; Monitor; Morphologic artifacts; Motion; Motor; National Institute of Mental Health; Near-Infrared Spectroscopy; Neurocognitive; Neurodevelopmental Disorder; Noise; Optics; Parents; Participant; Pathway interactions; Phenotype; Predisposition; Prevention; Psychopathology; Quality of life; Questionnaires; Recovery; Reporting; Research; Research Personnel; Risk; Risk Marker; Sampling; Scanning; Science; Scientist; Series; Software Tools; Supination; Surface; Techniques; Technology; Temperament; Therapeutic Intervention; Toddler; United States; Visit; Visual; autism spectrum disorder; autistic; awake; base; behavior measurement; behavioral impairment; biobehavior; brain behavior; case control; cohort; cost; density; diffuse optical tomography; early childhood; flexibility; gaze; improved; improved outcome; individual variation; innovation; interest; male; movie; neuroimaging; novel; optical imaging; patient subsets; predictive test; programs; prospective; relating to nervous system; repetitive behavior; response; social; social communication; social skills; treatment strategy; visual tracking

Project Summary/Abstract The long-term goal of these studies is to advance high-density diffuse optical tomography (HD-DOT) methods for evaluating brain-behavior relationships in infants and toddlers at risk for developing autism spectrum disorder (ASD) while they are awake and engaged within a naturalistic setting. This application is being submitted in response to FOA: RFA-MH-18-200, NIMH Biobehavioral Research Awards for Innovative New Scientists (BRAINS R01), because the PI is an early stage investigator who is building a program of research that is highly innovative, transformative, and has the potential to elucidate underlying mechanisms, inform clinical interventions, and improve outcome of ASD. As such, this research is harmonious with the mission of NIMH: to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. ASD, defined by deficits in social communication and restricted interests/repetitive behaviors, is a serious psychiatric disorder of childhood, is treatable but currently incurable, and affects an estimated 1 in 59 children in the United States at an estimated annual cost of $268B. Early behavioral and educational interventions, starting at 18-24 months of age, improve outcomes in a subset of patients. Neuroimaging methods, including both task-based functional magnetic resonance imaging (fMRI) and task-free functional connectivity MRI, have demonstrated sensitivity to neural signatures of ASD that may inform diagnosis and track responses to interventions. However, the MRI environment can prove intolerable for many children due to noise, claustrophobia, and the need to lie supine and still. HD-DOT provides a compelling alternative that overcomes the significant ergonomic limitations of fMRI and silently images brain function with a wearable cap in a naturalistic setting ideal for studies on awake and engaged infants and toddlers. However, studies in young children over multiple imaging sessions present significant challenges in optical data registration and fidelity that motivate a new set of software tools to enable accurate and reliable mapping of brain function. Here we address these needs by developing novel algorithms for photometric head modeling and data fidelity management. With these advancements, we will conduct a prospective longitudinal study of brain function and behavior in toddlers at risk for developing ASD. Specifically, we will measure neural signatures derived from naturalistic movie viewing, determine the relationship between these signatures and behavioral assays across development, and investigate how these signatures are affected in toddlers at risk for ASD in a case-control sample. These data may provide markers to the specific aspects of impaired behavior observed in ASD, namely affected social communication, receptive and expressive language, motor coordination disruption, and even restricted and repetitive behaviors. Further, this strategy provides a diversified approach to assessment that will be applicable across development, and may facilitate identification of common mechanisms by which disparate genetic pathways to autism result in the broad autistic phenotype.

项目总结/摘要 这些研究的长期目标是推进高密度扩散光学层析成像（HD-DOT）方法 用于评估有自闭症谱系障碍风险的婴幼儿的大脑行为关系 (ASD)而他们是清醒的，并在一个自然的设置从事。本申请是在 响应FOA：RFA-MH-18-200，NIMH生物行为研究奖创新的新科学家 （大脑R 01），因为PI是一个早期阶段的研究者，他正在建立一个高度 创新，变革，并有可能阐明潜在的机制，告知临床 改善ASD的预后。因此，这项研究与NIMH的使命是一致的： 通过基础和临床研究改变对精神疾病的理解和治疗， 预防、恢复和治疗的方法。ASD，定义为社交沟通障碍和 兴趣/重复行为，是一种严重的儿童精神障碍，是可以治疗的，但目前无法治愈， 在美国，每59名儿童中就有1名受到影响，估计每年的费用为2680亿美元。早期 从18-24个月大开始的行为和教育干预，改善了一个子集的结果， 患者神经成像方法，包括基于任务的功能性磁共振成像（fMRI）和 无任务功能连接MRI，已经证明了对ASD神经特征的敏感性， 诊断和跟踪对干预措施的反应。然而，MRI环境可能对许多人来说是无法忍受的。 儿童由于噪音，幽闭恐怖症，需要仰卧和静止。HD-DOT提供了一个引人注目的 一种替代方案，克服了功能性磁共振成像的重大人体工程学限制，并无声地成像大脑功能， 可佩戴的帽子，在自然主义的设置理想的研究清醒和从事婴儿和幼儿。然而，在这方面， 在幼儿中进行的多次成像研究在光学数据配准方面提出了重大挑战 和保真度，激发了一套新的软件工具，使大脑功能的准确和可靠的映射。 在这里，我们通过开发用于光度头建模和数据保真度的新算法来满足这些需求 管理有了这些进展，我们将对大脑功能进行前瞻性纵向研究， 有患自闭症风险的幼儿的行为。具体来说，我们将测量来自于 自然主义的电影观看，确定这些签名和行为测定之间的关系， 发展，并调查这些签名是如何影响幼儿在ASD的风险，在病例对照 sample.这些数据可以为在ASD中观察到的受损行为的特定方面提供标记，即 影响社会沟通，接受和表达语言，运动协调中断，甚至 限制和重复的行为。此外，这一战略提供了一种多样化的评估方法， 适用于整个开发过程，并可能有助于确定不同的 自闭症的遗传途径导致广泛的自闭症表型。