COBRE Center for Neuromodulation (CCN)

项目总结 科布雷神经调节中心(CCN)将设在巴特勒医院，这是一家独立的精神病院 和布朗大学阿尔伯特医学院附属的神经精神病院。这个Cobre会 创建关键基础设施并支持跨学科调查人员核心小组建立一个自我维持的 临床-转化脑研究的卓越中心。它的总体目标是促进非侵入性 神经精神障碍环路治疗中的神经调节。 这个应用程序汇集了三名非常有前途的初级调查人员，他们将使用 无创脑刺激(经颅磁刺激和经颅电刺激)和神经成像 工具(结构和功能磁共振)。他们将共同致力于大脑回路的临床翻译研究。 与疾病的症状和维度有关的。他们感兴趣的领域是冲动行为、创伤后应激障碍和 强迫症(OCD)。使用在该组织内工作的经验丰富、技能高超的导师 作为行政核心，CCN将把这些有才华的年轻研究人员的职业生涯推向 更高水平的研究独立性。 CCN将支持两个新的研究核心：设计和分析核心(DAC)和神经成像 和巴特勒医院的神经调节核心(NNC)。这些核心将提供所需的基本基础设施 成功地开展每个项目。这包括统计和方法咨询以及专门知识。 需要设计和分析建议的研究(DAC)以及设备、技术支持和专业知识 刺激实施和获取神经成像数据(NNC)所必需的。 行政核心还将支持与我们的神经翻译研究主题相关的试点拨款 电路和疾病。这些奖助金将在中心的第二至第五年每年颁发一次。 CCN将把巴特勒医院打造成这一令人兴奋的转化医学领域的全国领先者， 将扩大无创脑刺激跨脑和脑疾病的研究和临床应用 行为。它将统一神经精神疾病临床-翻译研究中的跨学科社区， 为了患者的最终利益。

PROJECT SUMMARY The COBRE Center for Neuromodulation (CCN) will be centered at Butler Hospital, a freestanding psychiatric and neuropsychiatric hospital affiliated with the Alpert Medical School at Brown University. This COBRE will create key infrastructure and support a core group of interdisciplinary investigators to build a self-sustaining center of excellence in clinical-translational brain research. Its overall goal is to advance the use of noninvasive neuromodulation in circuit-based therapies for neuropsychiatric disorders. This application brings together three highly promising junior investigators, who will use methods of noninvasive brain stimulation (transcranial magnetic and transcranial electrical stimulation) and neuroimaging tools (structural and functional MRI). They will work together on clinical-translational research on brain circuits relating to symptoms and dimensions of illness. Their areas of interest are impulsive behavior, PTSD, and obsessive-compulsive disorder (OCD). Using experienced, highly skilled mentors working within the structure of an Administrative Core, the CCN will advance the careers of these talented young researchers towards the next level of research independence. The CCN will support two new research cores: the Design and Analysis Core (DAC) and the Neuroimaging and Neuromodulation Core (NNC) at Butler Hospital. These cores will provide essential infrastructure needed to successfully carry out each project. This includes statistical and methodological consultation and expertise needed to design and analyze the studies proposed (DAC), and equipment, technical support, and expertise necessary for stimulation implementation and acquisition of neuroimaging data (NNC). The Administrative Core will also support pilot grants relating to our theme of translational research in neural circuits and disease. These grants will be awarded yearly in years 2 to 5 of the Center. The CCN will establish Butler Hospital as a national leader in this exciting field of translational medicine, which will expand research and clinical application of noninvasive brain stimulation across disorders of brain and behavior. It will unify an interdisciplinary community in clinical-translational research of neuropsychiatric illness, for the ultimate benefit of patients.