VA RR&D Center for Neurorestoration and Neurotechnology

VARR

• 批准号: 10536571
• 负责人: BENJAMIN D GREENBERG
• 金额: --
• 依托单位: PROVIDENCE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10536571
• 关键词: Affect; Amputation; Amyotrophic Lateral Sclerosis; Area; Brain; Brain Diseases; Clinical; Clinical Research; Clinical Trials; Communication; Communities; Data; Dedications; Devices; Disease; Early Diagnosis; Education; Engineering; Epilepsy; Family; Funding; Goals; Health; Healthcare Systems; Hospitals; Human; Impairment; Infrastructure; Injury; Interdisciplinary Study; Internships; Intuition; Investments; Knowledge; Learning; Leg; Limb structure; Medical Device; Mental Depression; Mental Health; Mental disorders; Nervous System; Neurologic; Neuropsychology; Neurosciences; Obsessive-Compulsive Disorder; Outcome Measure; Peer Review; Persons; Pilot Projects; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Privatization; Productivity; Rehabilitation therapy; Research; Research Personnel; Research Project Grants; Resources; Science; Scientist; Seizures; Sensory; Services; Shapes; Spinal cord injury; Strategic Planning; Stroke; Testing; Therapeutic; Training; Translating; Translational Research; Universities; Veterans; arm; career; clinical practice; computational neuroscience; design; graduate student; improved; limb loss; military service; multidisciplinary; nervous system disorder; neuroimaging; neurorestoration; neurotechnology; novel; novel diagnostics; recruit; undergraduate student

The VA RR&D Center for Neurorestoration and Neurotechnology (CfNN) at the Providence VA Healthcare System (VAPHS) unifies a distinguished team of scientists, engineers and clinicians from the VA, Brown University, and affiliated hospitals to discover, design, develop, and deploy novel neurotechnologies and device-based therapies that advance the rehabilitation of Veterans with impairments in mobility, communication, mental health, and limb function. CfNN’s three Focus Areas are each dedicated to performing the rigorous, peer-reviewed science that leads to new diagnostic, rehabilitation, and therapeutic strategies for Veterans with spinal cord injury, stroke, amyotrophic lateral sclerosis (ALS), epilepsy, limb loss, post-traumatic stress disorder (PTSD), depression, and other nervous system diseases or injuries. CfNN’s three Focus Areas are: (1) Restoring Communication and Mobility, (2) Restoring Mental Health, and (3) Restoring Limb and Sensory Function. The Focus Areas’ interdisciplinary research efforts are supported by three Cores providing essential infrastructure and specialized services: (A) Neuroimaging (B) Recording, Decoding, and Computational Neuroscience, and (C) Assessment, Outcome Measurement, and Implementation. CfNN research is further facilitated by a dedicated Administrative Team who support scientific productivity, coordinate the synergistic relationships between CfNN and its academic and clinical affiliates, maintain close contact with local and national VA officials, and optimize our research in service to Veterans. CfNN’s Strategic Plan and Research Strategy maximize interactions via complementary expertise and resources among its Focus Areas and Cores. This in turn supports a high-impact research community focused on application of medical devices to neurologic health, both within the VA and in the wider regional and national brain science community. Through this renewal, over the next five years CfNN will leverage and expand its collaborative research, both within VA Providence and together with other VA Centers, toward rehabilitation goals important to the large number of affected Veterans and their families. These goals include: restoring arm and leg function for Veterans with stroke, spinal cord injury, or amputation; improving and maintaining intuitive, rapid communication for Veterans with ALS; improving the understanding, early detection, and management of seizures; and more effectively treating Veterans with PTSD, depression, obsessive-compulsive disorder, or other severe disorders of mental health. CfNN also aims to develop, validate, and disseminate the outcomes measures needed for effective clinical trials of new restorative neurotechnologies for these conditions. In addition to the research of its investigators, CfNN facilitates the training and research careers of outstanding early career researchers, seeking to recruit them together with established clinicians, scientists, and engineers to focus their research efforts on improving rehabilitation for Veterans with nervous system disease or injury. CfNN is committed to providing seed funding for pilot studies to enable affiliated investigators to launch promising research and collect preliminary data to inform and strengthen larger research projects, thereby strategically leveraging VA resources toward enabling the larger public and private investments required for pivotal demonstrations of clinical utility. Through its close association with Brown University, CfNN provides educational opportunities to undergraduates, graduate students, neuropsychology interns, and postdoctoral researchers to learn more about the VA, inspiring them to shape their careers toward not only gaining a better understanding of fundamental human neuroscience, but toward using that knowledge to improve Veterans Health and rehabilitation.

弗吉尼亚州普罗维登斯的VA RR&D神经修复和神经技术中心（CfNN） 医疗保健系统（VAPHS）联合了来自世界各地的杰出科学家，工程师和临床医生团队， 弗吉尼亚州，布朗大学和附属医院发现，设计，开发和部署新的 神经技术和基于设备的治疗，促进退伍军人的康复， 行动能力、沟通能力、心理健康和肢体功能受损。CfNN的三个重点领域是 每一个致力于执行严格的，同行评审的科学，导致新的诊断， 脊髓损伤、脑卒中、肌萎缩侧索硬化、脊髓损伤、 硬化症（ALS）、癫痫、肢体丧失、创伤后应激障碍（PTSD）、抑郁症等 神经系统疾病或损伤。CfNN的三个重点领域是：（1）恢复沟通， 活动能力，（2）恢复心理健康，（3）恢复肢体和感觉功能。重点领域“ 跨学科研究工作得到三个核心的支持，提供必要的基础设施， 专业服务：（A）神经成像（B）记录、解码和计算神经科学，以及 (C)评估、结果衡量和实施。CfNN研究进一步促进了一个 专门的行政团队，支持科学生产力，协调协同 CfNN与其学术和临床分支机构之间的关系，与当地和 国家退伍军人事务部官员，并优化我们的研究，为退伍军人服务。CfNN的战略计划和 研究战略通过其重点之间的互补专业知识和资源最大限度地发挥互动作用 区域和核心。这反过来又支持了一个高影响力的研究社区，专注于应用 医疗设备的神经健康，无论是在VA和更广泛的区域和国家的大脑 科学界。通过此次续约，在未来五年内，CfNN将利用并扩大其 合作研究，无论是在弗吉尼亚州普罗维登斯，并与其他VA中心， 康复目标对大量受影响的退伍军人及其家人很重要。这些目标 包括：恢复中风、脊髓损伤或截肢退伍军人的手臂和腿部功能; 改善和保持直观，快速沟通的退伍军人与ALS;改善 了解，早期发现和管理癫痫发作;更有效地治疗退伍军人 患有创伤后应激障碍、抑郁症、强迫症或其他严重的心理健康障碍。 CfNN还旨在开发，验证和传播有效实施所需的结果措施。 临床试验的新恢复神经技术为这些条件。除了研究其 调查员，CfNN促进优秀的早期职业研究人员的培训和研究生涯， 寻求招募他们与既定的临床医生，科学家和工程师一起， 研究努力改善退伍军人神经系统疾病或损伤的康复。CfNN是 致力于为试点研究提供种子资金，使附属研究人员能够启动 有前途的研究和收集初步数据，为更大的研究项目提供信息和加强， 从而战略性地利用退伍军人事务资源，使更多的公共和私人投资成为可能 临床实用性的关键演示所需的。通过与布朗大学的密切联系， CfNN为本科生，研究生，神经心理学， 实习生和博士后研究人员更多地了解VA，激励他们塑造自己的职业生涯 不仅是为了更好地理解基本的人类神经科学， 这些知识，以改善退伍军人的健康和康复。

项目成果

Suicidal thoughts and behaviours among military veterans: protocol for a prospective, observational, neuroimaging study.

• DOI: 10.1136/bmjopen-2022-070654
• 发表时间: 2023-08-16
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Namaky, Nauder;Swearingen, Hannah R.;Winter, Jake;Bozzay, Melanie;Primack, Jennifer M.;Philip, Noah S.;Barredo, Jennifer
• 通讯作者: Barredo, Jennifer

Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder: Prevention in the Context of New Trauma.

经颅磁刺激治疗创伤后应激障碍：新创伤背景下的预防。

• 发表时间: 2023
• 期刊: Rhode Island medical journal (2013)
• 作者: Brennan,McKennaC;Philip,NoahS
• 通讯作者: Philip,NoahS

Transcranial direct current stimulation impairs updating of avoidance-based associative learning.

• DOI: 10.3389/fnhum.2023.1104614
• 发表时间: 2023
• 期刊: Frontiers in human neuroscience
• 影响因子: 2.9

Power-saving design opportunities for wireless intracortical brain-computer interfaces.

• DOI: 10.1038/s41551-020-0595-9
• 发表时间: 2020-10
• 期刊: Nature biomedical engineering
• 影响因子: 28.1
• 作者: Even-Chen N;Muratore DG;Stavisky SD;Hochberg LR;Henderson JM;Murmann B;Shenoy KV
• 通讯作者: Shenoy KV

Combined transcranial direct current stimulation with virtual reality exposure for posttraumatic stress disorder: Feasibility and pilot results.

• DOI: 10.1016/j.brs.2018.09.011
• 发表时间: 2019-01
• 期刊: Brain stimulation
• 影响因子: 7.7
• 作者: van 't Wout-Frank M;Shea MT;Larson VC;Greenberg BD;Philip NS
• 通讯作者: Philip NS