COBRE Center for Neuromodulation (CCN)

COBRE 神经调节中心 (CCN)

• 批准号: 10372249
• 负责人: BENJAMIN D GREENBERG
• 金额: $ 38.18万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10372249
• 关键词: Address; Area; Award; Base of the Brain; Behavioral; Brain; Brain Diseases; Centers of Research Excellence; Clinical; Clinical Psychology; Clinical Research; Clinical Trials; Collaborations; Communities; Consultations; Data; Data Analytics; Development; Diagnosis; Dimensions; Disease; Electric Stimulation; Engineering; Equipment; Experimental Designs; Extinction (Psychology); Fright; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Grant; Growth; Hospitals; Impairment; Impulsive Behavior; Impulsivity; Infrastructure; Investigation; Learning; Link; Magnetism; Measures; Memory; Mentors; Mentorship; Methodology; Methods; Modeling; Monitor; Neuropsychology; Obsessive-Compulsive Disorder; Outcome; Patients; Pharmacological Treatment; Pilot Projects; Population; Post-Traumatic Stress Disorders; Program Evaluation; Protocols documentation; Research; Research Personnel; Resources; Rhode Island; Safety; Scientist; Structure; Symptoms; Talents; Technical Expertise; Testing; Translational Research; Universities; Work; base; brain behavior; brain research; career; career development; clinical application; clinical efficacy; clinical implementation; clinically relevant; cognitive neuroscience; data acquisition; design; experience; innovation; insight; interest; medical schools; multidisciplinary; neural circuit; neuroimaging; neuropsychiatric disorder; neuropsychiatry; neuroregulation; noninvasive brain stimulation; novel; programs; recruit; skill acquisition; synergism; tool; translational medicine; years lived with disability; young adult

PROJECT SUMMARY The COBRE Center for Neuromodulation (CCN) will be centered at Butler Hospital, a freestanding psychiatric and neuropsychiatric hospital affiliated with the Alpert Medical School at Brown University. This COBRE will create key infrastructure and support a core group of interdisciplinary investigators to build a self-sustaining center of excellence in clinical-translational brain research. Its overall goal is to advance the use of noninvasive neuromodulation in circuit-based therapies for neuropsychiatric disorders. This application brings together three highly promising junior investigators, who will use methods of noninvasive brain stimulation (transcranial magnetic and transcranial electrical stimulation) and neuroimaging tools (structural and functional MRI). They will work together on clinical-translational research on brain circuits relating to symptoms and dimensions of illness. Their areas of interest are impulsive behavior, PTSD, and obsessive-compulsive disorder (OCD). Using experienced, highly skilled mentors working within the structure of an Administrative Core, the CCN will advance the careers of these talented young researchers towards the next level of research independence. The CCN will support two new research cores: the Design and Analysis Core (DAC) and the Neuroimaging and Neuromodulation Core (NNC) at Butler Hospital. These cores will provide essential infrastructure needed to successfully carry out each project. This includes statistical and methodological consultation and expertise needed to design and analyze the studies proposed (DAC), and equipment, technical support, and expertise necessary for stimulation implementation and acquisition of neuroimaging data (NNC). The Administrative Core will also support pilot grants relating to our theme of translational research in neural circuits and disease. These grants will be awarded yearly in years 2 to 5 of the Center. The CCN will establish Butler Hospital as a national leader in this exciting field of translational medicine, which will expand research and clinical application of noninvasive brain stimulation across disorders of brain and behavior. It will unify an interdisciplinary community in clinical-translational research of neuropsychiatric illness, for the ultimate benefit of patients.

项目摘要 COBRE神经调节中心（CCN）将集中在巴特勒医院，一个独立的精神病 和布朗大学阿尔珀特医学院附属的神经精神病医院。这个眼镜蛇 建立关键的基础设施，并支持一个跨学科研究人员的核心小组，以建立一个自我维持的 临床转化脑研究卓越中心。其总体目标是推进非侵入性 神经调节在神经精神疾病的基于回路的治疗中的应用。 这个应用程序汇集了三个非常有前途的初级调查员，他们将使用的方法， 非侵入性脑刺激（经颅磁刺激和经颅电刺激）和神经成像 结构和功能MRI（Structural and Functional MRI）他们将共同致力于大脑回路的临床转化研究 与疾病的症状和范围有关。他们感兴趣的领域是冲动行为，创伤后应激障碍， 强迫症（OCD）。使用经验丰富，技能高超的导师在结构内工作 作为一个行政核心，CCN将推动这些有才华的年轻研究人员的职业生涯， 更高层次的研究独立性。 CCN将支持两个新的研究核心：设计和分析核心（DAC）和神经成像 和神经调节核心（NNC）在巴特勒医院。这些核心将提供必要的基础设施 成功实施每一个项目。这包括统计和方法方面的咨询和专门知识 设计和分析拟议研究所需的设备、技术支持和专业知识 刺激实施和神经成像数据（NNC）采集所必需的。 行政核心还将支持与我们的神经系统转化研究主题有关的试点赠款。 电路和疾病。这些赠款将在中心的第2年至第5年每年颁发。 CCN将把巴特勒医院建立为转化医学这一令人兴奋的领域的国家领导者， 将扩大非侵入性脑刺激的研究和临床应用， 行为它将在神经精神疾病的临床转化研究中统一一个跨学科社区， 最终造福患者。