ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

加强CALERIE网络促进衰老生物学 摘要： 直接响应PA-20-071，研究基础设施的高级阶段开发和使用 跨学科老龄化研究)，我们建议加强和发展CALERIE研究网络，使其成为一个自我 支持样本、数据和老化的生物学研究人员的基础结构。综合测评 减少能量摄入的长期影响(CALERIE)是一项随机对照试验，旨在 评估在没有强制改变饮食的情况下持续两年热量限制对人类的影响 组成。总的目标是阐明潜在的生物学机制和介体。 人类的原发和继发性衰老。CALERIE干预的严谨设计与实施 产生了无价的资源，包括与生物学相关的全面的表型数据 样本。为了确保这些样本和数据的持续使用，我们描述了一项计划，以创建一个自我维持的 CALERIE网络。我们的目标是通过加强1)利用，2)开发来推进衰老研究 以及CALERIE研究网络的跨学科发展。CALERIE资源的利用将是 由指导委员会、NIA生物库代表、NIA支持的网络推动和管理 和中心、年度讲习班和工作组。这些努力将确保最好地利用剩余的CALERIE 样本以及将新数据纳入复杂的多层次数据库。CALERIE网络间 将通过吸引新的和初级的老年生物学家来试点项目、职业生涯来促进学科发展 开发活动，以及丰富的综合系统生物学项目。通过开发更多 调查人员、项目和学科，新的数据和样本将被生成，并将使老化永久化 生物科学循环。因此，完成这些目标应该产生一个成熟的、可持续的基础设施， 维护和监督CALERIE样本和数据，保持CALERIE辅助集成 研究，并有助于全面提高对人类衰老生物学的理解。

ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY ABSTRACT: In direct response to PA-20-071, Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies), we propose to enhance and grow the CALERIE Research Network into a self- sustaining infra-structure of samples, data, and aging biology investigators. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) was a randomized controlled trial designed to assess the effects in humans of two years of sustained caloric restriction without enforced changes of dietary composition. The overall objective was to elucidate underlying biological mechanisms and mediators of primary and secondary human aging. The rigorous design and execution of the CALERIE intervention produced an invaluable resource, including comprehensive phenotypic data that are coupled to biological samples. To ensure continued use of these samples and data, we describe a plan to create a self-sustained CALERIE Network. Our aims are to advance aging research through enhanced 1) utilization, 2) development and interdisciplinary growth of the CALERIE Research Network. Utilization of CALERIE resources will be promoted and stewarded by a Steering Committee, an NIA Biobank representative, NIA-supported Networks and Centers, annual workshops and working groups. These efforts will ensure best use of remaining CALERIE samples as well as incorporation of new data into a complex multi-level database. CALERIE Network inter- disciplinary growth will be fostered by attracting new and junior aging biologists to pilot projects, career development activities, and a rich pipeline of integrative systems biology projects. By developing more investigators, projects, and disciplines, new data and samples will be generated and will perpetuate the aging biology scientific cycle. Thus, completion of these aims should yield a mature, sustainable infrastructure that maintains and oversees CALERIE samples and data, perpetuates CALERIE ancillary integrative investigations, and contributes to overall advancement of understanding of human aging biology.