ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

加强 CALERIE 网络以推进衰老生物学

• 批准号: 10584573
• 负责人: KIM M. HUFFMAN
• 金额: $ 64.29万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10584573
• 关键词: Address; Age; Aging; Ancillary Study; Area; Biological; Biological Process; Biology of Aging; Caloric Restriction; Calories; Capsicum; Caring; Clinical Research; Collaborations; Complex; Coupled; Data; Databases; Development; Discipline; Drug Targeting; Eating; Educational workshop; Energy Intake; Ensure; Epigenetic Process; Fellowship; Fostering; Funding; Genetic; Grant; Growth; Health; Human; Infrastructure; Insecta; Intake; Intervention; Investigation; Knowledge; Long-Term Effects; Longevity; Maintenance; Mediator; Organ; Organism; Persons; Pilot Projects; Process; Proteomics; Publications; Randomized; Randomized, Controlled Trials; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Review Committee; Rodent; Sampling; Scholars Program; System; Systems Biology; Tissues; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; Yeasts; biobank; career development; complex data; data integration; data repository; design; dietary; experience; interdisciplinary collaboration; member; metabolomics; nonhuman primate; phenotypic data; programs; repository; response; secondary analysis; support network; transcriptomics; trial design; web site; working group

ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY ABSTRACT: In direct response to PA-20-071, Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies), we propose to enhance and grow the CALERIE Research Network into a self- sustaining infra-structure of samples, data, and aging biology investigators. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) was a randomized controlled trial designed to assess the effects in humans of two years of sustained caloric restriction without enforced changes of dietary composition. The overall objective was to elucidate underlying biological mechanisms and mediators of primary and secondary human aging. The rigorous design and execution of the CALERIE intervention produced an invaluable resource, including comprehensive phenotypic data that are coupled to biological samples. To ensure continued use of these samples and data, we describe a plan to create a self-sustained CALERIE Network. Our aims are to advance aging research through enhanced 1) utilization, 2) development and interdisciplinary growth of the CALERIE Research Network. Utilization of CALERIE resources will be promoted and stewarded by a Steering Committee, an NIA Biobank representative, NIA-supported Networks and Centers, annual workshops and working groups. These efforts will ensure best use of remaining CALERIE samples as well as incorporation of new data into a complex multi-level database. CALERIE Network inter- disciplinary growth will be fostered by attracting new and junior aging biologists to pilot projects, career development activities, and a rich pipeline of integrative systems biology projects. By developing more investigators, projects, and disciplines, new data and samples will be generated and will perpetuate the aging biology scientific cycle. Thus, completion of these aims should yield a mature, sustainable infrastructure that maintains and oversees CALERIE samples and data, perpetuates CALERIE ancillary integrative investigations, and contributes to overall advancement of understanding of human aging biology.

增强卡其度网络以推动老化生物学 抽象的： 在对PA-20-071的直接响应中，研究基础设施的高级发展和利用 跨学科的衰老研究），我们建议将Calerie Research网络增强和发展为自我 维持样品，数据和衰老生物学研究者的基础结构。全面评估 减少能源摄入（Calerie）的长期影响是一项随机对照试验，旨在 评估两年持续热量限制的人类的影响，而无需进行饮食的变化 作品。总体目的是阐明基本的生物学机制和介体 初级和次要人类衰老。热门干预的严格设计和执行 产生了宝贵的资源，包括与生物学结合的综合表型数据 样品。为了确保继续使用这些样本和数据，我们描述了一个计划，以创建一个自我维持的计划 热门网络。我们的目的是通过增强来提高衰老研究1）利用率，2）开发 和卡尔研究网络的跨学科增长。使用热量资源将是 由指导委员会促进和管理，NIA生物库代表，由NIA支持的网络 和中心，年度研讨会和工作组。这些努力将确保最佳使用剩余的热量 样本以及将新数据合并到复杂的多级数据库中。热量网络间 通过吸引新的和初级老化的生物学家从事试点项目，职业生涯，将促进纪律增长 开发活动和综合系统生物学项目的丰富管道。通过开发更多 研究人员，项目和学科，新数据和样本将被生成，并将延续老化 生物学科学周期。因此，这些目标的完成应产生一个成熟，可持续的基础设施 维护和监督热量样品和数据，使其永久加固辅助辅助综合 调查，并有助于对人衰老生物学的理解的整体发展。