ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

加强Calerie网络以促进衰老生物学 摘要： 直接响应PA-20-071，研究基础设施的高级开发和利用， 跨学科老龄化研究），我们建议加强和发展CALERIE研究网络成为一个自我， 维持样本、数据和老化生物学研究人员的基础设施。综合考核 减少能量摄入的长期效应（CALERIE）是一项随机对照试验， 评估在不强制改变饮食的情况下持续两年的热量限制对人类的影响 混合物.总体目标是阐明潜在的生物学机制和介质， 第一次和第二次人类衰老CALERIE干预的严格设计和执行 产生了一个宝贵的资源，包括全面的表型数据，这是耦合到生物 样品为了确保这些样本和数据的持续使用，我们描述了一个计划，以创建一个自我维持的 Network.我们的目标是通过提高1）利用率，2）开发 CALERIE研究网络的跨学科发展。CALERIE资源的利用将 由指导委员会、NIA生物库代表、NIA支持的网络 中心、年度讲习班和工作组。这些努力将确保最好地利用剩余的CALERIE 样本以及新的数据纳入一个复杂的多级数据库。CALERIE网络 学科的发展将通过吸引新的和初级的老龄生物学家到试点项目，职业生涯 开发活动，以及丰富的综合系统生物学项目管道。通过开发更 研究人员，项目和学科，新的数据和样本将产生，并将延续老化 生物科学循环因此，完成这些目标应产生一个成熟的，可持续的基础设施， 维护和监督CALERIE样品和数据，使CALERIE辅助综合 研究，并有助于人类衰老生物学的整体进步的理解。

ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY ABSTRACT: In direct response to PA-20-071, Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies), we propose to enhance and grow the CALERIE Research Network into a self- sustaining infra-structure of samples, data, and aging biology investigators. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) was a randomized controlled trial designed to assess the effects in humans of two years of sustained caloric restriction without enforced changes of dietary composition. The overall objective was to elucidate underlying biological mechanisms and mediators of primary and secondary human aging. The rigorous design and execution of the CALERIE intervention produced an invaluable resource, including comprehensive phenotypic data that are coupled to biological samples. To ensure continued use of these samples and data, we describe a plan to create a self-sustained CALERIE Network. Our aims are to advance aging research through enhanced 1) utilization, 2) development and interdisciplinary growth of the CALERIE Research Network. Utilization of CALERIE resources will be promoted and stewarded by a Steering Committee, an NIA Biobank representative, NIA-supported Networks and Centers, annual workshops and working groups. These efforts will ensure best use of remaining CALERIE samples as well as incorporation of new data into a complex multi-level database. CALERIE Network inter- disciplinary growth will be fostered by attracting new and junior aging biologists to pilot projects, career development activities, and a rich pipeline of integrative systems biology projects. By developing more investigators, projects, and disciplines, new data and samples will be generated and will perpetuate the aging biology scientific cycle. Thus, completion of these aims should yield a mature, sustainable infrastructure that maintains and oversees CALERIE samples and data, perpetuates CALERIE ancillary integrative investigations, and contributes to overall advancement of understanding of human aging biology.