Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities

急性护理研究可以定义为对预防、治疗、康复或姑息治疗的研究 行动取决于对时间敏感和紧急的干预。因此，急性护理涵盖多种医疗 专业，包括重症监护服务、急诊和紧急护理、创伤和急症护理手术，以及 神经重症监护。在农村州，需要改进急症护理和急症护理研究 由于医疗进步加大了城乡之间的差距，这一问题迫在眉睫。这些 差异在很大程度上是由于获得经过专业培训的临床医生、资源和设施的不平衡造成的， 以及临床研究。我们提议建立一个新的跨部门生物医学研究卓越中心 (COBRE) 位于缅因州医疗中心，这是一家三级护理中心，位于缅因州最大的人口中心（波特兰） 缅因州。作为活动中心，该计划将指导一批急症护理研究人员 在重要的临床/转化领域需要，同时为这些研究的影响提供基础 我们州所有地区的社区和患者。该 COBRE 由医学博士 Douglas Sawyer 领导，他是 在临床护理服务、指导和转化研究方面确立了领先地位。该计划的目标 是： 1) 提供领导、治理和咨询网络，以建立急症护理领域的 COBRE 缅因州医疗中心的研究和农村差异； 2) 提供项目启动和指导支持 该科学计划中有前途的临床科学家的职业生涯，并帮助确保他们的长期 作为独立研究人员取得的科学成功； 3）增强缅因州医疗中心核心能力 设施和研究基础设施，以支持我们的 COBRE 研究人员和 其他机构和外部研究人员，并刺激创新的研究方法和新的 合作，以及 4) 加强我们现有的 COBRE 和 CTR 支持的试点项目计划，重点关注 与急症护理和农村健康差异相关的转化和临床机会。在第一阶段，我们有 初步选定了4名具有首要需求的临床研究领域的临床/转化项目负责人。这些 包括：Teresa May DO，一位重症监护医师兼研究员，正在开发标准化的全州范围系统 心脏骤停复苏后护理，David Gagnon 药学博士，一位药剂师兼研究员，正在测试以下方法的益处 心脏骤停幸存者中的预防性抗生素，David Seder MD，重症监护医师兼研究员 扩大了他的临床研究计划，将炎症的转化分子信号研究纳入其中 心脏骤停和儿科神经学家 Alexa Craig MD 从事利用远程医疗的研究 改善出生时有脑病风险的新生儿的生存率和神经系统结果。这些研究人员 将得到强大的指导和咨询网络以及社区参与、生物伦理学和 外展核心将在学习中发展全州范围内的卫生专业人员和社区伙伴关系 医疗保健系统，以增强对人类受试者研究的理解并增加其包容性。

Acute care research can be defined as investigations into preventive, curative, rehabilitative, or palliative actions that depend on time-sensitive and urgent intervention. Thus, acute care encompasses multiple medical specialties, including critical care services, emergency and urgent care, trauma and acute care surgery, and neurocritical care. In rural states, the need for improvements in acute care and acute care research are pressing, as medical advances have increased the disparities between urban and rural areas. These disparities are due in large part to imbalances in access to specialty-trained clinicians, resources and facilities, as well as clinical research. We propose a new inter-departmental Center for Biomedical Research Excellence (COBRE) at Maine Medical Center, a tertiary care center located in the largest population center (Portland) in the state of Maine. Serving as the hub of activities, this program will mentor cohorts of acute care researchers in significant clinical/translational areas of need while providing a foundation for these studies to impact communities and patients in all regions of our state. This COBRE is led by Douglas Sawyer MD, PhD, an established leader in clinical care services, mentorship, and translational research. The aims of this program are: 1) Provide the leadership, governance, and advisory network to establish a COBRE in Acute Care Research and Rural Disparities at Maine Medical Center; 2) Provide project and mentorship support to launch the careers of promising clinician-scientists within this scientific program, and help ensure their long-term scientific success as independent researchers; 3) Enhance the capabilities of Maine Medical Center's core facilities and research infrastructure to support human subject research of both our COBRE investigators and other institutional and external researchers, and to stimulate innovative research methodologies and new collaborations, and 4) Enhance our existing COBRE- and CTR-supported pilot project programs to focus on translational and clinical opportunities related to acute care and rural health disparities. In Phase I, we have initially selected 4 clinical/translational project leaders with clinical research areas of primary need. These include: Teresa May DO, a critical care physician-researcher developing a standardized statewide system of cardiac arrest post-resuscitation care, David Gagnon PharmD, a pharmacist-researcher testing the benefits of prophylactic antibiotics in cardiac arrest survivors, David Seder MD, a critical care physician-researcher expanding his clinical research program to include translational molecular signaling studies of inflammation in cardiac arrest, and Alexa Craig MD, a pediatric neurologist engaged in research utilizing telemedicine to improve survival and neurological outcomes for newborns born at risk for encephalopathy. These researchers will be supported by a robust mentorship and advisory network and a Community Engagement, Bioethics, and Outreach Core that will develop state-wide health professional and community partnerships in a learning healthcare system to enhance understanding of and increase inclusion in human subjects research.