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Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities

急性护理研究和农村差异生物医学卓越研究中心

基本信息

批准号：
10558700
负责人：
Douglas B Sawyer
金额：
$ 255.58万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-10 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10558700
关键词：
Acute Address Adult Antibiotic Prophylaxis Antibiotics Area Bioethics Caring Center for Translational Science Activities Centers of Research Excellence Childhood Clinical Clinical Research Collaborations Communities Consent Core Facility Critical Care Development Disadvantaged Disparity Doctor of Pharmacy Doctor of Philosophy Emergency Care Emergency Situation Emergency medical service Encephalopathies Ensure Event Foundations Funding Future Goals Health Professional Healthcare Systems Heart Arrest Human Subject Research Hypoxia Inflammation Infrastructure Injury Institution Intervention Investigation Leadership Learning Longevity Maine Medical Medical center Mentors Mentorship Methods Molecular Neurological outcome Neurologist Newborn Infant Operative Surgical Procedures Outcome Patient-Focused Outcomes Patients Pharmacists Phase Physicians Pilot Projects Pneumonia Population Preventive Process Protocols documentation Reduce health disparities Rehabilitation therapy Research Research Infrastructure Research Institute Research Methodology Research Personnel Research Support Resources Resuscitation Risk Rural Rural Community Rural Health Rural Population Scientist Services Signal Transduction Site Standardization Survivors System Technology Telemedicine Testing Time Training Translational Research Travel United States National Institutes of Health Variant acute care care delivery care systems career clinical care clinical infrastructure cohort community engagement community involvement community partnership design disparity reduction diversity and inclusion experience health care disparity immunoregulation improved improved outcome innovation medical specialties neonatal hypoxic-ischemic brain injury neonate neuroprotection novel novel therapeutics outreach palliative prevent programs prophylactic research study response rural area rural disparities rural health disparities rural patients rurality success survival outcome synergism teleconsent tertiary care tool translational research program trauma care urban area urgent care

项目摘要

Acute care research can be defined as investigations into preventive, curative, rehabilitative, or palliative actions that depend on time-sensitive and urgent intervention. Thus, acute care encompasses multiple medical specialties, including critical care services, emergency and urgent care, trauma and acute care surgery, and neurocritical care. In rural states, the need for improvements in acute care and acute care research are pressing, as medical advances have increased the disparities between urban and rural areas. These disparities are due in large part to imbalances in access to specialty-trained clinicians, resources and facilities, as well as clinical research. We propose a new inter-departmental Center for Biomedical Research Excellence (COBRE) at Maine Medical Center, a tertiary care center located in the largest population center (Portland) in the state of Maine. Serving as the hub of activities, this program will mentor cohorts of acute care researchers in significant clinical/translational areas of need while providing a foundation for these studies to impact communities and patients in all regions of our state. This COBRE is led by Douglas Sawyer MD, PhD, an established leader in clinical care services, mentorship, and translational research. The aims of this program are: 1) Provide the leadership, governance, and advisory network to establish a COBRE in Acute Care Research and Rural Disparities at Maine Medical Center; 2) Provide project and mentorship support to launch the careers of promising clinician-scientists within this scientific program, and help ensure their long-term scientific success as independent researchers; 3) Enhance the capabilities of Maine Medical Center's core facilities and research infrastructure to support human subject research of both our COBRE investigators and other institutional and external researchers, and to stimulate innovative research methodologies and new collaborations, and 4) Enhance our existing COBRE- and CTR-supported pilot project programs to focus on translational and clinical opportunities related to acute care and rural health disparities. In Phase I, we have initially selected 4 clinical/translational project leaders with clinical research areas of primary need. These include: Teresa May DO, a critical care physician-researcher developing a standardized statewide system of cardiac arrest post-resuscitation care, David Gagnon PharmD, a pharmacist-researcher testing the benefits of prophylactic antibiotics in cardiac arrest survivors, David Seder MD, a critical care physician-researcher expanding his clinical research program to include translational molecular signaling studies of inflammation in cardiac arrest, and Alexa Craig MD, a pediatric neurologist engaged in research utilizing telemedicine to improve survival and neurological outcomes for newborns born at risk for encephalopathy. These researchers will be supported by a robust mentorship and advisory network and a Community Engagement, Bioethics, and Outreach Core that will develop state-wide health professional and community partnerships in a learning healthcare system to enhance understanding of and increase inclusion in human subjects research.

急性护理研究可定义为对预防、治疗、康复或姑息治疗的调查需要采取具有时间敏感性的紧急干预行动。因此，急性护理包括多种医疗专科，包括重症监护服务、急诊和紧急护理、创伤和急症护理手术，以及神经重症监护在农村各州，需要改善急性护理和急性护理研究，迫切需要，因为医疗进步扩大了城乡之间的差距。这些这种差距在很大程度上是由于在获得经过专门培训的临床医生、资源和设施方面的不平衡，以及临床研究。我们建议建立一个新的跨部门生物医学研究卓越中心（COBRE）在缅因州医疗中心，一个三级保健中心位于最大的人口中心（波特兰），缅因州。作为活动的中心，该计划将指导急性护理研究人员在重要的临床/翻译领域的需要，同时为这些研究提供基础，以影响社区和病人在我们国家的所有地区。这个COBRE由道格拉斯索耶博士领导，在临床护理服务、导师制和转化研究方面确立了领先地位。这一方案的目标是：1）提供领导，治理和咨询网络，以建立急性护理COBRE 缅因州医疗中心的研究和农村差异; 2）提供项目和导师支持，在这个科学计划中有前途的临床科学家的职业生涯，并帮助确保他们的长期作为独立研究人员的科学成功; 3）提高缅因州医疗中心核心的能力设施和研究基础设施，以支持我们的COBRE研究人员和其他机构和外部研究人员，并激励创新的研究方法和新的合作，以及4）加强我们现有的COBRE和CTR支持的试点项目计划，重点是与急性护理和农村健康差距有关的转化和临床机会。在第一阶段，初步选择了4名具有主要需求的临床研究领域的临床/转化项目负责人。这些包括：Teresa May DO，一位重症监护医生研究员，他开发了一个标准化的全州系统，心脏骤停复苏后护理，大卫加格农药学博士，药剂师研究员测试的好处，心脏骤停幸存者的预防性抗生素，大卫塞德医学博士，重症监护医生研究员扩大他的临床研究计划，包括炎症的翻译分子信号研究，心脏骤停，和Alexa克雷格医学博士，儿科神经学家从事研究利用远程医疗，提高新生儿存活率和神经功能预后，出生时有脑病风险。这些研究人员将得到强大的指导和咨询网络以及社区参与，生物伦理学和外展核心，将发展全州范围内的卫生专业人员和社区伙伴关系，在学习医疗保健系统，以提高对人类受试者研究的理解和包容性。