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Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities

急性护理研究和农村差异生物医学卓越研究中心

基本信息

批准号：
10090065
负责人：
Douglas B Sawyer
金额：
$ 259.69万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-10 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10090065
关键词：
Acute Address Adult Antibiotic Prophylaxis Antibiotics Area Bioethics Caring Center for Translational Science Activities Centers of Research Excellence Childhood Clinical Clinical Research Collaborations Communities Consent Core Facility Critical Care Development Disadvantaged Doctor of Pharmacy Doctor of Philosophy Emergency Care Emergency Situation Emergency medical service Encephalopathies Ensure Event Foundations Funding Future Goals Health Professional Healthcare Systems Heart Arrest Human Subject Research Hypoxia Inflammation Infrastructure Injury Intervention Investigation Leadership Learning Longevity Maine Medical Medical center Mentors Mentorship Methods Molecular Neurological outcome Neurologist Newborn Infant Operative Surgical Procedures Outcome Patient-Focused Outcomes Patients Pharmacists Phase Physicians Pilot Projects Pneumonia Population Preventive Process Protocols documentation Rehabilitation therapy Research Research Infrastructure Research Institute Research Methodology Research Personnel Research Support Resources Resuscitation Risk Rural Rural Community Rural Health Rural Population Scientist Services Signal Transduction Site Standardization Survivors System Technology Telemedicine Testing Time Training Training Support Translational Research Travel United States National Institutes of Health Variant acute care base care delivery care systems career clinical care clinical infrastructure cohesion cohort community engagement community involvement community partnership design disparity reduction diversity and inclusion experience health care disparity health disparity immunoregulation improved improved outcome innovation medical specialties neonatal hypoxic-ischemic brain injury neonate neuroprotection novel novel therapeutics outreach palliative prevent programs prophylactic research study response resuscitative care rural area rural disparities rural health disparities rural patients rurality success survival outcome teleconsent tertiary care tool translational research program trauma care urban area urgent care

项目摘要

Acute care research can be defined as investigations into preventive, curative, rehabilitative, or palliative actions that depend on time-sensitive and urgent intervention. Thus, acute care encompasses multiple medical specialties, including critical care services, emergency and urgent care, trauma and acute care surgery, and neurocritical care. In rural states, the need for improvements in acute care and acute care research are pressing, as medical advances have increased the disparities between urban and rural areas. These disparities are due in large part to imbalances in access to specialty-trained clinicians, resources and facilities, as well as clinical research. We propose a new inter-departmental Center for Biomedical Research Excellence (COBRE) at Maine Medical Center, a tertiary care center located in the largest population center (Portland) in the state of Maine. Serving as the hub of activities, this program will mentor cohorts of acute care researchers in significant clinical/translational areas of need while providing a foundation for these studies to impact communities and patients in all regions of our state. This COBRE is led by Douglas Sawyer MD, PhD, an established leader in clinical care services, mentorship, and translational research. The aims of this program are: 1) Provide the leadership, governance, and advisory network to establish a COBRE in Acute Care Research and Rural Disparities at Maine Medical Center; 2) Provide project and mentorship support to launch the careers of promising clinician-scientists within this scientific program, and help ensure their long-term scientific success as independent researchers; 3) Enhance the capabilities of Maine Medical Center's core facilities and research infrastructure to support human subject research of both our COBRE investigators and other institutional and external researchers, and to stimulate innovative research methodologies and new collaborations, and 4) Enhance our existing COBRE- and CTR-supported pilot project programs to focus on translational and clinical opportunities related to acute care and rural health disparities. In Phase I, we have initially selected 4 clinical/translational project leaders with clinical research areas of primary need. These include: Teresa May DO, a critical care physician-researcher developing a standardized statewide system of cardiac arrest post-resuscitation care, David Gagnon PharmD, a pharmacist-researcher testing the benefits of prophylactic antibiotics in cardiac arrest survivors, David Seder MD, a critical care physician-researcher expanding his clinical research program to include translational molecular signaling studies of inflammation in cardiac arrest, and Alexa Craig MD, a pediatric neurologist engaged in research utilizing telemedicine to improve survival and neurological outcomes for newborns born at risk for encephalopathy. These researchers will be supported by a robust mentorship and advisory network and a Community Engagement, Bioethics, and Outreach Core that will develop state-wide health professional and community partnerships in a learning healthcare system to enhance understanding of and increase inclusion in human subjects research.

急性护理研究可以定义为对预防、治疗、康复或姑息的研究。依赖于时间敏感和紧急干预的行动。因此，急性护理包括多个医疗保健专科，包括危重护理服务、紧急和紧急护理、创伤和急性护理手术，以及神经危重护理。在农村州，急诊护理和急诊护理研究需要改进迫在眉睫的是，医疗进步扩大了城乡之间的差距。这些差异在很大程度上是由于在获得受过专门培训的临床医生、资源和设施方面的不平衡，以及临床研究。我们建议成立一个新的跨部门生物医学研究卓越中心位于缅因州最大的人口中心(波特兰)的三级护理中心(Cobre) 缅因州。作为活动的中心，该计划将指导一批急性护理研究人员在重要的临床/翻译需求领域，同时为这些研究提供影响的基础我们州所有地区的社区和病人。Cobre由道格拉斯·索耶博士、博士和在临床护理服务、指导和转化性研究方面居于领先地位。这个项目的目的是是：1)提供领导、治理和咨询网络，以建立急救中心缅因州医疗中心的研究和农村差距；2)提供项目和指导支持，以启动在这一科学计划中，有前途的临床医生和科学家的职业生涯，并帮助确保他们的长期作为独立研究人员取得科学成功；3)增强缅因州医疗中心的核心能力设施和研究基础设施，以支持我们Cobre研究人员和其他机构和外部研究人员，并鼓励创新的研究方法和新的协作，以及4)增强我们现有的由Cobre和CTR支持的试点项目计划，以专注于与急性护理和农村健康差距有关的转化和临床机会。在第一阶段，我们有最初选择了4名临床/翻译项目负责人，他们的临床研究领域是主要需要的。这些包括：特蕾莎·梅·多，一位重症监护医生兼研究员，正在开发全州范围内的标准化系统心脏骤停复苏后护理，David Gagnon PharmD，药剂师兼研究员，测试心脏骤停幸存者的预防性抗生素，David Seder医学博士，重症监护医生兼研究员扩大他的临床研究计划，将炎症的翻译分子信号研究包括在内和Alexa Craig MD，一位致力于利用远程医疗进行研究的儿科神经科医生改善有脑病风险的新生儿的存活率和神经预后。这些研究人员将得到强大的指导和咨询网络以及社区参与、生物伦理和外展核心，将在学习中发展全州卫生专业人员和社区伙伴关系医疗保健系统，以加强对人类受试者研究的理解和纳入。