Leadership Administrative Core

领导行政核心

• 批准号: 10349460
• 负责人: JILL M GOLDSTEIN
• 金额: $ 14.16万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10349460
• 关键词: Animal Model; Animals; Attenuated; Biological; Biological Models; Budgets; Cardiovascular Diseases; Centers of Research Excellence; Clinical; Clinical Investigator; Clinical Medicine; Clinical Research; Collaborations; Communities; Consultations; Country; Discipline; Disease; Early Intervention; Educational workshop; Elderly; Electronic Mail; Endocrinology; Evaluation; Expenditure; Fetal Development; Functional disorder; Funding; Future; Genetic; Goals; Heart Diseases; Hormones; Human; Immune; Immune response; Immunology; Infrastructure; Institution; Interdisciplinary Study; Knowledge; Leadership; Life; Locales; Major Depressive Disorder; Medical; Mental Depression; Metabolic Diseases; Methodology; Methods; Mission; Modeling; Monitor; Moods; Neurology; Neurosciences; Pathway interactions; Peripheral; Physiological; Policy Maker; Population; Psychiatry; Public Health; Publications; Radiology Specialty; Recurrence; Reporting; Resources; Risk; Schedule; Scientist; Series; Sex Differences; Site; Specialized Center; Stress; Technology; Telephone; Therapeutic; Thinking; Time; Training; Translating; Translational Research; United States National Institutes of Health; Woman; Work; base; brain circuitry; career; disability; disorder risk; high risk; meetings; middle age; mortality risk; neural circuit; neurovascular; next generation; novel; novel strategies; prenatal stress; sex; specific biomarkers; symposium; tool; translational study; web site

LAC SUMMARY The scientific mission of this SCORE is to identify stress-immune pathway abnormalities, beginning in fetal development, that have shared consequences for sex differences in brain circuitry regulating mood and lifelong recurrent MDD and dysregulation of hormone and immune responses to stress, and autonomic and neurovascular dysfunction in early midlife. We aim to facilitate transdisciplinary, translational collaboration among basic and clinical investigators to enhance our understanding of the impact of sex on MDD and central and peripheral autonomic function and translate this knowledge into sex-selective therapeutics. Further, we aim to serve as an interdisciplinary resource to train and disseminate findings about sex differences in MDD and autonomic dysregulation to the scientific and medical communities, policy makers, and the public. To accomplish our aims in three projects and three cores, we are proposing a series of interdisciplinary and translational studies from basic and clinical neuroscience and population-level perspectives, integrating scientists from different disciplines and institutions ranging from the lab bench to the clinical level. In the Resource Support Core (RSC), we are integrating and introducing novel state-of-the-art technologies, with some that will cross human and animal work. In the Career Enhancement Core (CEC), educating young scientists in new approaches and insuring that their future work will translate sex as a biologic variable into their (and others') thinking in clinical medicine. The Leadership Administrative Core (LAC) is essential in providing an infrastructure to monitor, integrate, and synergize ongoing activities. The specific aims of the LAC are to: Coordinate activities of the SCORE; Administer budgets, insuring financial responsibility and coordination across sites and activities; and Disseminate knowledge through online tools, organizing symposia and workshops and other avenues to connect the SCORE with the medical community, policy makers, NIH, and the public.

Lac摘要 这项评分的科学任务是识别应激免疫途径的异常，从胎儿开始。 发育，这对调节情绪和终生的大脑回路的性别差异有共同的影响 反复出现的MDD和激素调节失调以及对应激的免疫反应，以及自主神经和 中年早期的神经血管功能障碍。我们的目标是促进跨学科的翻译协作 在基础和临床研究人员中，以加强我们对性别对MDD和中央 和外周自主神经功能，并将这些知识转化为性别选择疗法。此外，我们 旨在作为一个跨学科的资源，培训和传播有关MDD性别差异的研究结果 以及对科学和医学界、政策制定者和公众的自主失调。 为了实现我们在三个项目和三个核心方面的目标，我们提出了一系列跨学科和 从基础和临床神经科学和人口水平角度进行的翻译研究，整合 来自不同学科和机构的科学家，从实验室到临床水平。在 资源支持核心(RSC)，我们正在集成和引入最先进的新技术， 有些将跨越人类和动物的工作。在职业提升核心(CEC)中，教育年轻人 科学家们正在寻找新的方法，并确保他们未来的工作将把性作为一个生物变量转化为 他们(和其他人)在临床医学上的想法。领导力管理核心(LAC)在 提供监控、集成和协同正在进行的活动的基础设施。拉丁美洲和加勒比地区的具体目标 是：协调分数的活动；管理预算，确保财务责任和 协调各站点和活动；通过在线工具传播知识，组织研讨会 以及研讨会和其他途径，将该分数与医学界、政策制定者、NIH、 以及公众。