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Leadership Administrative Core

领导行政核心

基本信息

批准号：
10349460
负责人：
JILL M GOLDSTEIN
金额：
$ 14.16万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10349460
关键词：
Animal Model Animals Attenuated Biological Biological Models Budgets Cardiovascular Diseases Centers of Research Excellence Clinical Clinical Investigator Clinical Medicine Clinical Research Collaborations Communities Consultations Country Discipline Disease Early Intervention Educational workshop Elderly Electronic Mail Endocrinology Evaluation Expenditure Fetal Development Functional disorder Funding Future Genetic Goals Heart Diseases Hormones Human Immune Immune response Immunology Infrastructure Institution Interdisciplinary Study Knowledge Leadership Life Locales Major Depressive Disorder Medical Mental Depression Metabolic Diseases Methodology Methods Mission Modeling Monitor Moods Neurology Neurosciences Pathway interactions Peripheral Physiological Policy Maker Population Psychiatry Public Health Publications Radiology Specialty Recurrence Reporting Resources Risk Schedule Scientist Series Sex Differences Site Specialized Center Stress Technology Telephone Therapeutic Thinking Time Training Translating Translational Research United States National Institutes of Health Woman Work base brain circuitry career disability disorder risk high risk meetings middle age mortality risk neural circuit neurovascular next generation novel novel strategies prenatal stress sex specific biomarkers symposium tool translational study web site

项目摘要

LAC SUMMARY The scientific mission of this SCORE is to identify stress-immune pathway abnormalities, beginning in fetal development, that have shared consequences for sex differences in brain circuitry regulating mood and lifelong recurrent MDD and dysregulation of hormone and immune responses to stress, and autonomic and neurovascular dysfunction in early midlife. We aim to facilitate transdisciplinary, translational collaboration among basic and clinical investigators to enhance our understanding of the impact of sex on MDD and central and peripheral autonomic function and translate this knowledge into sex-selective therapeutics. Further, we aim to serve as an interdisciplinary resource to train and disseminate findings about sex differences in MDD and autonomic dysregulation to the scientific and medical communities, policy makers, and the public. To accomplish our aims in three projects and three cores, we are proposing a series of interdisciplinary and translational studies from basic and clinical neuroscience and population-level perspectives, integrating scientists from different disciplines and institutions ranging from the lab bench to the clinical level. In the Resource Support Core (RSC), we are integrating and introducing novel state-of-the-art technologies, with some that will cross human and animal work. In the Career Enhancement Core (CEC), educating young scientists in new approaches and insuring that their future work will translate sex as a biologic variable into their (and others') thinking in clinical medicine. The Leadership Administrative Core (LAC) is essential in providing an infrastructure to monitor, integrate, and synergize ongoing activities. The specific aims of the LAC are to: Coordinate activities of the SCORE; Administer budgets, insuring financial responsibility and coordination across sites and activities; and Disseminate knowledge through online tools, organizing symposia and workshops and other avenues to connect the SCORE with the medical community, policy makers, NIH, and the public.

LAC总结