Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation

重度抑郁症的性别差异:产前压力免疫和自主神经失调的影响

基本信息

  • 批准号:
    10747460
  • 负责人:
  • 金额:
    $ 6.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-02-01 至 2024-12-31
  • 项目状态:
    已结题

项目摘要

OVERALL SUMMARY. Major depressive disorder (MDD) topped heart disease as the number one cause of disability worldwide, and women have twice the risk of men. MDD is associated with abnormalities in the stress response circuitry, areas that are among the most sexually dimorphic in the brain. These areas are dense in sex steroid and glucocorticoid receptors coupled with cytokine receptors. Further, activity in these areas has been associated with cortisol response, autonomic dysfunction, and immune responses, which we showed differed by sex. This is important since autonomic dysregulation is significantly associated with cardiovascular disease. In fact, women are at twice the risk for the co-occurrence of MDD, autonomic dysregulation and heart disease, leading to a 3-5-fold risk of death in women from heart disease, often with unrecognized and untreated MDD. Thus, understanding early biomarkers for sex differences in MDD and autonomic dysregulation will provide knowledge for early intervention, attenuating later life disability, in particular for women who are at higher risk. The scientific mission of this SCORE is to identify stress-immune pathway abnormalities, beginning in fetal development, that have shared consequences for sex differences in brain circuitry regulating mood and lifelong recurrent MDD and dysregulation of hormone and immune responses to stress, and autonomic and neurovascular dysfunction in early midlife. We aim to facilitate transdisciplinary, translational collaboration among basic and clinical investigators to enhance our understanding of the impact of sex on MDD and central and peripheral autonomic function and provide the groundwork for translating this knowledge into sex-selective therapeutics. Further, we aim to serve as an interdisciplinary resource to train and disseminate findings about sex differences in MDD and autonomic dysregulation to the scientific and medical communities, policy makers, and the public. To accomplish this, three integrated studies are proposed: 1) a clinical population neuroscience study relating prenatal risk biomarkers to sex differences in brain circuitry and physiologic deficits in response to stress in MDD in early midlife; 2) clinical study using direct transcutaneous neuromodulatory stimulation of the vagus nerve, auricular branch (or taVNS) to target the circuitry associated with stress-immune function and map its neuroanatomic, physiologic and clinical effects in MDD by sex, in the same subjects as in project 1; and 3) rodent model studies that will map out the central mechanistic pathways involved in projects 1 and 2. In addition, three cores will contribute to the success of this SCORE: 1) Leadership Administration Core to administer and oversee the administrative integration of the studies and cores; 2) Resources Core to provide shared technical expertise across studies; and 3) Career Enhancement Core, to supplement the training of junior faculty and others on the topic of our SCORE, and become pedagogical ambassadors to the scientific, medical and public communities about sex differences in depression and comorbidities with general medicine, a topic with global public health implications.
整体总结。重度抑郁症(MDD)超过心脏病,成为导致死亡的头号原因

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

JILL M GOLDSTEIN其他文献

JILL M GOLDSTEIN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('JILL M GOLDSTEIN', 18)}}的其他基金

Impact of sex differences in immune function on shared risk for cardiometabolic disorder & Alzheimer's disease
免疫功能性别差异对心脏代谢疾病共同风险的影响
  • 批准号:
    10300822
  • 财政年份:
    2021
  • 资助金额:
    $ 6.22万
  • 项目类别:
Impact of Sex on Prenatal Stress-Immune Programming of Depression and Autonomic Dysregulation
性别对抑郁症和自主神经失调的产前应激免疫编程的影响
  • 批准号:
    10349463
  • 财政年份:
    2020
  • 资助金额:
    $ 6.22万
  • 项目类别:
Leadership Administrative Core
领导行政核心
  • 批准号:
    10089490
  • 财政年份:
    2020
  • 资助金额:
    $ 6.22万
  • 项目类别:
Leadership Administrative Core
领导行政核心
  • 批准号:
    10540780
  • 财政年份:
    2020
  • 资助金额:
    $ 6.22万
  • 项目类别:
Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation
重度抑郁症的性别差异:产前压力免疫和自主神经失调的影响
  • 批准号:
    10349458
  • 财政年份:
    2020
  • 资助金额:
    $ 6.22万
  • 项目类别:
Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation
重度抑郁症的性别差异:产前压力免疫和自主神经失调的影响
  • 批准号:
    10089485
  • 财政年份:
    2020
  • 资助金额:
    $ 6.22万
  • 项目类别:
Impact of Sex on Prenatal Stress-Immune Programming of Depression and Autonomic Dysregulation
性别对抑郁症和自主神经失调的产前应激免疫编程的影响
  • 批准号:
    10089493
  • 财政年份:
    2020
  • 资助金额:
    $ 6.22万
  • 项目类别:
Building a Translational Workforce Innovation Network (TWIN)
建立转化型劳动力创新网络(TWIN)
  • 批准号:
    10864217
  • 财政年份:
    2020
  • 资助金额:
    $ 6.22万
  • 项目类别:
Leadership Administrative Core
领导行政核心
  • 批准号:
    10349460
  • 财政年份:
    2020
  • 资助金额:
    $ 6.22万
  • 项目类别:
Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation
重度抑郁症的性别差异:产前压力免疫和自主神经失调的影响
  • 批准号:
    10527864
  • 财政年份:
    2020
  • 资助金额:
    $ 6.22万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了