权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Leadership Administrative Core

领导行政核心

基本信息

批准号：
10540780
负责人：
JILL M GOLDSTEIN
金额：
$ 14.51万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10540780
关键词：
Animal Model Animals Biological Biological Models Budgets Cardiovascular Diseases Centers of Research Excellence Clinical Clinical Investigator Clinical Medicine Clinical Research Collaborations Communities Consultations Country Discipline Disease Early Intervention Educational workshop Elderly Electronic Mail Endocrinology Evaluation Expenditure Fetal Development Functional disorder Funding Future Genetic Goals Heart Diseases Hormones Human Immune Immune response Immunology Infrastructure Institution Interdisciplinary Study Knowledge Leadership Life Locales Major Depressive Disorder Medical Mental Depression Metabolic Diseases Methodology Methods Mission Modeling Monitor Moods Neurology Neurosciences Pathway interactions Peripheral Physiological Policy Maker Population Psychiatry Public Health Publications Radiology Specialty Recurrence Reporting Resources Risk Schedule Scientist Series Sex Differences Site Specialized Center Stress Technology Telephone Therapeutic Thinking Time Training Translating Translational Research United States National Institutes of Health Woman Work brain circuitry career disability disorder risk high risk meetings middle age mortality risk neural circuit neurovascular next generation novel novel strategies prenatal stress sex specific biomarkers symposium synergism tool translational study web site

项目摘要

LAC SUMMARY The scientific mission of this SCORE is to identify stress-immune pathway abnormalities, beginning in fetal development, that have shared consequences for sex differences in brain circuitry regulating mood and lifelong recurrent MDD and dysregulation of hormone and immune responses to stress, and autonomic and neurovascular dysfunction in early midlife. We aim to facilitate transdisciplinary, translational collaboration among basic and clinical investigators to enhance our understanding of the impact of sex on MDD and central and peripheral autonomic function and translate this knowledge into sex-selective therapeutics. Further, we aim to serve as an interdisciplinary resource to train and disseminate findings about sex differences in MDD and autonomic dysregulation to the scientific and medical communities, policy makers, and the public. To accomplish our aims in three projects and three cores, we are proposing a series of interdisciplinary and translational studies from basic and clinical neuroscience and population-level perspectives, integrating scientists from different disciplines and institutions ranging from the lab bench to the clinical level. In the Resource Support Core (RSC), we are integrating and introducing novel state-of-the-art technologies, with some that will cross human and animal work. In the Career Enhancement Core (CEC), educating young scientists in new approaches and insuring that their future work will translate sex as a biologic variable into their (and others') thinking in clinical medicine. The Leadership Administrative Core (LAC) is essential in providing an infrastructure to monitor, integrate, and synergize ongoing activities. The specific aims of the LAC are to: Coordinate activities of the SCORE; Administer budgets, insuring financial responsibility and coordination across sites and activities; and Disseminate knowledge through online tools, organizing symposia and workshops and other avenues to connect the SCORE with the medical community, policy makers, NIH, and the public.

LAC摘要该SCORE的科学使命是识别应激免疫通路异常，从胎儿开始发展，这对调节情绪的大脑回路的性别差异和终身的复发性MDD和对应激的激素和免疫反应失调，以及自主神经和神经血管功能障碍。我们的目标是促进跨学科，翻译合作在基础和临床研究者中，以提高我们对性别对MDD和中枢神经系统的影响的理解。和外周自主神经功能，并将这些知识转化为性别选择性治疗。我们还旨在作为一个跨学科的资源，培训和传播有关MDD性别差异的发现以及对科学和医学界、政策制定者和公众的自主调节失调。为了实现三个项目和三个核心的目标，我们提出了一系列跨学科和从基础和临床神经科学和人群水平的角度进行转化研究，来自不同学科和机构的科学家，从实验室工作台到临床水平。在资源支持核心（RSC），我们正在整合和引入新的最先进的技术，有些将跨越人类和动物的工作。在职业提升核心（CEC）中，科学家们正在研究新的方法，并确保他们未来的工作将把性别作为一个生物变量，他们（和其他人）在临床医学上的想法。领导行政核心（LAC）是必不可少的，提供基础设施以监控、整合和协同正在进行的活动。拉加经委会的具体目标是：协调SCORE的活动;管理预算，确保财务责任，通过在线工具传播知识，组织研讨会，研讨会和其他途径，以连接SCORE与医学界，政策制定者，国家卫生研究院，及公众