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Building a Translational Workforce Innovation Network (TWIN)

建立转化型劳动力创新网络（TWIN）

基本信息

批准号：
10864217
负责人：
JILL M GOLDSTEIN
金额：
$ 49.21万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10864217
关键词：
Academia Address Administrative Supplement Arizona Attenuated Automobile Driving Back Basic Science Biological Models Biomedical Engineering Brain Cardiac Cardiometabolic Disease Cardiovascular Diseases Career Mobility Clinical Sciences Collaborations Colorado Communities Country Creativeness Data Data Science Development Devices Disease Early Intervention Educational Curriculum Elderly Engineering Entrepreneurship Event Family Fetal Development Functional disorder Funding General Hospitals Generations Health Healthcare Industry Heart Heart Diseases Immune Individual Industry Infrastructure Institution Intellectual Property Intelligence Investigation Knowledge Leadership Learning Massachusetts Medical Medicine Mental Depression Mental Health Mentors Metabolic Mission Neurosciences Pathway interactions Play Pregnancy Complications Privatization Problem Solving Process Psychiatry Publications Resources Risk Role Science Sex Differences Site System Technology Technology Transfer Training Training Programs Translating Translations Underrepresented Populations Universities Woman Women&apos s Health Work career comorbidity design diagnostic tool disability experience fetal fetal programming health care service utilization improved in utero industry partner innovation interest medical schools meetings men mortality risk multidisciplinary neuroregulation neurovascular next generation novel novel diagnostics offspring physical conditioning precision medicine product development programs prototype sex skills technology development tool

项目摘要

There are a growing number of efforts across the country to create an educated workforce for the biomedical sciences, engineering, and technology, and related industries. There is a significant need to incorporate the differential needs of women and men into the world of entrepreneurship and product development to enhance scientific discovery and creative solutions for medical needs. In this Administrative Supplement, we begin to address this need by applying it to our SCORE scientific mission of identifying immune abnormalities, with fetal origins, that have consequences for sex differences in depression and comorbidity with autonomic dysregulation and cardio- and neuro-vascular dysfunction in later life. Women are at twice the risk for the co- occurrence of this, leading to an increased risk of death in women. We will elevate the scientific mission of our SCORE and its Career Enhancement Core (CEC) by formulating a pipeline program that infuses consideration of sex differences that are shared across the brain and heart to create a SCORE Translational Workforce Innovation Network (TWIN) building academic-industry (public-private) partnerships. TWIN will be a collaboration among our SCORE institutions and the Innovation Center on Sex Differences in Medicine (ICON- X) at Massachusetts General Hospital (MGH-primary site of the SCORE). The SCORE TWIN will: 1) Create new knowledge steeped in sex differences in brain, heart and gut that incorporates critical skills required for biomedical innovation management; 2) Enable its transfer into products, processes, and systems to improve mental and physical health; 3) Improve workforce innovation management; 4) Increase biomedical workforce diversity, in particular women in STEM leadership; and 5) Create a sustainable infrastructure that can be used as a prototype for other training programs. The aims are to: Extend CEC programs & develop curricula to create academic-industry partnerships where trainees will learn to identify and protect intellectual property and translate knowledge of sex differences in the brain and heart into diagnostic tools and therapies; Create multi- level mentoring groups to establish a next generation community of academic women and men and cross- sector mentoring/coaching teams who will encourage open exchange of ideas, career advancement, and problem solving to address development of sex-selective diagnostic tools and therapies for depression and comorbid cardiometabolic diseases; Provide seed funding to supplement and extend basic and clinical science studies to infuse industry knowledge to make the development process more efficient; and Disseminate findings to publicize our model system enabling knowledge transfer from academia to industry and back to academia that incorporates the impact of sex. Our trainees will be ambassadors for creating a more informed, translationally focused workforce among other SCOREs and training programs. This training will take advantage of greater participation of women and under-represented populations in STEM to enhance discovery and product development for mental health.

在全国范围内，为培养受过良好教育的生物医学工作者，正在作出越来越多的努力