Building a Translational Workforce Innovation Network (TWIN)

建立转化型劳动力创新网络（TWIN）

• 批准号: 10864217
• 负责人: JILL M GOLDSTEIN
• 金额: $ 49.21万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10864217
• 关键词: Academia; Address; Administrative Supplement; Arizona; Attenuated; Automobile Driving; Back; Basic Science; Biological Models; Biomedical Engineering; Brain; Cardiac; Cardiometabolic Disease; Cardiovascular Diseases; Career Mobility; Clinical Sciences; Collaborations; Colorado; Communities; Country; Creativeness; Data; Data Science; Development; Devices; Disease; Early Intervention; Educational Curriculum; Elderly; Engineering; Entrepreneurship; Event; Family; Fetal Development; Functional disorder; Funding; General Hospitals; Generations; Health; Healthcare Industry; Heart; Heart Diseases; Immune; Individual; Industry; Infrastructure; Institution; Intellectual Property; Intelligence; Investigation; Knowledge; Leadership; Learning; Massachusetts; Medical; Medicine; Mental Depression; Mental Health; Mentors; Metabolic; Mission; Neurosciences; Pathway interactions; Play; Pregnancy Complications; Privatization; Problem Solving; Process; Psychiatry; Publications; Resources; Risk; Role; Science; Sex Differences; Site; System; Technology; Technology Transfer; Training; Training Programs; Translating; Translations; Underrepresented Populations; Universities; Woman; Women' s Health; Work; career; comorbidity; design; diagnostic tool; disability; experience; fetal; fetal programming; health care service utilization; improved; in utero; industry partner; innovation; interest; medical schools; meetings; men; mortality risk; multidisciplinary; neuroregulation; neurovascular; next generation; novel; novel diagnostics; offspring; physical conditioning; precision medicine; product development; programs; prototype; sex; skills; technology development; tool

There are a growing number of efforts across the country to create an educated workforce for the biomedical sciences, engineering, and technology, and related industries. There is a significant need to incorporate the differential needs of women and men into the world of entrepreneurship and product development to enhance scientific discovery and creative solutions for medical needs. In this Administrative Supplement, we begin to address this need by applying it to our SCORE scientific mission of identifying immune abnormalities, with fetal origins, that have consequences for sex differences in depression and comorbidity with autonomic dysregulation and cardio- and neuro-vascular dysfunction in later life. Women are at twice the risk for the co- occurrence of this, leading to an increased risk of death in women. We will elevate the scientific mission of our SCORE and its Career Enhancement Core (CEC) by formulating a pipeline program that infuses consideration of sex differences that are shared across the brain and heart to create a SCORE Translational Workforce Innovation Network (TWIN) building academic-industry (public-private) partnerships. TWIN will be a collaboration among our SCORE institutions and the Innovation Center on Sex Differences in Medicine (ICON- X) at Massachusetts General Hospital (MGH-primary site of the SCORE). The SCORE TWIN will: 1) Create new knowledge steeped in sex differences in brain, heart and gut that incorporates critical skills required for biomedical innovation management; 2) Enable its transfer into products, processes, and systems to improve mental and physical health; 3) Improve workforce innovation management; 4) Increase biomedical workforce diversity, in particular women in STEM leadership; and 5) Create a sustainable infrastructure that can be used as a prototype for other training programs. The aims are to: Extend CEC programs & develop curricula to create academic-industry partnerships where trainees will learn to identify and protect intellectual property and translate knowledge of sex differences in the brain and heart into diagnostic tools and therapies; Create multi- level mentoring groups to establish a next generation community of academic women and men and cross- sector mentoring/coaching teams who will encourage open exchange of ideas, career advancement, and problem solving to address development of sex-selective diagnostic tools and therapies for depression and comorbid cardiometabolic diseases; Provide seed funding to supplement and extend basic and clinical science studies to infuse industry knowledge to make the development process more efficient; and Disseminate findings to publicize our model system enabling knowledge transfer from academia to industry and back to academia that incorporates the impact of sex. Our trainees will be ambassadors for creating a more informed, translationally focused workforce among other SCOREs and training programs. This training will take advantage of greater participation of women and under-represented populations in STEM to enhance discovery and product development for mental health.

全国各地正在努力为生物医学创造一支受过教育的劳动力队伍 科学、工程和技术以及相关产业。很有必要将 男女进入创业和产品开发领域的不同需求 针对医疗需求的科学发现和创造性解决方案。在这份行政副刊中，我们开始 通过将其应用于我们识别免疫异常的Score科学任务来解决这一需求， 起源，对抑郁症的性别差异和与自主神经的共病有影响 在晚年生活中的调节失调和心脏和神经血管功能障碍。女性的风险是女性的两倍- 这种情况的发生，导致妇女死亡风险增加。我们将提升我们的科学使命 SCORE及其职业提升核心(CEC)，通过制定注入考虑的管道计划 大脑和心脏共有的性别差异创造了一支翻译员工队伍 创新网络(孪生)建立学术-产业(公共-私人)伙伴关系。双胞胎将成为一名 我们的评分机构和医学性别差异创新中心之间的合作(ICON- X)在马萨诸塞州综合医院(MGH--得分的主要地点)。比分双胞胎将：1)创造 新知识渗透于大脑、心脏和肠道的性别差异，包含了 生物医学创新管理；2)使其转化为产品、过程和系统进行改进 身心健康；3)改进劳动力创新管理；4)增加生物医学劳动力 多样性，特别是STEM领导层中的妇女；以及5)创建可利用的可持续基础设施 作为其他培训项目的原型。其目标是：扩展CEC课程和开发课程，以 建立学术-行业合作伙伴关系，学员将学习识别和保护知识产权，并 将大脑和心脏的性别差异知识转化为诊断工具和治疗方法；创建多个 层面的指导小组，建立下一代学术女性和男性社区，并交叉 部门指导/教练团队，将鼓励开放的思想交流、职业发展和 解决问题以解决抑郁症和抑郁症性别选择性诊断工具和疗法的开发问题 共患心脏代谢性疾病；提供种子资金补充和推广基础和临床 科学研究以灌输行业知识，使开发过程更有效率；以及 发布研究结果，宣传我们的模式系统，使知识从学术界转移到产业界 回到并入性影响的学术界。我们的实习生将成为创建一个 在其他分数和培训计划中，更有见多识广、专注于翻译的劳动力。这次培训 将利用STEM中更多的妇女和代表性不足的人口的参与，以加强 精神健康的发现和产品开发。