Building a Translational Workforce Innovation Network (TWIN)

建立转化型劳动力创新网络（TWIN）

• 批准号: 10864217
• 负责人: JILL M GOLDSTEIN
• 金额: $ 49.21万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10864217
• 关键词: Academia; Address; Administrative Supplement; Arizona; Attenuated; Automobile Driving; Back; Basic Science; Biological Models; Biomedical Engineering; Brain; Cardiac; Cardiometabolic Disease; Cardiovascular Diseases; Career Mobility; Clinical Sciences; Collaborations; Colorado; Communities; Country; Creativeness; Data; Data Science; Development; Devices; Disease; Early Intervention; Educational Curriculum; Elderly; Engineering; Entrepreneurship; Event; Family; Fetal Development; Functional disorder; Funding; General Hospitals; Generations; Health; Healthcare Industry; Heart; Heart Diseases; Immune; Individual; Industry; Infrastructure; Institution; Intellectual Property; Intelligence; Investigation; Knowledge; Leadership; Learning; Massachusetts; Medical; Medicine; Mental Depression; Mental Health; Mentors; Metabolic; Mission; Neurosciences; Pathway interactions; Play; Pregnancy Complications; Privatization; Problem Solving; Process; Psychiatry; Publications; Resources; Risk; Role; Science; Sex Differences; Site; System; Technology; Technology Transfer; Training; Training Programs; Translating; Translations; Underrepresented Populations; Universities; Woman; Women' s Health; Work; career; comorbidity; design; diagnostic tool; disability; experience; fetal; fetal programming; health care service utilization; improved; in utero; industry partner; innovation; interest; medical schools; meetings; men; mortality risk; multidisciplinary; neuroregulation; neurovascular; next generation; novel; novel diagnostics; offspring; physical conditioning; precision medicine; product development; programs; prototype; sex; skills; technology development; tool

There are a growing number of efforts across the country to create an educated workforce for the biomedical sciences, engineering, and technology, and related industries. There is a significant need to incorporate the differential needs of women and men into the world of entrepreneurship and product development to enhance scientific discovery and creative solutions for medical needs. In this Administrative Supplement, we begin to address this need by applying it to our SCORE scientific mission of identifying immune abnormalities, with fetal origins, that have consequences for sex differences in depression and comorbidity with autonomic dysregulation and cardio- and neuro-vascular dysfunction in later life. Women are at twice the risk for the co- occurrence of this, leading to an increased risk of death in women. We will elevate the scientific mission of our SCORE and its Career Enhancement Core (CEC) by formulating a pipeline program that infuses consideration of sex differences that are shared across the brain and heart to create a SCORE Translational Workforce Innovation Network (TWIN) building academic-industry (public-private) partnerships. TWIN will be a collaboration among our SCORE institutions and the Innovation Center on Sex Differences in Medicine (ICON- X) at Massachusetts General Hospital (MGH-primary site of the SCORE). The SCORE TWIN will: 1) Create new knowledge steeped in sex differences in brain, heart and gut that incorporates critical skills required for biomedical innovation management; 2) Enable its transfer into products, processes, and systems to improve mental and physical health; 3) Improve workforce innovation management; 4) Increase biomedical workforce diversity, in particular women in STEM leadership; and 5) Create a sustainable infrastructure that can be used as a prototype for other training programs. The aims are to: Extend CEC programs & develop curricula to create academic-industry partnerships where trainees will learn to identify and protect intellectual property and translate knowledge of sex differences in the brain and heart into diagnostic tools and therapies; Create multi- level mentoring groups to establish a next generation community of academic women and men and cross- sector mentoring/coaching teams who will encourage open exchange of ideas, career advancement, and problem solving to address development of sex-selective diagnostic tools and therapies for depression and comorbid cardiometabolic diseases; Provide seed funding to supplement and extend basic and clinical science studies to infuse industry knowledge to make the development process more efficient; and Disseminate findings to publicize our model system enabling knowledge transfer from academia to industry and back to academia that incorporates the impact of sex. Our trainees will be ambassadors for creating a more informed, translationally focused workforce among other SCOREs and training programs. This training will take advantage of greater participation of women and under-represented populations in STEM to enhance discovery and product development for mental health.

全国越来越多的努力为生物医学创造受过教育的劳动力 科学，工程和技术以及相关行业。有很大的需求纳入 男女的不同需求进入企业家精神和产品开发的世界，以增强 科学发现和医疗需求的创造性解决方案。在这种行政补充中，我们开始 通过将其应用于我们的得分科学使命，以识别免疫异常，并通过胎儿来解决这种需求 起源，这会影响抑郁症和合并症的性别差异 后来生活的功能障碍以及心脏和神经血管功能障碍。妇女的共同风险是 发生这种情况，导致女性死亡风险增加。我们将提升我们的科学任务 得分及其职业增强核心（CEC）通过制定注入考虑的管道计划 在整个大脑和心脏上共享的性别差异以创造分数转化劳动力 创新网络（Twin）建立学术行业（公私）伙伴关系。双胞胎将是一个 分数机构与医学性别差异的创新中心之间的合作（Icon- x）在马萨诸塞州综合医院（分数的MGH主要部位）。得分双胞胎将：1）创建 在大脑，心脏和肠道上融合了所需的关键技能的新知识中的新知识 生物医学创新管理； 2）将其转移到产品，流程和系统中以改进 身心健康； 3）改善劳动力创新管理； 4）增加生物医学劳动力 多样性，尤其是在STEM领导中的女性； 5）创建可以使用的可持续基础设施 作为其他培训计划的原型。目的是：扩展CEC计划并开发课程 建立学术行业伙伴关系，学员将学会识别和保护知识产权，并 将大脑和心脏性别差异的知识转化为诊断工具和疗法；创建多 级别的指导小组建立一个由学术男女组成的下一代社区，并交叉 部门指导/教练团队将鼓励开放交流思想，职业发展和 解决问题的问题，以解决性选择性诊断工具和抑郁症疗法的开发和 合并性心脏代谢性疾病；提供种子资金以补充和扩展基本和临床 科学研究以注入行业知识，以提高发展过程的效率；和 传播发现以宣传我们的模型系统，使知识从学术界转移到行业 然后回到纳入性影响的学术界。我们的学员将成为创建一个的大使 在其他分数和培训计划中，更有知情的，以翻译为重点的劳动力。这个培训 将利用妇女的更多参与和代表性不足的人群来增强 心理健康的发现和产品开发。