Does getting older signal improved mood repair for people with early-onset mood disorder histories? A longitudinal study of outcomes and mechanisms across middle age

对于有早发性情绪障碍史的人来说，变老是否意味着情绪修复得到改善？

• 批准号: 10361803
• 负责人: MARIA KOVACS
• 金额: $ 16.38万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10361803
• 关键词: Address; Administrative Supplement; Adult; Affect; Affective; Age; Aging; Area; Attention; Attenuated; Autonomic nervous system; Behavior; COVID-19; Chronic; Cognitive; Costs and Benefits; Databases; Decision Making; Depressed mood; Depressive disorder; Diagnosis; Distress; Economics; Emotional; Enrollment; Female; Goals; Individual; Individual Differences; Intervention; Laboratories; Life; Life Cycle Stages; Light; Link; Literature; Longitudinal Studies; Measures; Mental Depression; Mental Health; Modeling; Mood Disorders; Moods; Nervous System Physiology; Performance; Peripheral; Personality; Persons; Physiological; Predictive Value; Prevention; Procedures; Process; Psychopathology; Public Health; Recording of previous events; Regulation; Reporting; Resources; Rewards; Risk; Role; Sampling; Signal Transduction; Sympathetic Nervous System; Testing; Time; Use Effectiveness; Wages; Well in self; Woman; Work; age effect; age group; age related; aged; base; computational neuroscience; contextual factors; cost; depressive symptoms; discount; discounting; dysphoria; early onset; emotion regulation; human old age (65+); improved; information processing; men; middle age; negative affect; normal aging; novel; psychosocial; recruit; repaired; research study; response; sex; skills; success; trait; trend; young adult

Project Summary We are requesting an administrative supplement to make up for the loss of subject enrollment into the study during more than six months of state-mandated closure of our lab due to Covid-19 (while project staff continued to receive salaries). We need to finish recruitment of the proposed sample in order to fulfill the aims of the study and have the statistical power to test key hypotheses. The goals of this study remain as originally proposed. We were to build on a unique sample of Ss, heterogeneous with respect to risk of depressive disorder, who (in prior research studies) repeatedly reported during ages 18-35+ on their emotional well-being and how they attenuate sadness/distress (mood repair); their autonomic nervous system (ANS) functioning associated with affect processing was also assessed via peripheral measures. We propose to re-assess n=225 with histories of diagnosed depression and n=200 with no histories of depression once more, and thus extend the data base up to age 59 years, covering middle-age. We will identify latent trajectories of trait mood repair from ages 18 to 59 years and determine its correlates and the effects of personality, treatment exposure and ANS physiologic functioning on class membership; will examine the ability to repair mood in the laboratory; we will use a novel experimental procedure (the Cognitive Effort Discounting Paradigm or COG-ED), which quantifies the subjective cost of cognitive effort (involved in cost-benefit computations to perform a task), to examine the impact of affective load on effort-based decision making. We will test several clearly articulated hypotheses about : i) the effects of depressive illness history and sex on positive maturational effects in mood repair with age, ii) the predictive/moderating values of personality and treatment exposure on age-related mood repair changes, iii) the relations of latent-class mood repair trajectories to sex and shifts in ANS functioning over time; iv) the predictive value of latent-class mood repair trajectories for mood repair success in the laboratory; v) ever-depressed and never-depressed group-related differences on the COG-ED, and vi) the relations of COG-ED performance to mood repair trajectory membership and lab-based mood repair performance via attention refocusing. Our study will fill several gaps in the literature on emotion regulation and aging and represents the first step to assess the extent to which a neuro-economic approach to decision making reflects a mechanism that may explain mood repair choices.

项目摘要 我们正在申请行政补充，以弥补受试者入组研究的损失 在国家强制关闭我们实验室的六个多月期间，由于Covid-19（而项目工作人员 继续领取工资）。我们需要完成拟议样本的招募，以实现目标 并具有检验关键假设的统计能力。本研究的目标与最初相同 提出了我们将建立在一个独特的S样本上，在抑郁风险方面是异质的。 障碍，谁（在以前的研究）反复报告，在18-35岁以上的情绪福祉 以及他们如何减轻悲伤/痛苦（情绪修复）;他们的自主神经系统（ANS）功能 与情感处理相关的影响也通过周边措施进行了评估。我们建议重新评估n=225 有诊断抑郁症史的患者和没有抑郁症史的患者， 该数据库年龄最高可达59岁，覆盖中年人。我们将识别特质情绪修复的潜在轨迹 从18岁到59岁，并确定其相关性和个性，治疗暴露和 ANS生理功能对班级成员资格的影响;将在实验室检查修复情绪的能力;我们 将使用一种新的实验程序（认知努力折扣范式或COG-ED）， 量化认知努力的主观成本（涉及执行任务的成本效益计算）， 研究情感负荷对基于努力的决策的影响。我们将测试几个清晰表达的 假设：i）抑郁症病史和性别对情绪的积极成熟效应的影响 随着年龄的增长，ii）人格和治疗暴露对年龄相关性的预测/调节值 情绪修复的变化，iii）潜在类情绪修复轨迹与性别和ANS变化的关系 随着时间的推移发挥作用; iv）潜在类情绪修复轨迹对情绪修复成功的预测价值 在实验室中; v）在COG-ED上，曾经抑郁和从未抑郁的组相关差异，以及vi） COG-ED表现与情绪修复轨迹隶属度和实验室情绪修复的关系 通过重新集中注意力来表现。我们的研究将填补情绪调节文献中的几个空白， 这是评估神经经济学决策方法在多大程度上 制造反映了一种可能解释情绪修复选择的机制。