Does getting older signal improved mood repair for people with early-onset mood disorder histories? A longitudinal study of outcomes and mechanisms across middle age

项目摘要 我们要求一项行政补充，以弥补研究中学科注册的损失 在国家要求我们的实验室因新冠肺炎关闭的六个多月期间(同时项目人员 继续领取薪金)。我们需要完成建议样本的招聘，才能实现目标 并具有检验关键假设的统计能力。这项研究的目标一如既往。 建议。我们将建立一个独特的SS样本，关于抑郁的风险是不同的 精神障碍，他们(在先前的研究中)在18-35岁期间反复报告他们的情绪健康状况 以及他们如何减轻悲伤/痛苦(情绪修复)；他们的自主神经系统(ANS)功能 与情感处理相关的研究也通过外围测量进行了评估。我们建议重新评估n=225 有诊断的抑郁症病史，n=200，再次没有抑郁症病史，从而扩展 该数据库的年龄最高为59岁，涵盖中年人。我们将确定特质情绪修复的潜在轨迹 从18岁到59岁，并确定其相关性以及个性、治疗暴露和 ANS对班级成员的生理功能；将在实验室检查修复情绪的能力；我们 将使用一种新的实验程序(认知努力贴现范式或COG-ED)，该程序 量化认知努力的主观成本(涉及执行任务的成本效益计算)，以 考察情感负荷对基于努力的决策的影响。我们将测试几个明确表述的 关于以下方面的假设：i)抑郁病史和性别对情绪成熟积极效应的影响 与年龄相关的修复，二)个性和治疗暴露对年龄相关的预测/调节价值 情绪修复的变化，III)ANS中潜在类情绪修复轨迹与性别和转移的关系 随着时间的推移而发挥作用；iv)潜在类情绪修复轨迹对情绪修复成功的预测价值 在实验室中；v)一直抑郁和从未抑郁的群体在COG-ED上的相关差异，以及vi) COG-ED成绩与情绪修复轨迹成员和基于实验室的情绪修复的关系 通过重新集中注意力来表现。我们的研究将填补情绪调节和研究文献中的几个空白 老龄化是评估神经经济学决策方法的程度的第一步 制造反映了一种可能解释情绪修复选择的机制。

Project Summary We are requesting an administrative supplement to make up for the loss of subject enrollment into the study during more than six months of state-mandated closure of our lab due to Covid-19 (while project staff continued to receive salaries). We need to finish recruitment of the proposed sample in order to fulfill the aims of the study and have the statistical power to test key hypotheses. The goals of this study remain as originally proposed. We were to build on a unique sample of Ss, heterogeneous with respect to risk of depressive disorder, who (in prior research studies) repeatedly reported during ages 18-35+ on their emotional well-being and how they attenuate sadness/distress (mood repair); their autonomic nervous system (ANS) functioning associated with affect processing was also assessed via peripheral measures. We propose to re-assess n=225 with histories of diagnosed depression and n=200 with no histories of depression once more, and thus extend the data base up to age 59 years, covering middle-age. We will identify latent trajectories of trait mood repair from ages 18 to 59 years and determine its correlates and the effects of personality, treatment exposure and ANS physiologic functioning on class membership; will examine the ability to repair mood in the laboratory; we will use a novel experimental procedure (the Cognitive Effort Discounting Paradigm or COG-ED), which quantifies the subjective cost of cognitive effort (involved in cost-benefit computations to perform a task), to examine the impact of affective load on effort-based decision making. We will test several clearly articulated hypotheses about : i) the effects of depressive illness history and sex on positive maturational effects in mood repair with age, ii) the predictive/moderating values of personality and treatment exposure on age-related mood repair changes, iii) the relations of latent-class mood repair trajectories to sex and shifts in ANS functioning over time; iv) the predictive value of latent-class mood repair trajectories for mood repair success in the laboratory; v) ever-depressed and never-depressed group-related differences on the COG-ED, and vi) the relations of COG-ED performance to mood repair trajectory membership and lab-based mood repair performance via attention refocusing. Our study will fill several gaps in the literature on emotion regulation and aging and represents the first step to assess the extent to which a neuro-economic approach to decision making reflects a mechanism that may explain mood repair choices.