A randomized trial of dance on mood, balance and brain in Alzheimer's Disease

舞蹈对阿尔茨海默病患者情绪、平衡和大脑影响的随机试验

• 批准号: 10364981
• 负责人: CHRISTINA E HUGENSCHMIDT
• 金额: $ 23.83万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10364981
• 关键词: Address; Affect; Alzheimer' s Disease; Alzheimer' s disease care; Anxiety; Atmosphere; Auditory; Biological Markers; Blood; Brain; Brain imaging; Caregiver Burden; Caregivers; Cause of Death; Chronic Disease; Cognition; Cognitive; Communities; Continuity of Patient Care; Cues; Dancing; Data; Dementia; Disease; Educational workshop; Elderly; Environment; Equation; Equilibrium; Exercise; Fostering; Funding; Gait; Goals; Health Services; Home; Intervention; Knowledge; Learning; Link; Measures; Medical Care Costs; Memory; Mental Depression; Methods; Modeling; Moods; Movement; Music; Neurodegenerative Disorders; Palliative Care; Parkinson Disease; Persons; Physical Function; Physiological; Quality of life; Randomized; Research Design; Scientist; Social Conditions; Stress; Structure; Symptoms; Testing; Training; United States National Institutes of Health; World Health Organization; adjudicate; anxiety symptoms; artist; base; behavioral outcome; body system; body-mind; care systems; depressive symptoms; design; evidence base; graph theory; health care service; improved; instructor; neuroimaging; neuromechanism; neuropsychiatric symptom; patient population; persistent symptom; professor; randomized trial; reduce symptoms; relating to nervous system; response; social; social engagement; social group; social movement; symptom management; uptake

Project Summary Alzheimer’s disease (AD) is the most common form of dementia, the most common neurodegenerative disease in older adults, and the 6th leading cause of death in the US. Neuropsychiatric symptoms (apathy, depression, anxiety) and altered gait and balance are prominent secondary symptoms of AD that increase medical costs and decrease quality of life (QoL) for the person with dementia and their caregiver. Care for AD and other dementias in the US was estimated at $203 billion in 2013. Palliative care services are health services that aim to relieve disease symptoms that decrease QoL for people with chronic disease and their caregivers. The World Health Organization has identified a need to integrate evidence-based palliative care services into the continuum of care for serious chronic diseases including AD. However, two recent NIH workshops concluded that lack of evidence limits the broader use of non-pharmacologic activities to relieve secondary symptoms of chronic disease, and identified arts-based mind-body practices as particularly understudied. Dance is an arts- based activity that can improve QoL, decrease symptoms of depression, and improve balance in healthy older adults, those with Parkinson disease, and AD. Thus, dance simultaneously addresses two sets of prominent secondary symptoms in AD: 1) gait and balance and 2) neuropsychiatric symptoms. However, the mechanisms by which dance exerts these effects are unknown. Filling this knowledge gap could increase the use of dance to improve QoL in a large and growing patient population. In addition, a better understanding of the physiological changes that occur during dance that are linked to improved QoL and symptom management could facilitate identification of other interventions that may ameliorate secondary symptoms of AD, and other patient populations that might benefit from dance. We present pilot data to support our hypothesis that dance improves QoL in older adults with AD through changes in brain activity in brain networks related to movement and social engagement. We hypothesize that dance benefits QoL by simultaneously improving balance and gait through movement, and improving apathy and depression through social engagement. We have laid out a rigorous scientific design to test the independent contributions of dance movement and social engagement to QoL. In addition, we propose to collect measures that will allow us to learn about how dance affects different body systems. We will collect brain imaging data to evaluate changes in brain function and structure; detailed measures of balance and gait; and blood biomarkers of stress. Better understanding of how dance affects the body and brain to improve quality of life in people with AD may improve the quality of palliative care services offered to people with AD by helping to understand how to better use non-pharmacologic interventions to target secondary symptoms that affect QoL.

项目摘要 阿尔茨海默氏病（AD）是最常见的痴呆形式，是最常见的神经退行性疾病 在老年人和美国第六大死亡原因。神经精神症状（冷漠，抑郁， 焦虑）和收集和平衡的改变是增加医疗费用的主要次要症状 并降低痴呆症患者及其护理人员的生活质量（QOL）。关心广告和其他 2013年，美国的痴呆症估计为2030亿美元。姑息治疗服务是卫生服务 缓解疾病症状，减少慢性疾病及其护理人员的质量。 世界卫生组织已经确定需要将基于证据的姑息治疗服务整合到 包括AD在内的严重慢性疾病的持续护理。但是，最近的两个NIH研讨会得出了结论 缺乏证据限制了非药物活动的广泛使用来挽救次要症状 慢性病，并确定了基于艺术的思维体实践。舞蹈是艺术 - 可以改善QOL，减轻抑郁症状并改善健康老年人平衡的基于活动 成人，患有帕金森氏病的人和广告。那就是舞蹈只是解决了两套突出的 AD中的次要症状：1）步态和平衡以及2）神经精神症状。但是，机制 舞蹈发挥这些影响是未知的。填补这一知识差距可能会增加舞蹈的使用 在大型且不断增长的患者人群中改善QOL。另外，更好地理解 舞蹈期间发生的身体变化与改善的QOL和症状管理有关 可以促进鉴定其他可能改善AD的次要症状的干预措施，其他 可能会从舞蹈中受益的患者人群。我们提供了飞行员数据，以支持我们的假设 通过与运动有关 和社会参与。我们假设通过简单地改善平衡和 通过运动步态，通过社会参与改善冷漠和沮丧。我们已经布置了 严格的科学设计，以测试舞蹈运动和社会参与的独立贡献 QOL。此外，我们建议收集措施，使我们能够了解舞蹈如何影响不同的措施 身体系统。我们将收集大脑成像数据以评估大脑功能和结构的变化；详细的 平衡与战斗的衡量；和压力的血液生物标志物。更好地了解舞蹈如何影响 身体和大脑以改善广告患者的生活质量可能会提高姑息治疗服务的质量 通过帮助了解如何更好地使用非药物干预措施来针对目标，向患有广告的人提供 影响QOL的次要症状。

项目成果

Improvisational Movement to Improve Quality of Life in Older Adults With Early-Stage Dementia: A Pilot Study.

• DOI: 10.3389/fspor.2021.796101
• 发表时间: 2021
• 期刊: Frontiers in sports and active living
• 影响因子: 2.7
• 作者: Thumuluri D;Lyday R;Babcock P;Ip EH;Kraft RA;Laurienti PJ;Barnstaple R;Soriano CT;Hugenschmidt CE
• 通讯作者: Hugenschmidt CE