Establishing the optimal frequency of dance movement for neurocognitive and physical outcomes in people at risk of Alzheimer's disease

确定舞蹈动作的最佳频率，以改善阿尔茨海默病风险人群的神经认知和身体状况

• 批准号: 10610458
• 负责人: CHRISTINA E HUGENSCHMIDT
• 金额: $ 76.33万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610458
• 关键词: Adherence; Adult; Aerobic; Aerobic Exercise; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Behavior; Behavioral; Brain; Brain-Derived Neurotrophic Factor; Caring; Cognition; Cognitive; Communities; Dance Therapy; Dancing; Data; Dementia; Drops; Educational process of instructing; Elderly; Epidemiology; Equilibrium; Exercise; Frequencies; Funding; Health; Heart Rate; Image; Impaired cognition; Individual; Intervention; Knowledge; Leisures; Magnetic Resonance Imaging; Measures; Mediator; Methods; Modeling; Movement; Music; Neurocognitive; Outcome; Outcome Assessment; Outcome Measure; Persons; Physical Function; Physical activity; Populations at Risk; Psychologist; Questionnaires; Randomized, Controlled Trials; Recording of previous events; Research; Research Personnel; Risk; Running; Sample Size; Self Efficacy; Serum; Social Interaction; Specificity; Structure; Symptoms; Testing; Time; United States National Institutes of Health; Walking; Work; acceptability and feasibility; artist; behavior change; brain health; brain volume; cardiorespiratory fitness; cognitive benefits; cognitive enhancement; comparison control; exercise intervention; exercise physiologist; experience; fall risk; fitness; forest; human old age (65+); improved; intrinsic motivation; lifestyle intervention; motor learning; neuroimaging; phase III trial; primary outcome; programs; psychosocial; recruit; response; satisfaction; secondary outcome; social; social engagement; theories; treadmill; trial design; white matter

PROJECT SUMMARY Dance movement is a form of physical activity that may benefit the brain as much or more than structured aerobic exercise. Despite the potential of dance as an intervention to promote neurocognitive health, gaps in knowledge about essential intervention components are a barrier to definitive trials, specifically:1) a lack of specificity on key prescription parameters including how many times a week dance classes should be taught, 2) need for better estimates of how large an effect dance has on fitness and the brain, and 3) little understanding of the expected time course for change in fitness and the brain in response to dance. The primary aim of this proposal is to test whether weekly dance frequency differentially modifies key outcomes, and from this to test effect sizes to determine sufficient sample sizes for a larger-scale trial. Physical activity promoting interventions tested in older adults have traditionally focused on exercise, i.e., structured physical activity of at least moderate intensity with the express purpose of improving health or fitness. However, in 2003, epidemiological evidence showed that social dance was the only leisure time physical activity associated with lower Alzheimer’s disease risk. Since then, multiple smaller studies have shown benefits of dance movement and dance therapy on mobility and neurocognitive health in older adults, including cardiorespiratory fitness, balance, white matter health, and cognition. Dance movement inherently involves simultaneous cognitive stimulation through motor learning and dual-tasking; social interactions; aerobic physical activity that elevates heart rate and improves cardiorespiratory fitness; and improves balance and reduces fall risk. Dance also satisfies key antecedents of lasting behavior change outlined in contemporary behavioral theories including self-efficacy, intrinsic motivation, autonomy, and relatedness. Dance is also culturally relevant and has been practiced spontaneously for thousands of years. This means dance may result in better long-term adherence than more commonly studied forms of aerobic exercise like brisk walking, where data from our group and others shows that adherence drops significantly after intervention ends. This proposal plans to assess outcomes of 1x/weekly, 2x/weekly, and 3x/weekly dance movement classes and 1x/week music appreciation class control at 4 time-points over 6 months to determine the time course of changes in cardiorespiratory fitness, cognition, and key secondary outcomes in 160 adults ≥ 65 years old at risk for Alzheimer’s disease due to subjective cognitive decline. 1x/weekly is common for community classes and has been tested in multiple dance studies; 2x/weekly is most common in dance research; and 3x/weekly is most common for aerobic exercise interventions like treadmill walking that target CRF. We aim to determine the optimal frequency of dance movement intervention for a Phase III trial that will effect change in relevant outcomes while maintaining attendance.

项目摘要 舞蹈运动是一种体育锻炼的一种形式，可能使大脑受益于结构化 有氧运动。尽管舞蹈作为促进神经认知健康的干预潜力，但差距 有关基本干预组件的知识是确定试验的障碍，特别是：1）缺乏 关键处方参数的特异性，包括每周应教多少次舞蹈课， 2）需要更好地估算舞蹈对健身和大脑的影响的大小，3）很少 理解健身变化和大脑的预期时间课程，以应对舞蹈。这 该建议的主要目的是测试每周舞蹈频率是否会改变关键结果的改变， 并从中测试效应量，以确定大规模试验的足够样本量。体育锻炼 促进在老年人中测试的干预措施传统上专注于运动，即结构化的物理 至少中等强度的活动，以改善健康或健身的明确目的。但是，在 2003年，流行病学证据表明，社会舞蹈是唯一相关的休闲时间体育锻炼 患阿尔茨海默氏病的风险。从那以后，多个较小的研究表明了舞蹈的好处 老年人的运动和神经认知健康的运动和舞蹈疗法，包括心肺 健身，平衡，白质健康和认知。舞蹈运动本质上涉及同时 通过运动学习和双重任务来认知刺激；社会互动；有氧运动 提高心率并改善心肺健康；并改善平衡并降低跌倒风险。舞蹈 还满足当代行为理论中概述的持久行为变化的关键先例 包括自我效能感，内在动机，自主性和相关性。舞蹈也与文化相关， 已经进行了数千年的赞助。这意味着舞蹈可能会带来更好的长期 依从性比更常见的有氧运动形式（如轻快步行），我们的数据来自我们 小组和其他人表明，干预结束后依从性大大下降。该建议计划 评估1倍/每周的成果，每周2倍，每周3倍/每周舞蹈运动和1倍/周音乐 在6个月内4个时间点的欣赏类控制，以确定变化的时间过程 心肺健康，认知和关键的次要结果≥65岁的成年人有风险 阿尔茨海默氏病由于主观认知能力下降。 1倍/每周在社区课程中很常见，并且 在多个舞蹈研究中进行了测试； 2倍/每周在舞蹈研究中最常见；和3倍/每周最多 有氧运动干预措施（如跑步机行走）的常见。我们旨在确定 III期试验的最佳舞蹈运动干预频率将影响相关的变化 保持出勤率的结果。