Establishing the optimal frequency of dance movement for neurocognitive and physical outcomes in people at risk of Alzheimer's disease

确定舞蹈动作的最佳频率，以改善阿尔茨海默病风险人群的神经认知和身体状况

• 批准号: 10610458
• 负责人: CHRISTINA E HUGENSCHMIDT
• 金额: $ 76.33万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610458
• 关键词: Adherence; Adult; Aerobic; Aerobic Exercise; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Behavior; Behavioral; Brain; Brain-Derived Neurotrophic Factor; Caring; Cognition; Cognitive; Communities; Dance Therapy; Dancing; Data; Dementia; Drops; Educational process of instructing; Elderly; Epidemiology; Equilibrium; Exercise; Frequencies; Funding; Health; Heart Rate; Image; Impaired cognition; Individual; Intervention; Knowledge; Leisures; Magnetic Resonance Imaging; Measures; Mediator; Methods; Modeling; Movement; Music; Neurocognitive; Outcome; Outcome Assessment; Outcome Measure; Persons; Physical Function; Physical activity; Populations at Risk; Psychologist; Questionnaires; Randomized, Controlled Trials; Recording of previous events; Research; Research Personnel; Risk; Running; Sample Size; Self Efficacy; Serum; Social Interaction; Specificity; Structure; Symptoms; Testing; Time; United States National Institutes of Health; Walking; Work; acceptability and feasibility; artist; behavior change; brain health; brain volume; cardiorespiratory fitness; cognitive benefits; cognitive enhancement; comparison control; exercise intervention; exercise physiologist; experience; fall risk; fitness; forest; human old age (65+); improved; intrinsic motivation; lifestyle intervention; motor learning; neuroimaging; phase III trial; primary outcome; programs; psychosocial; recruit; response; satisfaction; secondary outcome; social; social engagement; theories; treadmill; trial design; white matter

PROJECT SUMMARY Dance movement is a form of physical activity that may benefit the brain as much or more than structured aerobic exercise. Despite the potential of dance as an intervention to promote neurocognitive health, gaps in knowledge about essential intervention components are a barrier to definitive trials, specifically:1) a lack of specificity on key prescription parameters including how many times a week dance classes should be taught, 2) need for better estimates of how large an effect dance has on fitness and the brain, and 3) little understanding of the expected time course for change in fitness and the brain in response to dance. The primary aim of this proposal is to test whether weekly dance frequency differentially modifies key outcomes, and from this to test effect sizes to determine sufficient sample sizes for a larger-scale trial. Physical activity promoting interventions tested in older adults have traditionally focused on exercise, i.e., structured physical activity of at least moderate intensity with the express purpose of improving health or fitness. However, in 2003, epidemiological evidence showed that social dance was the only leisure time physical activity associated with lower Alzheimer’s disease risk. Since then, multiple smaller studies have shown benefits of dance movement and dance therapy on mobility and neurocognitive health in older adults, including cardiorespiratory fitness, balance, white matter health, and cognition. Dance movement inherently involves simultaneous cognitive stimulation through motor learning and dual-tasking; social interactions; aerobic physical activity that elevates heart rate and improves cardiorespiratory fitness; and improves balance and reduces fall risk. Dance also satisfies key antecedents of lasting behavior change outlined in contemporary behavioral theories including self-efficacy, intrinsic motivation, autonomy, and relatedness. Dance is also culturally relevant and has been practiced spontaneously for thousands of years. This means dance may result in better long-term adherence than more commonly studied forms of aerobic exercise like brisk walking, where data from our group and others shows that adherence drops significantly after intervention ends. This proposal plans to assess outcomes of 1x/weekly, 2x/weekly, and 3x/weekly dance movement classes and 1x/week music appreciation class control at 4 time-points over 6 months to determine the time course of changes in cardiorespiratory fitness, cognition, and key secondary outcomes in 160 adults ≥ 65 years old at risk for Alzheimer’s disease due to subjective cognitive decline. 1x/weekly is common for community classes and has been tested in multiple dance studies; 2x/weekly is most common in dance research; and 3x/weekly is most common for aerobic exercise interventions like treadmill walking that target CRF. We aim to determine the optimal frequency of dance movement intervention for a Phase III trial that will effect change in relevant outcomes while maintaining attendance.

项目总结 舞蹈运动是一种身体活动形式，它对大脑的益处与结构化运动一样多或更多 有氧运动。尽管舞蹈作为一种干预手段有可能促进神经认知健康，但在 有关基本干预组件的知识是最终试验的障碍，具体而言：1)缺乏 具体说明关键的处方参数，包括每周应该教授多少次舞蹈课， 2)需要更好地估计舞蹈对健康和大脑的影响有多大，而3)很少 了解健身和大脑对舞蹈做出反应的预期时间进程。这个 这项提议的主要目的是测试每周的舞蹈频率是否会不同地改变关键的结果， 并由此测试效应大小，以确定足够的样本大小，以进行更大规模的试验。体力活动 在老年人中测试的促进干预措施传统上侧重于锻炼，即有组织的身体锻炼 至少是中等强度的运动，明确的目的是增进健康或健身。但是，在 2003年，流行病学证据表明，交际舞是唯一与之相关的休闲体育活动 阿尔茨海默氏症风险较低。从那时起，多项规模较小的研究显示了跳舞的好处 运动和舞蹈疗法对老年人活动能力和神经认知健康的影响，包括心肺功能 健身、平衡、白质健康和认知。舞蹈动作本身就涉及到同步 通过运动学习和双重任务的认知刺激；社会互动；有氧体育活动 加快心率，改善心肺健康；改善平衡，降低摔倒风险。跳舞 也满足了当代行为理论中概述的持久行为改变的关键前提 包括自我效能感、内在动机、自主性和关联性。舞蹈也具有文化相关性， 已经自发地练习了几千年。这意味着跳舞可能会带来更好的长期效果。 坚持比更普遍研究的有氧运动形式，如快步走，在那里我们的数据 小组和其他人的研究表明，干预结束后，依从性显著下降。这项提案计划 评估每周1次、2次/周和3次/周的舞蹈动作课和1次/周的音乐的结果 鉴赏课控制在4个时间点超过6个月，以确定时间进程中的变化 16 0名65岁≥高危人群的心肺功能、认知和关键的二次结局 阿尔茨海默病是由于主观认知能力下降所致。每周1次在社区课程中很常见，并有 在多个舞蹈研究中进行了测试；每周2次在舞蹈研究中最常见；每周3次是最常见的 常见于有氧运动干预，如以CRF为目标的跑步机行走。我们的目标是确定 影响相关因素变化的III期试验的最佳舞蹈动作干预频率 结果，同时保持出席率。