Establishing the optimal frequency of dance movement for neurocognitive and physical outcomes in people at risk of Alzheimer's disease

确定舞蹈动作的最佳频率，以改善阿尔茨海默病风险人群的神经认知和身体状况

• 批准号: 10610458
• 负责人: CHRISTINA E HUGENSCHMIDT
• 金额: $ 76.33万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610458
• 关键词: Adherence; Adult; Aerobic; Aerobic Exercise; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Behavior; Behavioral; Brain; Brain-Derived Neurotrophic Factor; Caring; Cognition; Cognitive; Communities; Dance Therapy; Dancing; Data; Dementia; Drops; Educational process of instructing; Elderly; Epidemiology; Equilibrium; Exercise; Frequencies; Funding; Health; Heart Rate; Image; Impaired cognition; Individual; Intervention; Knowledge; Leisures; Magnetic Resonance Imaging; Measures; Mediator; Methods; Modeling; Movement; Music; Neurocognitive; Outcome; Outcome Assessment; Outcome Measure; Persons; Physical Function; Physical activity; Populations at Risk; Psychologist; Questionnaires; Randomized, Controlled Trials; Recording of previous events; Research; Research Personnel; Risk; Running; Sample Size; Self Efficacy; Serum; Social Interaction; Specificity; Structure; Symptoms; Testing; Time; United States National Institutes of Health; Walking; Work; acceptability and feasibility; artist; behavior change; brain health; brain volume; cardiorespiratory fitness; cognitive benefits; cognitive enhancement; comparison control; exercise intervention; exercise physiologist; experience; fall risk; fitness; forest; human old age (65+); improved; intrinsic motivation; lifestyle intervention; motor learning; neuroimaging; phase III trial; primary outcome; programs; psychosocial; recruit; response; satisfaction; secondary outcome; social; social engagement; theories; treadmill; trial design; white matter

PROJECT SUMMARY Dance movement is a form of physical activity that may benefit the brain as much or more than structured aerobic exercise. Despite the potential of dance as an intervention to promote neurocognitive health, gaps in knowledge about essential intervention components are a barrier to definitive trials, specifically:1) a lack of specificity on key prescription parameters including how many times a week dance classes should be taught, 2) need for better estimates of how large an effect dance has on fitness and the brain, and 3) little understanding of the expected time course for change in fitness and the brain in response to dance. The primary aim of this proposal is to test whether weekly dance frequency differentially modifies key outcomes, and from this to test effect sizes to determine sufficient sample sizes for a larger-scale trial. Physical activity promoting interventions tested in older adults have traditionally focused on exercise, i.e., structured physical activity of at least moderate intensity with the express purpose of improving health or fitness. However, in 2003, epidemiological evidence showed that social dance was the only leisure time physical activity associated with lower Alzheimer’s disease risk. Since then, multiple smaller studies have shown benefits of dance movement and dance therapy on mobility and neurocognitive health in older adults, including cardiorespiratory fitness, balance, white matter health, and cognition. Dance movement inherently involves simultaneous cognitive stimulation through motor learning and dual-tasking; social interactions; aerobic physical activity that elevates heart rate and improves cardiorespiratory fitness; and improves balance and reduces fall risk. Dance also satisfies key antecedents of lasting behavior change outlined in contemporary behavioral theories including self-efficacy, intrinsic motivation, autonomy, and relatedness. Dance is also culturally relevant and has been practiced spontaneously for thousands of years. This means dance may result in better long-term adherence than more commonly studied forms of aerobic exercise like brisk walking, where data from our group and others shows that adherence drops significantly after intervention ends. This proposal plans to assess outcomes of 1x/weekly, 2x/weekly, and 3x/weekly dance movement classes and 1x/week music appreciation class control at 4 time-points over 6 months to determine the time course of changes in cardiorespiratory fitness, cognition, and key secondary outcomes in 160 adults ≥ 65 years old at risk for Alzheimer’s disease due to subjective cognitive decline. 1x/weekly is common for community classes and has been tested in multiple dance studies; 2x/weekly is most common in dance research; and 3x/weekly is most common for aerobic exercise interventions like treadmill walking that target CRF. We aim to determine the optimal frequency of dance movement intervention for a Phase III trial that will effect change in relevant outcomes while maintaining attendance.

项目摘要 舞蹈运动是一种身体活动形式，它可能使大脑受益不亚于或超过结构化 有氧运动尽管舞蹈作为促进神经认知健康的干预措施具有潜力，但 关于基本干预成分的知识是确定性试验的障碍，具体而言：1）缺乏 关键处方参数的具体性，包括每周应该教多少次舞蹈课， 2)需要更好地估计舞蹈对健康和大脑的影响有多大，3）很少 了解健身和大脑对舞蹈反应的预期时间过程。的 该提议的主要目的是测试每周跳舞频率是否差异地改变关键结果， 并由此来检验效应量，以确定足够的样本量进行更大规模的试验。身体活动 在老年人中测试的促进干预措施传统上侧重于锻炼，即，结构化物理 至少中等强度的活动，以改善健康或健身为明确目的。但在 2003年，流行病学证据表明，交谊舞是唯一的休闲时间的身体活动有关， 患老年痴呆症的风险更低。从那时起，多个较小的研究表明舞蹈的好处 运动和舞蹈疗法对老年人的活动能力和神经认知健康的影响，包括心肺功能 健康、平衡、白色物质健康和认知。舞蹈动作本质上涉及同时 通过运动学习和双重任务的认知刺激;社会互动;有氧体育活动， 提高心率，改善心肺功能;改善平衡，降低跌倒风险。舞蹈 也符合当代行为理论中所概述的持久行为改变的关键前提 包括自我效能、内在动机、自主性和关联性。舞蹈也与文化相关， 几千年来都是自发的这意味着舞蹈可能会带来更好的长期效果。 坚持比更常见的研究形式的有氧运动，如快走，其中数据来自我们的 小组和其他人的研究表明，干预结束后，依从性显著下降。该提案计划 评估每周1次、每周2次和每周3次舞蹈运动课程和每周1次音乐的效果 在6个月内的4个时间点进行评价类控制，以确定 160例≥ 65岁有心脏病风险的成人的心肺功能、认知和关键次要结局 阿尔茨海默病是由于主观认知能力下降。每周1次是社区课程的常见课程， 在多个舞蹈研究中进行了测试;每周2次是舞蹈研究中最常见的;每周3次是最常见的 常见于针对CRF的有氧运动干预，如跑步机行走。我们的目标是确定 第三阶段试验的最佳舞蹈运动干预频率，将影响相关的变化 结果，同时保持出席。