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The Brain-Behavior Relationship: Age, Hearing, and Their Effects on Understanding Speech in Noise

大脑与行为的关系：年龄、听力及其对理解噪声中言语的影响

基本信息

批准号：
10760616
负责人：
Curtis J Billings
金额：
$ 25.12万
依托单位：
IDAHO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10760616
关键词：
Brain Behavior Relationship Age Hearing

项目摘要

Project Summary Approximately 37.5 million Americans have some problem hearing, and one of the chief complaints of those with hearing impairment is difficulty communicating in background noise. In addition, many older individuals have difficulties understanding speech in background noise beyond what would be expected based solely on their audiometric thresholds. There is a fundamental need for improved diagnosis and treatment of speech understanding in noise difficulties. This research program sets out to establish electrophysiological correlates of speech-in-noise understanding with the goal of supplementing speech-in-noise testing. The assumption is that accurate perception in noise is dependent, in part, on the accuracy of neural coding of the auditory stimulus. By combining electrophysiological and behavioral information we can advance our understanding of perception-in-noise difficulties and predict outcomes in difficult-to-test individuals using physiological testing. The clinical significance of the research proposed is related directly to the ability to predict, more accurately diagnose, and more precisely treat perception-in-noise difficulties. An electrophysiological measure that predicts speech perception will allow for improved assessment of difficult-to-test populations and provide information about the capacity of that auditory system to encode certain stimuli. This will allow the clinician to tailor treatment strategies to the specific needs of the individual and to counsel patients more effectively in terms of the expectations they should have and the benefit they should expect as a result of specific treatments. Therefore, to further our understanding of signal-in-noise perception and neural coding, we will use brainstem, cortical, and cognitive auditory evoked potentials and behavioral speech understanding-in-noise measures with age and hearing impairment as continuous variables to characterize the effect sizes of various covariates and to improve our understanding of the relationship between brain and behavioral measures.

项目概要大约 3750 万美国人有听力问题，其中一位主要听力障碍人士的抱怨是在背景噪音中交流困难。在此外，许多老年人在背景噪音中理解语音有困难超出了仅基于听力阈值的预期。有一个改进噪声中语音理解的诊断和治疗的根本需求困难。该研究计划旨在建立电生理学相关性噪声中的语音理解，旨在补充噪声中的语音测试。这假设是，噪声中的准确感知部分取决于神经网络的准确性听觉刺激的编码。通过结合电生理和行为信息我们可以增进对噪声感知困难的理解并预测结果使用生理测试难以测试个体。所提出的研究的临床意义与以下能力直接相关：预测、更准确地诊断并更精确地治疗噪声中的感知困难。一个预测言语感知的电生理测量将有助于改善评估难以测试的人群并提供有关其能力的信息听觉系统对某些刺激进行编码。这将使临床医生能够制定治疗方案针对个人特定需求的策略，并更有效地为患者提供建议他们应该有的期望以及他们应该期望的好处具体治疗方法。因此，为了进一步了解噪声中的信号感知和神经编码，我们将使用脑干、皮质和认知听觉诱发电位噪声中的行为言语理解测量与年龄和听力障碍连续变量来表征各种协变量的效应大小并改进我们的了解大脑和行为测量之间的关系。