Core 2: Clinical Resource Core

核心 2：临床资源核心

• 批准号: 10359189
• 负责人: Kathleen Lombard Poston
• 金额: $ 29.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10359189
• 关键词: Abbreviations; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Autopsy; Award; Brain; Cerebrospinal Fluid; Cerebrovascular Trauma; Clinical; Clinical Research; Consensus; Data; Dementia; Dementia with Lewy Bodies; Diagnostic; Diagnostic tests; Disasters; Enrollment; Evaluation; Health; Individual; Lewy Body Disease; Lipoproteins; Neuropsychological Tests; Neuropsychology; Parkinson Disease; Parkinson' s Dementia; Participant; Proteins; Public Health; RARG gene; Research; Research Infrastructure; Research Institute; Resource Allocation; Resources; Review Committee; Sampling; Source; Spinal Puncture; Test Result; Therapeutic; Time; Ventricular; Work; clinical diagnosis; clinical diagnostics; extracellular vesicles; nervous system disorder; neuroimaging; next generation; programs; translational proteomics

Abstract Alzheimer's disease (AD) is a major threat to health of older individuals and is a looming public health disaster. Needed solutions in diagnostics and therapeutics will come only through research. Our contribution to this overall project is to provide clinical resources to support the Projects. This includes consensus clinical diagnosis, systematic neuropsychological test results, neuroimaging data, CSF obtained by research quality lumbar puncture, and brain autopsy. Our Core will leverage existing clinical research infrastructure provided by the Stanford AD Center and the Stanford Udall Center. Additional samples also will be provided by our long-time collaborators, Dr. Doug Galasko from the UCSD AD Center, and Dr. Thomas Beach from Banner Research Institute. The Clinical Resource Core's Specific Aims are: 1) Consensus Clinical Diagnosis and Neuropsychological Test Results, 2) CSF Samples and 3) Brain Autopsy .

抽象的 阿尔茨海默病（AD）是老年人健康的主要威胁，也是一场迫在眉睫的公共卫生灾难。 诊断和治疗所需的解决方案只能通过研究来实现。我们对此的贡献 总体项目是提供临床资源来支持该项目。这包括临床共识 诊断、系统神经心理学测试结果、神经影像数据、研究质量获得的脑脊液 腰椎穿刺和脑部尸检。 我们的核心将利用斯坦福 AD 中心和 斯坦福尤德尔中心。我们的长期合作者 Doug 博士也将提供更多样品 来自 UCSD AD 中心的 Galasko 和来自 Banner 研究所的 Thomas Beach 博士。临床 资源核心的具体目标是：1) 达成共识的临床诊断和神经心理学测试结果，2) 脑脊液样本和 3) 脑尸检 。